Rice Bran Oil Attenuates Chronic Inflammation by Inducing M2 Macrophage Switching in High-Fat Diet-Fed Obese Mice

Park, Hye Jeong; Yu, Seungmin; Kim, Wooki

doi:10.3390/foods10020359

Cited by 10 publications

(8 citation statements)

References 44 publications

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“…RO and BO also contain high levels of micronutrients, such as γ‐oryzanol, phytosterols and squalene. γ‐Oryzanol may have anti‐inflammatory effects by causing appropriate macrophage polarization and reducing the secretion of pro‐inflammatory factors by macrophages 53,54 . Phytosterols and squalene inhibit the production of inflammatory enzymes and pro‐inflammatory cytokines by reducing nuclear factor‐kappa B expression 55,56 .…”

Section: Discussionmentioning

confidence: 99%

“…γ-Oryzanol may have anti-inflammatory effects by causing appropriate macrophage polarization and reducing the secretion of pro-inflammatory factors by macrophages. 53,54 Phytosterols and squalene inhibit the production of inflammatory enzymes and pro-inflammatory cytokines by reducing nuclear factor-kappa B expression. 55,56 Furthermore, in the www.soci.org L Yang et al…”

Section: Discussionmentioning

confidence: 99%

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Beneficial effects of monounsaturated fatty acid‐rich blended oils with an appropriate polyunsaturated/saturated fatty acid ratio and a low n‐6/n‐3 fatty acid ratio on the health of rats

Yang

Chu

et al. 2022

J Sci Food Agric

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BACKGROUND The effects of dietary fat on health are influenced by its fatty acid profile. We aimed to determine the effects of monounsaturated fatty acid (MUFA)‐rich blended oils (BO) containing a balance of polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFAs) and with a low n‐6/n‐3 PUFA ratio on the health of rats fed normal or high‐fat diets. The BO was obtained by mixing red palm oil, rice bran oil (RO), tea seed oil and flaxseed oil in appropriate proportions. RESULTS BO consumption reduced the serum low‐density lipoprotein cholesterol (LDL‐C), non‐esterified fatty acid (NEFA), insulin (INS), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), interleukin‐1 (IL‐1), high‐sensitivity C‐reactive protein (hs‐CRP), malondialdehyde (MDA), lipid peroxide (LPO) and oxidized LDL (ox‐LDL) concentrations and the homeostasis model assessment of insulin resistance (HOMA‐IR); it increased the high‐density lipoprotein cholesterol (HDL‐C), glutathione peroxidase (GSH‐Px) and superoxide dismutase (SOD) concentrations, and the bone mineral density (BMD) versus control oil‐containing normal and high‐fat diets. BO also reduced the triglyceride (TG), hs‐CRP, MDA, ox‐LDL and reactive oxygen species (ROS) concentrations; and increased the serum HDL‐C and SOD, and BMD versus RO‐containing high‐fat diets. Finally, BO reduced the glucose (GLU) and INS, and HOMA‐IR; it increased HDL‐C, SOD, femoral weight and BMD versus RO‐containing normal diets. CONCLUSION BOs with an appropriate fatty acid profile have beneficial effects on the glucolipid metabolism, inflammation, oxidative stress and bone quality of rats when included in both normal and high‐fat diets. © 2022 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Beneficial effects of monounsaturated fatty acid‐rich blended oils with an appropriate polyunsaturated/saturated fatty acid ratio and a low n‐6/n‐3 fatty acid ratio on the health of rats

Yang

Chu

et al. 2022

J Sci Food Agric

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“…In contrast, the density of vessels with smooth muscle wall was decreased on GBD, suggesting attenuation of arteriogenesis. This effect can be mediated via changes of inflammatory state on GBD, known to affect arteriogenesis (52)(53)(54)(55).…”

Section: Discussionmentioning

confidence: 99%

Grain-Based Dietary Background Impairs Restoration of Blood Flow and Skeletal Muscle During Hindlimb Ischemia in Comparison With Low-Fat and High-Fat Diets

