Antioxidant and anticancer activity of extract from Betula platyphylla var. japonica

Phenolic compounds were extracted from Mallotus philippinensis bark using methanol. Six fractions (I-VI) were separated from the extract on a Sephadex LH-20 column using ethanol and acetone-water as the mobile phases and were evaluated for their total antioxidant activity, antiradical activity against DPPH• (2,2-diphenyl-1-picrylhydrazyl radical), and reducing power. The total phenolics and tannin contents in the fractions were determined. The content of total phenolics in the fractions ranged from 54 mg/g (fraction I) to 927 mg/g (fraction VI). Condensed tannins were detected in fractions II-VI. Total antioxidant activity (TAA) of phenolic fractions of Mallotus philipinensis bark extract ranged from 0.58 mmol Trolox/g (fraction I) to 6.82 mmol Trolox/g (fraction IV). Fraction IV also showed the strongest antiradical activity against DPPH • and reducing power. Several phenolic constituents in the fractions were detected by RP-HPLC using a gradient solvent system with UV-DAD detection.

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“…Ju et al (2004) reported the extract from the dried bark of Betula platyphylla var. japonica as a strong DPPH…”

Section: Resultsmentioning

confidence: 99%

Antioxidant activity of phenolic fractions of Mallotus philippinensis bark extract

Arfan¹,

Amin²,

Karamać³

et al. 2009

Czech J. Food Sci.

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“…EO concentration 2.5 µg/mL demonstrated maximum cytoprotective activity against IC 50 and IC 70 H 2 O 2 cytotoxicity. In the study by Ju et al (2004), treatment with Betula platyphylla var. japonica extract for 1 h prior to the addition of 100 µM of H 2 O 2 induced a dose-dependent increase in cell survival.…”

Section: Resultsmentioning

confidence: 99%

Effects of Thymus revolutus Célak essential oil and its two major components on Hep G2 cells membrane

Erdoğan

Özkan

2012

Biologia

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In this study pro/anti-oxidant activities of Thymus revolutus Célak (T. revolutus C.) essential oil and its two main components on Hep G2 cells were determined. Twelve components were identified in T. revolutus C. essential oil by GC and GC-MS and the main components of the oil were cymene (32.57%) and γ-terpinene (17.18%). The essential oil showed more cytotoxicity than its two main components on Hep G2 after 24, 48 and 72 hours incubations. Membrane damage effects of the essential oil and its two main components on Hep G2 cells were increased by incubation with IC10, IC50 and IC70 concentrations. Lower essential oil (

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“…Meanwhile, H 2 O 2 partially mediates the toxicity of Aβ, the major pathological hallmark for AD (Behl et al, 1994). Therefore, H 2 O 2 has been adopted extensively to induce the apoptosis of various cells (Park et al, 2003;Ju et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Cellular Antioxidant Activity and Pharmacokinetic Study of Polymethoxylated Flavonoids in Extract of Citrus reticulata ‘Chachi’ Peel

Yuen

Hwang

Zhang

et al. 2014

FSTR

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Antioxidant and anticancer activity of extract from Betula platyphylla var. japonica

Cited by 86 publications

References 39 publications

Antioxidant activity of phenolic fractions of Mallotus philippinensis bark extract

Antioxidant activity of phenolic fractions of Mallotus philippinensis bark extract

Effects of Thymus revolutus Célak essential oil and its two major components on Hep G2 cells membrane

Cellular Antioxidant Activity and Pharmacokinetic Study of Polymethoxylated Flavonoids in Extract of Citrus reticulata ‘Chachi’ Peel

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