Antioxidant and Antibacterial Activities of Dodecyl Tannin Derivative Linked with 1,2,3‐Triazole

Yuan, Hua; Zhou, Peng; Peng, Zhiyuan; Wang, Chengzhang

doi:10.1002/cbdv.202100558

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…This may explain the stronger antihyperglycemic effects of crude 80% methanol extracts. 56 The ethyl acetate fraction at 200 mg/kg and 400 mg/kg (p<0.01) and glibenclamide at 5 mg/kg (p<0.001) notably reduced blood glucose levels at the first and second hours; compared to the aqueous residue at 100 mg/kg. At the third hour, blood glucose levels were significantly lowered by glibenclamide at 5 mg/kg, ethyl acetate fractions at 200 mg/kg and 400 mg/kg, and aqueous fractions at 200 mg/kg and 400 mg/kg compared to an aqueous residue at 100 mg/kg (p<0.05).…”

Section: Dovepressmentioning

confidence: 93%

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Dereje,

Nardos,

Abdela

et al. 2023

JEP

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Background Because of the scarcity, high cost, and severe side effects of current medications, it is necessary to discover novel, safe, and affordable anti-diabetic drugs. The current study was conducted to evaluate the antidiabetic activities of Verbascum sinaiticum Benth leaves in mice. Methods Leaf coarse powder was extracted with 80% methanol and then fractionated with n-hexane, ethyl acetate, and distilled water. The glucose-lowering effects of V. sinaiticum at 100, 200, and 400mg/kg were then studied. Glibenclamide was used as a positive control at a dose of 5 mg/kg. For oral glucose tolerance tests and hypoglycemia tests, Tween 2% was used as a negative control, while citrate buffer was used as a negative control for antihyperglycemic investigations. The results from the study were evaluated using one-way ANOVA, and then Tukey’s post hoc multiple comparison test was performed. Results Blood glucose levels were significantly reduced by the V. sinaiticum 80% methanol extract at 400 mg/kg (p<0.05). The blood glucose levels were significantly lowered by the aqueous residue at 400 mg/kg (p<0.05) and the ethyl acetate fractions at 200 mg/kg (p<0.01) and 400 mg/kg (p<0.001); however, none of the fraction extracts resulted in hypoglycemic shock in healthy mice. Higher glucose tolerance was seen in orally glucose-loaded mice after exposure to 80% methanol extracts at 200 and 400 mg/kg (p<0.05), the aqueous residual fraction at 200 mg/kg (p<0.01), and the ethyl acetate fraction at 200 and 400 mg/kg (p<0.05). The ethyl acetate fraction at 200 and 400 mg/kg (p<0.01), the 80% methanol extract at 400 mg/kg (p<0.05) and the aqueous residue at 400 mg/kg (p 0.01) significantly lowered blood glucose levels in streptozotocin-induced diabetic mice. Conclusion The results of this study revealed that the 80% methanol extract and solvent fractions of V. sinaiticum Benth leaves are endowed with antidiabetic activity.

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Section: Dovepressmentioning

confidence: 93%

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Dereje,

Nardos,

Abdela

et al. 2023

JEP

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“…In addition to phenolic and flavonoid, tannins are widespread and important bioactive molecules in plant. Tannins have a potent antioxidant and antibacterial activities [32,33]. The data represented the means ± ESM for three replicates.…”

Section: Total Phenolic Flavonoid and Tannins Contentsmentioning

confidence: 99%

Phytochemical Characterization, Antioxidant and Anti-Inflammatory Effects of Cleome arabica L. Fruits Extract against Formalin Induced Chronic Inflammation in Female Wistar Rat: Biochemical, Histological, and In Silico Studies

