Antioxidant and anti-neoplastic activities of Picrorhiza kurroa extracts

Rajkumar, V.; Guha, Gunjan; Kumar, R. Ashok

doi:10.1016/j.fct.2010.11.009

Cited by 102 publications

(57 citation statements)

References 23 publications

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“…Many of the phenolics have been shown to contain high levels of antioxidant activities [41] . Among the six plants investigated in the present work, M. zapota had considerably greater total phenol content, and methanol was able to extract more phenolic compounds than aqueous, which is also supported by other researchers [42][43][44] . It is important to examine the correlation between the content of total phenols and the antioxidant potential because some authors have reported that there is no correlation between the content of phenolic compound and the radical scavenging capacity [22,45] .…”

Section: Discussionsupporting

confidence: 89%

Assessment of effect of hydroalcoholic and decoction methods on extraction of antioxidants from selected Indian medicinal plants

Kaneria

Kanani

Chanda

2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionsupporting

confidence: 89%

Assessment of effect of hydroalcoholic and decoction methods on extraction of antioxidants from selected Indian medicinal plants

Kaneria

Kanani

Chanda

2012

Asian Pacific Journal of Tropical Biomedicine

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“…free radicals are one of the major causes for the conversion of normal cell to cancerous cells (Rajkumar et al 2011). Herbs protect human body against ROS and reduce oxidative damage to DNA in cancer initiation or promotion.…”

Section: Introductionmentioning

confidence: 99%

The antioxidant and chemical properties of Berberis vulgaris and its cytotoxic effect on human breast carcinoma cells

2015

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In this study we evaluated the biological activity of alcoholic and aqueous extracts from the fruit of Berberis vulgaris. The total antioxidant capacity of Berberis was characterized by FRAP, DPPH, Folin-Ciocalteu while the anthocyanins content was measured by pH differential method. Cell viability and apoptotic property were determined by MTT and DNA fragmentation assays, respectively. Alcoholic extract of Berberis was richer in antioxidants and anthocyanins compared to aqueous extract. Although both extracts significantly inhibited proliferation of breast cancer cells (MCF-7); these changes were not observed in normal human breast epithelial cells (MCF10-A). The alcoholic extract was more effective in inducing apoptosis as detected by DNA fragmentation in treated cancer cells. Our results suggest that Berberis has potent antioxidant properties and cytotoxic effects that can induce apoptosis. Therefore, Berberis can potentially be exploited for the development of therapeutics to fight against human breast cancer.

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“…Continuing investigation on antioxidant activity of P. kurroa extracts revealed that butanol and ethyl acetate extracts were more efficient in scavenging of free radicals as compared to ethanol extract (Kant et al 2013). On the other hand, Rajkumar et al (2011) observed that both methanolic and aqueous extracts of P. kurroa rhizome exhibited antioxidant potential by scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) and inhibiting lipid peroxidation.…”

Section: Picrorhiza Plant Extractsmentioning

confidence: 97%

Biosynthesis and therapeutic implications of iridoid glycosides from Picrorhiza genus: the road ahead

Kumar

Chauhan

Tandon

2016

J. Plant Biochem. Biotechnol.

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Picrorhiza genus is emerging as an important paradigm for herbal drug formulations due to its versatile iridoid glycosides exhibition and robustness in the treatment of diverse infections including hepatic amoebiasis, cancer, malaria, ulcerative colitis and cerebral ischemia reperfusion injury. Owing to the superiority of these bioactivities, iridoid glycosides from Picrorhiza have become a hot research area over the years. A metabolic pathway for the formation of iridoid glycosides has been proposed. However, some enzymes and genes of this route are still unidentified and demand the enumeration of facilitating pathways contributing to the biosynthesis of iridoid glycosides. This review summarizes the current knowledge of all naturally occurring iridoid glycosides from Picrorhiza, their biosynthesis and pharmacological capabilities which could provide the insight into metabolic regulation and the basis for the development of new drugs.

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Antioxidant and anti-neoplastic activities of Picrorhiza kurroa extracts

Cited by 102 publications

References 23 publications

Assessment of effect of hydroalcoholic and decoction methods on extraction of antioxidants from selected Indian medicinal plants

Assessment of effect of hydroalcoholic and decoction methods on extraction of antioxidants from selected Indian medicinal plants

The antioxidant and chemical properties of Berberis vulgaris and its cytotoxic effect on human breast carcinoma cells

Biosynthesis and therapeutic implications of iridoid glycosides from Picrorhiza genus: the road ahead

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