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The present investigation was aimed to identify the potentiality of <i>Euphorbia thymifolia</i> Linn. and <i>Euphorbia hirta</i> Linn. leaf extract on the toxin-induced (carbon tetrachloride - CCl₄) Albino Wistar rats. The animals were grouped into 7 categories including control (basal diet, G1), CCl₄-induced (1.5 mL/kg, b.w., i.p.) (G2), G1 administrated with 300 mg/kg b.w., extract of <i>E. thymifolia</i> (G3) and <i>E. hirta</i> (G4), G2 administrated with 300 mg/kg b.w., extract of <i>E. thymifolia</i> (G5), <i>E. hirta</i> (G6), and standard drug (silymarin 25 mg/kg b.w.; G7) for 21-days trial period with each group contains 6 rats. The samples were collected and the following parameters including mitochondrial enzymes, different ATPase and lipid profiles were analyzed. The membrane-bound enzymes, the mitochondrial enzymes levels and the lipid profiles were reduced in the toxin-induced rats but the levels of enzymes were restored, significantly increased and lipid profiles are returned to the normal in the treatment of both extracts.

The present investigation aimed to identify the effects of ethanolic extract of <i>Andrographis paniculata</i> Linn. and <i>Rhinacanthus nasutus</i> Kurz. on enzymatic and non-enzymatic antioxidants on isoniazid and rifampicin induced Wistar rats. Animals were randomly divided into nine groups of 6 rats each and housed in individually ventilated cages for further experimental procedure. The levels of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-s-transfersase (GST), lipid peroxides (LPO), reduced glutathione (GSH), vitamin C (vit C) and vitamin E (vit E) and carbohydrate metabolism parameters of glucose, glycogen, glucose-6-phosphatase, glucose-6-phosphatase dehydrogenase and hexokinase are estimated at the end of the study. The present study results highlighted that the leaves extract of <i>A. paniculata</i> and <i>R. nasutus</i> have an antioxidant effect and anti-diabetic activity against the toxin treated rats.