et al. 2022

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Background: Among vascular pathologies associated with obesity, peripheral artery disease (PAD) occupies the important position. In clinical practice, nutritional interventions are recommended for patients with PAD. In this work, we investigated how the different dietary backgrounds affect the regeneration rate of ischemic hindlimb in mice.Methods: Male C57BL/6J mice were housed on three types of diet: low-fat (LFD), high-fat (HFD), and grain-based diet (GBD) for 13 weeks. Metabolic parameters including FBG level, ITT, and GTT were evaluated. The blood flow was assessed by laser Doppler scanning on 7, 14, and 21 days after hindlimb ischemia. Necrotic area of m.tibialis, macrophage infiltration, and angiogenesis/arteriogenesis were evaluated by histology. Glucose uptake in recovered skeletal muscle was analyzed using [3H]-2-deoxyglucose, and GLUT1 and GLUT4 expression were assessed by Western blotting.Results: In our work, we developed three experimental groups with different metabolic parameters: LFD with normal glucose metabolism, GBD with mild hyperglycemia, and HFD with impaired glucose tolerance. GBD-fed mice had a tendency to increase necrosis of m. tibialis and significantly higher macrophage infiltration than LFD and HFD groups. Moreover, GBD-fed mice had a trend to decreased blood flow recovery and significantly impaired arteriogenesis. Recovered skeletal muscle of GBD-fed mice had lower glucose uptake and decreased level of GLUT4 expression.Conclusion: Thus, we conclude that dietary background and metabolic status determine the rate of post-ischemic regeneration including angiogenesis, skeletal muscle recovery and metabolic activity. The most effective regeneration is supported by LFD, while the lowest rate of regeneration occurs on GBD.

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“…RBO supplementation improved the anti-inflammatory status (increased the IL-10 level and decreased the IL-6 and TNF-α levels) in bone marrow-derived macrophages. The study showed that RBO could improve obesity-induced chronic inflammation by altering the expression of inflammation-associated markers and macrophage polarization [ 100 ].…”

Section: Anti-obesity Properties Of Rice Branmentioning

confidence: 99%

“…The overall host inflammatory system was improved during RB supplementation. In particular, C-RP, TNF-α, COX-2, VCAM-1, IL-6, and IL-1β levels were improved in serum and adipose tissue and improved vascular and microvascular inflammation [ 86 , 87 , 89 , 100 ]. Moreover, RB supplementation improved the expression of IRS-2 (insulin receptor), GLUT-2 (glucose transporter), and glucokinase in the pancreas [ 96 ], glucose–insulin homeostasis [ 97 ], and reduced the pancreatic islet size and pancreatic insulin [ 98 ].…”

Section: Mechanisms Associated With the Anti-obesity Property Of Rice...mentioning

confidence: 99%

Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran

Sivamaruthi

Alagarsamy²,

Thangaleela

et al. 2023

Foods

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Rice is a major cereal crop and a staple food for nearly 50% of people worldwide. Rice bran (RB) is a nutrient-rich by-product of rice processing. RB is rich in carbohydrates, fibers, proteins, lipids, minerals, and several trace elements (phosphorus, calcium, magnesium, potassium, and manganese). The extraction process and storage have influenced RB extracts and RB oil’s quality. The RB composition has also varied on the rice cultivars. The color of RB indicates the richness of the bioactive compounds, especially anthocyanins. γ-oryzanol, tocopherols, tocotrienols, and unsaturated fatty acids are major components of RB oil. It has been established that RB supplementation could improve the host’s health status. Several preclinical and clinical studies have reported that RB has antioxidant, anticancer, anti-inflammatory, anticolitis, and antidiabetic properties. The beneficial biological properties of RB are partially attributed to its ability to alter the host microbiome and help to maintain and restore eubiosis. Non-communicable diseases (NCDs), including heart disease, diabetes, cancer, and lung disease, account for 74% of deaths worldwide. Obesity is a global health problem and is a major reason for the development of NCDs. The medical procedures for managing obesity are expensive and long-term health supplements are required to maintain a healthy weight. Thus, cost-effective natural adjuvant therapeutic strategy is crucial to treat and manage obesity. Several studies have revealed that RB could be a complementary pharmacological candidate to treat obesity. A comprehensive document with basic information and recent scientific results on the anti-obesity activity of RB and RB compounds is obligatory. Thus, the current manuscript was prepared to summarize the composition of RB and the influence of RB on the host microbiome, possible mechanisms, and preclinical and clinical studies on the anti-obesity properties of RB. This study suggested that the consumption of RB oil and dietary RB extracts might assist in managing obesity-associated health consequences. Further, extended clinical studies in several ethnic groups are required to develop dietary RB-based functional and nutritional supplements, which could serve as an adjuvant therapeutic strategy to treat obesity.

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Rice Bran Oil Attenuates Chronic Inflammation by Inducing M2 Macrophage Switching in High-Fat Diet-Fed Obese Mice

Cited by 10 publications

References 44 publications

Beneficial effects of monounsaturated fatty acid‐rich blended oils with an appropriate polyunsaturated/saturated fatty acid ratio and a low n‐6/n‐3 fatty acid ratio on the health of rats

Beneficial effects of monounsaturated fatty acid‐rich blended oils with an appropriate polyunsaturated/saturated fatty acid ratio and a low n‐6/n‐3 fatty acid ratio on the health of rats

Grain-Based Dietary Background Impairs Restoration of Blood Flow and Skeletal Muscle During Hindlimb Ischemia in Comparison With Low-Fat and High-Fat Diets

Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran

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