Antioxidant and anti-inflammatory polyphenols and peptides of common bean (Phaseolus vulga L.) milk and yogurt in Caco-2 and HT-29 cell models

Production and processing of antioxidant bioactive peptides: A driving force for the functional food market

“…The second methods work based on electron transfer in which an antioxidant is estimated by comparing it with a certain oxidant ( Zou et al., 2016 , Zou et al., 2016 ). These methods include ferric ion reducing antioxidant power (FRAP), trolox equivalent antioxidant capacity (TEAC), hydroxyl (OH) radical scavenging activity, DPPH radical-scavenging capacity (DPPH), superoxide anion radical-scavenging (O 2 ) activity and superoxide dismutase (SOD)-like activity ( Barkia, Al-haj, Hamid, Zakaria and Saari, 2018 ; Chen et al., 2019 , Chen et al., 2019 ; Iskandar et al., 2015 ; Yang et al., 2018 ). Tables 1 and 2 shows some examples of antioxidant activity evaluation methods for selected protein hydrolysates and peptides.…”

“…Various food derived protein sources have been utilized to produce bioactive peptides. For example, plant sources, such as walnut meal proteins ( Feng et al., 2018 ), hazelnut protein ( Liu et al., 2018 ), sesame protein ( Lu et al., 2019 ), perilla seed protein ( Yang et al., 2018 ), soybean ( Chen et al., 2018 ), common bean ( Chen et al., 2019 , Chen et al., 2019 ) and protein from cauliflower by-products ( Montone et al., 2018a ); animal sources, such as goat, sheep and bovine milk proteins ( Moreno-montoro et al., 2018 ; Tagliazucchi et al., 2018 ; Zanutto-elgui et al., 2019 ), egg ( Wang et al., 2018 ; Eckert et al., 2018 ) and ham ( Xing et al., 2018 ); fish and their by-products, such as salmon ( Neves et al., 2017 ), stone fish protein ( Auwal et al., 2017 ), chub marckerel ( Bashir et al., 2017 ), turbot skin ( Fang et al., 2017 ), shrimp shell discards ( Ambigaipalan and Shahidi, 2017 ), tilapia frame and skin ( Huang et al., 2015 ); and microalgae proteins, such as blue-green algae ( Seddek et al., 2019 ), Irish brown seaweed Ascophyllum nodosum ( Kadam et al., 2016 ), Tetradesmus obliquus microalgae ( Montone et al., 2018b ), have been reported as sources of bioactive peptides.…”

Green chicory leaf extract exerts anti-inflammatory effects through suppressing LPS-induced MAPK/NF-κB activation and hepatoprotective activity in vitro

“…Previous ROS suppressive activities by measuring the conversion of H 2 DCF-DA to DCF in cells were investigated in many studies as a cellular antioxidant activity and ROS behaves like a secondary messenger in many inflammatory pathways (Chen, Zhang, et al, 2019;Ghosh et al, 2018;Lander, 1997). CLE suppressed significantly the ROS generation from the concentration of 10 μg/mL and reduced in a dose-dependent manner in H 2 O 2 accumulated RAW 264.7 cells and Hep G2 Cells.…”

Sangiovese cv Pomace Seeds Extract-Fortified Kefir Exerts Anti-Inflammatory Activity in an In Vitro Model of Intestinal Epithelium Using Caco-2 Cells

“…In addition, red wine polyphenols can reinforce and protect the intestinal barrier against inflammatory stimuli by affecting the tight junction protein expression [9]. Noteworthy, not only plant-derived polyphenols are able to support the gastrointestinal barrier, but also polyphenols derived from milk fermentation, which can be found in products such as yogurt and kefir [10,11]. Fermented milk products showed protective effects towards the intestinal barrier.…”