Antioxidant and antidiabetic activity of <i>Andrographis paniculata</i> and <i>Rhinacanthus nasutus</i> in isoniazid and rifampicin induced Wistar rats

Abstract

The present investigation aimed to identify the effects of ethanolic extract of &lt;i&gt;Andrographis paniculata&lt;/i&gt; Linn. and &lt;i&gt;Rhinacanthus nasutus&lt;/i&gt; Kurz. on enzymatic and non-enzymatic antioxidants on isoniazid and rifampicin induced Wistar rats. Animals were randomly divided into nine groups of 6 rats each and housed in individually ventilated cages for further experimental procedure. The levels of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-s-transfersase (GST), lipid peroxides (LPO), reduced glutathione (GSH), vitamin C (vit C) and vitamin E (vit E) and carbohydrate metabolism parameters of glucose, glycogen, glucose-6-phosphatase, glucose-6-phosphatase dehydrogenase and hexokinase are estimated at the end of the study. The present study results highlighted that the leaves extract of &lt;i&gt;A. paniculata&lt;/i&gt; and &lt;i&gt;R. nasutus&lt;/i&gt; have an antioxidant effect and anti-diabetic activity against the toxin treated rats.