Antioxidant and anti-inflammatory effects of quercetin in functional and morphological alterations in streptozotocin-induced diabetic rats

Effect of quercetin nanoparticles on the kidney of the streptozotocin-induced diabetes in male rats: A histological study and serum biochemical alterations

“…Diabetic rats treated with QUNPs (10 and 20 mg/kg bw) presented increased concentration of total protein, albumin and globulin to near NC levels (P ≤ 0.05) and these results agree with several studies (Maciel et al, 2013;Arya et al, 2014). The albumin level was significantly decreased in the diabetic group, which might be due to albumin leakage due to glomerular basement damage of membrane combined with an increase in the pressure of trans glomerular filtration or impaired reabsorption of tubular (Maciel et al, 2013). Also, the results should a significant reduction in concentration of serum albumin in diabetic rats, except the group of rats treated with QUE at 50 mg/kg (Naoum, 1999) …”

“…Quercetin directly scavenges free radicals and ROS; therefore, it is an important flavonoid which is known to be a potent antioxidant (Annapurna et al, 2009;Boots et al, 2008;Jeong et al, 2012) . When treated with 50 mg/kg of QUE, the levels reverted close to normal values observed in control group (P < 0.05) (Maciel et al, 2013;Stanley and Menon, 2001) . Also, Elbe et al (2015) reported that in diabetic group, CAT activity was decreased significantly compared with the control group and were significantly increased in treated group compared with the diabetic group.…”

“…Serum urea and creatinine levels are the most important indicators of kidney functions. Lu et al (2007) and Maciel et al (2013) reported that urea and creatinine levels were increased in diabetic rats as compared to the control group. Also, urea level was increased in diabetic rats when administrated with 5, 25 and 50 mg/kg of QUE than healthy groups treated with the same QUE dosages (P < 0.05).…”

Protective Effect of Quercetin on Histomorphometric Changes in Kidney of Retinoid Acid-Treated Rat Fetuses

“…Quercetin could prevent oxidant injury and cell death by several mechanisms, such as scavengening oxygen radicals, protecting against lipid peroxidation and chelating metal ions. Quercetin directly scavenges the superoxide anion and inhibits several superoxide-generating enzymes such as xanthine oxidase (XO) or the neutrophil membrane NADPH oxidase complex (Maciel et al, 2013).…”

Oral administration of indigenous oxalate degrading lactic acid bacteria and quercetin prevents calcium oxalate stone formation in rats fed with oxalate rich diet

“…Quercetin (QE) is a flavonoid naturally abundant in fruits and vegetables, it is a well-known bioactive flavonoid owing to its antioxidative, anti-inflammatory and cardioprotective properties (Bischoff, 2008;Maciel et al, 2013). Park et al (2008) reported that quercetin reduced lipid peroxidation in MDCK kidney epithelial cells induced by oxalate and also showed the inhibitory effect on urinary crystal deposition in rats.…”