Antioxidant and Anti-Nociceptive Activities of Ulmus davidiana var. japonica

Jung, Hyun-Joo; Kang, Hyun‐Jung; Song, Yun-Seon; Lim, Chang‐Jin; Park, Eun-Hee

doi:10.4062/biomolther.2008.16.1.009

Cited by 5 publications

(9 citation statements)

References 11 publications

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“…Several previous studies have indicated that U. davidiana extracts of various solvents showed a strong antioxidant activity (Guo & Wang 2007;Jung et al 2008;Ahn & Park 2010;Park 2011). …”

Section: Hydroxyl Radical Scavenging Activitymentioning

confidence: 96%

“…Several previous studies have indicated that water and various solvent extracts of U. davidiana exhibited a high antioxidant property (Guo & Wang 2007;Jung et al 2008;Ahn & Park 2010;Park 2011). Also, the change of several aspects such as physicochemical and microbial properties of U. davidiana powder was investigated during storage (Ahn 2014).…”

mentioning

confidence: 97%

“…including Korea and its bark of the stem and roots are used extensively (Jung et al 2008). Dried and grounded inner bark into powder is used in soups or cereal flours as a thickening agent in food manufacturing (Jung et al 2008).…”

mentioning

confidence: 99%

“…Dried and grounded inner bark into powder is used in soups or cereal flours as a thickening agent in food manufacturing (Jung et al 2008). Catechin and related compounds were detected as phytochemicals of U. davidiana stem bark (Jung et al 2008). cancer, infection, and cardiovascular disease (Freeman 1984;Squadrito & Pryor 1998).…”

mentioning

confidence: 99%

“…However, potent antioxidant activities without any side effect were found in plant as medicinal property in recent studies. By using these medicinal components could be established as natural medicines for prevention and treatment of related diseases ( Jung et al 2008;Choudhary & Swarnkar 2011).…”

mentioning

confidence: 99%

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Antioxidant Activities of Powdered and Ultra-fine Powdered Ulmus Davidiana var. Japonica

Park¹,

Ahn²

2016

KJCLS

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“…Several previous studies have indicated that U. davidiana extracts of various solvents showed a strong antioxidant activity (Guo & Wang 2007;Jung et al 2008;Ahn & Park 2010;Park 2011). …”

Section: Hydroxyl Radical Scavenging Activitymentioning

confidence: 96%

mentioning

confidence: 97%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Antioxidant Activities of Powdered and Ultra-fine Powdered Ulmus Davidiana var. Japonica

Park¹,

Ahn²

2016

KJCLS

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Root bark of Ulmus davidiana var. japonica restrains acute alcohol-induced hepatic steatosis onset in mice by inhibiting ROS accumulation

et al. 2017

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Alcohol-induced hepatic steatosis and inflammation are key drivers of alcohol-induced liver injury, mainly caused by oxidative stress. The roots bark of Ulmus davidiana var. japonica is well known for its substantial antioxidative and antitumorigenic potency. In this study, we examined whether this plant can ameliorate alcohol-induced liver injuries characterized by hepatic steatosis and inflammation through its antioxidative activity. C57BL/6J mice were treated with the root bark extract of Ulmus davidiana var. japonica (RUE; 100 mg of extract/kg bodyweight; oral gavage) and alcohol (1 g/kg of bodyweight; oral gavage) for 5 days. Markers of acute alcohol-induced hepatic steatosis were determined and putative molecular mechanisms responsible for the protection of RUE were investigated. RUE noticeably protected against alcohol-induced hepatic steatosis and inflammation. Reactive oxygen species (ROS), over-produced by alcohol, negatively orchestrated various signaling pathways involved in the lipid metabolism and inflammation. These pathways were restored through the ROS scavenging activity of RUE in the liver. In particular, the expression of lipogenic genes (e.g., SREBP-1, ACC, and FAS) and inflammatory cytokines (e.g., IL-1β, and NF-κB p65) significantly decreased with RUE treatment. Conversely, the expression of fatty acid oxidation-related genes (e.g., SIRT1, AMPKα, and PGC1α) were increased in mice treated with RUE. Thus, the results indicate that RUE counteracts and thus attenuates alcoholic hepatic steatosis onset in mice, possibly by suppressing ROS-mediated steatosis and inflammation.

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LC/ESI-MS/MS profiling of Ulmus parvifolia extracts and evaluation of its anti-inflammatory, cytotoxic, and antioxidant activities

Mina

Melek

Adeeb

et al. 2016

Zeitschrift Für Naturforschung C

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In this study, a comparative liquid chromatography/mass spectroscopy (LC/ESI-MS/MS) profiling of different fractions of Ulmus parvifolia leaves and stems was performed. Identification of compounds was based on comparing the mass spectrometric information obtained including m/z values and individual compound fragmentation pattern to tandem mass spectral library search and literature data. Eleven compounds were tentatively identified in the different analyzed fractions. One of the major constituents of this plant was isolated and identified as Icariside E4 [dihydro-dehydro-diconiferyl alcohol-4-O-α-L-rhamnopyranoside] (5). The evaluation of anti-inflammatory activity of the total methanolic extract using nitric oxide inhibition on LPS-stimulated RAW 264.7 cells model strong anti-inflammatory activity with 17.5% inhibition of nitric oxide production versus 10% inhibition for dexamethasone. The cytotoxic activity of the methanolic extract and Icariside E4 was evaluated against four types of human cell lines using MTT assay. Icariside E4 showed cytotoxic effect against Hep-G2, MCF-7, and CACO-2 cell lines compared to a negligible activity for the total extract. The same extract showed a moderate antioxidant activity with SC50=362.5 μg/mL.

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Antioxidant and Anti-Nociceptive Activities of Ulmus davidiana var. japonica

Cited by 5 publications

References 11 publications

Antioxidant Activities of Powdered and Ultra-fine Powdered Ulmus Davidiana var. Japonica

Antioxidant Activities of Powdered and Ultra-fine Powdered Ulmus Davidiana var. Japonica

Root bark of Ulmus davidiana var. japonica restrains acute alcohol-induced hepatic steatosis onset in mice by inhibiting ROS accumulation

LC/ESI-MS/MS profiling of Ulmus parvifolia extracts and evaluation of its anti-inflammatory, cytotoxic, and antioxidant activities

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