Antioxidant and antidiabetic activities of various solvent extracts from Stachys sieboldii Miq.

Kang, Jae-Ran; Kang, Min‐Jung; Shin, Ji-Hyeon; Park, Ji-Hye; Kim, Dong-Il; Chung, S.; Shin, Jung-Hye

doi:10.11002/kjfp.2017.24.5.615

Cited by 11 publications

(1 citation statement)

References 33 publications

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“…However, due to inefficiency, cost, and side effects, the present medications have limitations in their use (Saravanakumar et al, 2021). The extracts and essential oils of various Stachys species have previously been tested for antidiabetic activity (Bahadori, Maggi, Zengin, Asghari, & Eskandani, 2020;Bursal, Taslimi, Gören, & Gülçin, 2020;Kang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Investigation of enzyme inhibition potentials, and antioxidative properties of the extracts of endemic Stachys bombycina Boiss.

Ayaz¹,

Eruygur²

2022

ijp

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Background and Aims:The genus Stachys L., is represented by around 300 species worldwide. More than 120 taxa, almost 60 of which are endemic, are widely distributed in Turkey, particularly in the eastern and southern regions. Stachys species have traditionally been used for many diseases such as asthma, rheumatism, cough, genital tumors, ulcers, diabetes, hemorrhoids, kidney stones, and various mental disorders. Among the species, S. bombycina Boiss., namely "arıçayçesi" in Turkish, is one of the near-threatened endemic perennial herbs. Methods: The antioxidant activity of methanol and water extracts of S. bombycina was examined utilizing in vitro techniques, including radical scavenging, such as DPPH, and ABTS, an iron-chelating assay, and the total phenol (TPC) and flavonoid contents (TFC). The extracts were also investigated on enzyme inhibition effects using in vitro spectrophotometric method. HPLC analysis was also used for the determination of the phytochemical profiles of the extracts. Results: Based on our results, the methanol extract of S. bombycina demonstrated higher DPPH and ABTS radical scavenging activity with the IC 50 value of 605.7 ± 1.04 and 19.40 ± 0.37 µg/mL, respectively, than the water extract. Otherwise, the water extract was found to have a higher iron chelating activity (IC 50 = 917.9 ± 3.55 µg/mL) than the methanol extract. The highest TPC of the water extract was determined as 81.07 ± 4.71 µg GAE/mg, although the methanol extract had more TFC at 46.93 ± 1.94 µg QE/mg. In addition, high anti-BChE activity was observed (IC 50 = 58.09 ± 1.18 µg/mL) in the water extract. In addition, ellagic acid was defined as a major component in the methanol extract, while caffeic acid was detected as the main compound in the water extract. Conclusion: Consequently, the current study is the first to report the antioxidant and enzyme inhibitory properties of S. bombycina. According to our findings on S. bombycina, this work can contribute to the development of bioactive agents from natural sources. Moreover, further investigations still need to be conducted on the discovery of the phytoconstituents of S. bombycina responsible for the bioactivity, as well as its potential various biological activities.

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Section: Introductionmentioning

confidence: 99%

Investigation of enzyme inhibition potentials, and antioxidative properties of the extracts of endemic Stachys bombycina Boiss.

Ayaz¹,

Eruygur²

2022

ijp

View full text Add to dashboard Cite

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Comparison of the physicochemical properties of native and cultivated Artemisia fukudo Makino

Kang,

Kim,

Kim

et al. 2024

Food Sci. Preserv.

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Artemisia fukudo Makino belongs to the Asteraceae family, is a halophyte that can grow in salinity soils and is known for its various physiological activities. However, few studies were comparing it according to the growth environment. Therefore, in this study, we analyzed the antioxidant activity, functional ingredients, and safety of Artemisia fukudo Makino according to the growth environment. Total polyphenol content was the highest in native mature leaves, but 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity was higher in cultivated leaves than in native leaves. The total mineral content, excluding sodium, was higher in cultivated than in native leaves. The content of potassium and calcium was higher in cultivated leaves than in native leaves. In addition, heavy metal analysis showed that cultivated leaves were generally lower than those of native leaves. Residual pesticides were not detected in all samples. In conclusion, since there is no significant difference in cultivated leaves compared to native leaves, it was judged that cultivated leaves could be used as a variety to be grown and mass-produced.

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Antioxidant and anti-inflammatory activities of extracts from Ledum palustre L.

Kim¹

2017

Korean Journal of Food Preservation

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In this study, Ledum palustre L. was extracted by 4 different methods (LPW, hot water extraction; LPA, autoclave extraction; LPU, ultrasonification extraction; LPE, 70% ethanol extraction) and LPE was fractionated by using polarity difference of each solvent and used as 4 samples (LPE/H, the n-hexane layer; LPE/E, the EtOAc layer; LPE/B, the n-BuOH layer; LPE/W, the H2O layer). Antioxidant activities of Ledum palustre L. extracts were measured by DPPH and ABTS. As a result, the DPPH and ABTS radical scavenging showed high activities with LPE (82.3%, 99.8%) and LPE/E (91.8%, 99.6%) at the concentration of 1,000 μg/mL. The anti-inflammatory activities of LPE and LPE/E were measured by the inhibitory activity against NO, PGE2, TNF-α, IL-1β and IL-6 production on LPS-stimulated Raw 264.7 macrophages. As a result of MTT assay, cell viabilities of LPE and LPE/E were more than 90% at 25 μg/mL. NO and PGE2 productions were inhibited by LPE (NO: 50%, PGE2: 70%) and LPE/E (NO: 57%, PGE2: 73%) at the concentration of 25 μg/mL. The inhibition activities against TNF-α, IL-1β, IL-6 production were 24%, 47% and 40% at the concentration of 25 μg/mL of LPE. In particular, LPE/E showed 51%, 57% and 62% inhibition activities at the same concentration, respectively. From the above results, it can be concluded that 1,000 μg/mL of LPE and LPE/E have the high antioxidant activities similar with Vitamin C, and 25 μg/mL, the low concetration of LPE and LPE/E have excellent anti-inflammatory activities. Therefore, if more research about anti-aging, whitening and antimicrobial activity of Ledum palustre L. extracts is carried out in the future, it will be possible to use them as effective materials for the prevention and treatment of inflammatory diseases and in the areas of functional foods and cosmetics.

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Antioxidant and antidiabetic activities of various solvent extracts from Stachys sieboldii Miq.

Cited by 11 publications

References 33 publications

Investigation of enzyme inhibition potentials, and antioxidative properties of the extracts of endemic Stachys bombycina Boiss.

Investigation of enzyme inhibition potentials, and antioxidative properties of the extracts of endemic Stachys bombycina Boiss.

Comparison of the physicochemical properties of native and cultivated Artemisia fukudo Makino

Antioxidant and anti-inflammatory activities of extracts from Ledum palustre L.

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