et al. 2022

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In recent decades, the use of herbs and plants has been of great interest, as they have been the sources of natural products, commonly named as bioactive compounds. In specific, the natural compounds from the Capparaceae family which has been proved to have antioxidant, anti-inflammatory, antimicrobial and anti-carcinogenic activities, by several studies. Cleome arabica L. (CA) specie is the most used medicinal plants in Tunisia and elsewhere in North African countries for treatment of various diseases including diabetes, rheumatism, inflammation, cancer, and digestive disorders. The current work was undertaken to estimate the total phenolic, flavonoid and condensed tannin contents, to identify and quantify the polyphenolic compounds, and to evaluate the antioxidant and the anti-inflammatory proprieties of CA fruits extract against formalin induced chronic inflammation in Female Wistar rats. In fact, the antioxidant activity was tested by Diphenyl-1-Picrylhydrazyl free radical scavenging (DPPH), Ferric reducing antioxidant power (FRAP) and Nitric Oxide radical (NO·). Anti-inflammatory effect of fruits extract was examined using formalin (2%) induced paw edema in rats. Molecular docking tools were used to investigate the interaction of some compounds from CA fruits extract with the cyclooxygenase-2 (COX-2) target protein. Our results showed that, the total phenolic, flavonoid and tannins contents, which were assessed by the Folin-Ciocalteu, Quercetin, and Catechin methods, respectively, were 230.22 mg gallic acid equivalent/g dry weight (mg GAE/g DW), 55.08 mg quercetin equivalent/g dry weight (QE/g DW) and 15.17 mg catechin equivalents/g dry weight (CatE/g DW), respectively. HPLC analysis revealed the presence of five polyphenolic compounds whose catechin was found to be the most abundant compounds. The antioxidant activity of extract was quantified by DPPH, FRAP and NO· tests and IC50 reached the values of 3.346 mg/mL, 2.306 and 0.023 mg/mL, respectively. Cleome fruits ameliorated the histological integrity of the skin and alleviated the disruptions in hematological parameters (WBC, LYM, RBC, and HGB), inflammatory cytokines (IL-1β, IL-6, TNF-α), C-reactive protein, and some oxidative stress markers (TBARS (−49%) and AOPP (−42%) levels, SOD (+33%) and GPx (+75%) activities, and GSH (+49%) content) induced by formalin injection. Moreover, the in-silico investigation had shown that CA fruits extract compounds have a stronger interaction with COX-2 active site, more than the reference drug “indomethacin” (two H-bonds). Our research gives pharmacological backing to the healthcare utilization of Cleome plant in the treatment of inflammatory diseases and oxidative harm.

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“…There are phenol hydroxyl groups in the tannin's structure, [13,14] which could be used as a reducing and stabilizing agent for the synthesis of silver nanoparticles. [13,[15][16][17] Zhang et al [18] prepared cellulose hydrogel-based nano-silver nanocomposite by adding AgNO 3 solution dropwise into the mixture of cellulose and tannic acid(TA), where TA can generate abundant anchor sites for AgCl and the aromatic rings of TA can prevent AgCl nanoparticles from aggregating.…”

Section: Introductionmentioning

confidence: 99%

“…There are phenol hydroxyl groups in the tannin's structure, [13,14] which could be used as a reducing and stabilizing agent for the synthesis of silver nanoparticles [13,15–17] . Zhang et al [18] .…”

Section: Introductionmentioning

confidence: 99%

Preparation of Silver Nanoparticles Supported on Cellulose‐Immobilized Tannin Resin and Its Catalytic Activity

Huang

Zeng

et al. 2022

ChemistrySelect

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Silver nanoparticles (AgNPs) was loaded on spherical celluloseimmobilized tannin resin (CC-TA) with AgNO 3 solution as the silver source, where CC-TA was prepared by the cross-linking polymerization of tannin-based pre-polymer and cellulose. The tannin introduced onto the cellulose backbone was used as a reduction reagent for silver ions and a stabilizing agent for AgNPs. The AgNPs are uniform, and the average size is about 6.44 � 3.19 nm. The catalytic activity of AgNPs supported on cellulose-immobilized tannin resin(CC-TA@AgNPs)was detected by the reaction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). This reaction could be accomplished within 1.5 min with an apparent rate constant of 2.32 min À 1 . The CC-TA@AgNPs has good cycle catalytic performance, and the conversion rate of 4-NP to 4-AP in the presence of CC-TA@AgNPs is about 100 % after five consecutive cycles. Therefore, the CC-TA@AgNPs is expected to be a promising catalytic material.

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Antioxidant and Antibacterial Activities of Dodecyl Tannin Derivative Linked with 1,2,3‐Triazole

Cited by 7 publications

References 29 publications

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Phytochemical Characterization, Antioxidant and Anti-Inflammatory Effects of Cleome arabica L. Fruits Extract against Formalin Induced Chronic Inflammation in Female Wistar Rat: Biochemical, Histological, and In Silico Studies

Preparation of Silver Nanoparticles Supported on Cellulose‐Immobilized Tannin Resin and Its Catalytic Activity

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