Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study

Sarian, Murni Nazira; Ahmed, Qamar Uddin; So’ad, Siti Zaiton Mat; Alhassan, Alhassan Muhammad; Murugesu, Suganya; Perumal, Vikneswari; Mohamad, Sharifah Nurul Akilah Syed; Khatib, Alfi; Latip, Jalifah

doi:10.1155/2017/8386065

Cited by 267 publications

(197 citation statements)

References 57 publications

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“…On the other hand, only flavonoids (i.e., anthocyanins, flavanols, flavonols, and flavones) were found to be highly correlated to the enzymatic inhibition tested, with the most significant values (p < 0.01) recorded for flavanols (Supplementary Materials). These results are consistent with recent papers, which reported that flavonoids are one of the most important classes of natural enzyme inhibitors [43][44][45]. Finally, when considering the C. szovitsii flower extracts, we found negative correlation coefficients between the total alkaloids and the in vitro antioxidant assays (mainly with FRAP and ABTS values of −0.92 and −0.90, respectively).…”

Section: Correlationssupporting

confidence: 92%

Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

et al. 2019

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Like other members of the Colchicum genus, C. szovitsii subsp. szovitsii is also of medicinal importance in Turkish traditional medicine. However, its biological properties have not been fully investigated. Herein, we focused on the evaluation of the in vitro antioxidant and enzyme inhibitory effects of flower, root and leaf extracts, obtained using different extraction methods. In addition, a comprehensive (poly)-phenolic and alkaloid profiling of the different extracts was undertaken. In this regard, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) allowed us to putatively annotate 195 polyphenols and 87 alkaloids. The most abundant polyphenols were flavonoids (83 compounds), whilst colchicine and 2-demethylcolchicine were some of the most widespread alkaloids in each extract analyzed. However, our findings showed that C. szovitsii leaf extracts were a superior source of both total polyphenols and total alkaloids (being, on average 24.00 and 2.50 mg/g, respectively). Overall, methanolic leaf extracts showed the highest (p < 0.05) ferric reducing antioxidant power (FRAP) reducing power (on average 109.52 mgTE/g) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (on average 90.98 mgTE/g). Interestingly, each C. szovitsii methanolic extract was more active than the water extracts when considering enzymatic inhibition such as against tyrosinase, glucosidase, and acetylcholinesterase (AChE). Strong correlations (p < 0.01) were also observed between polyphenols/alkaloids and the biological activities determined. Multivariate statistics based on supervised orthogonal projections to latent structures discriminant analysis (OPLS-DA) allowed for the detection of those compounds most affected by the different extraction methods. Therefore, this is the first detailed evidence showing that C. szovitsii subsp. szovitsii might provide beneficial effects against oxidative stress and the associated chronic diseases. Nevertheless, the detailed mechanisms of action need to be further investigated.

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Section: Correlationssupporting

confidence: 92%

Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

et al. 2019

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“…Bilberry leaf chemical composition usually consists of flavonoids, proanthocyanidins, triterpenes, and also phenolic compounds, in particular, of myricetin, which revealed an effectiveness at the DM2 initial stages of according to some authors [43,44].…”

Section: The Study Of the Blueberry (Vaccinium Myrtillus L) Extractmentioning

confidence: 99%

Prospects for Using the Natural Antioxidant Compounds in the Obesity Treatment

Zagayko¹,

Briukhanova²,

Лыткин³

et al. 2019

Antioxidants

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Obesity is strongly associated with the insulin resistance development and is an integral pathogenic part of the metabolic syndrome, type 2 diabetes, atherosclerosis, and other comorbid pathologies. It is well known that the obesity causes the disorders in adipose tissue endocrine and metabolic activity, which results in the activation of free radical processes. The administration of natural origin substances with antioxidant properties could be a promising direction for obesity and overweight correction. The objective of the current study was to evaluate the usefulness of natural origin active substances with antioxidant properties' administration under the obesity and comorbid disorder treatment. This chapter presents the results of experimental studies that proved the usefulness of phenolic compounds from apple food concentrate (Malus domestica L.) and dry bilberry extract (Vaccinium myrtillus L.) application under experimental metabolic syndrome, insulin resistance syndrome, and type 2 diabetes mellitus, which are extremely associated with obesity. It has been found that due to expressive antioxidant activity, these compounds exhibit the high efficiency in carbohydrate metabolism disorders' correction (in cases of metabolic syndrome and type 2 diabetes), lipids metabolism disorders' correction (in case of metabolic syndrome), preventing of endothelial dysfunction under experimental insulin resistance, and normalization of antioxidant status in the liver (under experimental type 2 diabetes mellitus).

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“…It was evident that higher concentration of phenolics as well as flavonoids highly soluble in polar solvent like water 12 . They mainly acts as antioxidant activity and also plays vital role in antidiabetic activity due to presence of hydroxyl groups, some double bonds (C-2-C-3) and C-4 ketonic functional groups in their structures 13,14 . Therefore it was essential to determine the total flavonoids and phenolics contents in AEDN leaf.…”

Section: Estimation Of Total Flavonoids and Total Phenolicsmentioning

confidence: 99%

Phytochemical screening and establishment of antidiabetic potentiality of aqueous leaf extract of endangered plant <i>Decalepis nervosa</i> in alloxan induced diabetic rats

Das¹,

M²,

Sounder³

et al. 2019

tjps

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Objective: To evaluate the presence of phytochemicals in AEDN plant species (Aqueous leaf extract of Decalepis nervosa) and antidiabetic activity in normal and alloxan induced diabetic rats. Materials and Methods: Either sex rats were grouped into 5 classes. Alloxan monohydrate was used as induced diabetic whereas glibenclamide was used as standard drug. Medicinal endangered plant DN aqueous extract was used with two different doses. Diabetes was induced with Alloxan monohydrate at 150 mg/kg B.w. The AEDN was standardized with Pharmacognostical and phytochemical screening and chemical test confirmed the presence of phytoconstituents like glycoside, alkaloid, phenols, and flavonoids. Acute toxicity was performed for dose selection in antidiabetic study. Results: Glibenclamide at 5 mg/kg b.w. and AEDN (200 mg and 400 mg) extract were given to all diabetic induced rats. The reduction of the blood glucose level may have correlation with the presence of plant secondary metabolites (phenolic compounds) which was identified by TLC and confirmed by HPLC studies. The decreased level of serum total cholesterol, triglyceride and liver enzymes activity resulted dose dependency of AEDN extract. OGTT was performed by administration of 200 mg and 400 mg of aqueous extract of DN and 5 mg of glibenclamide to different groups respectively which significantly lower after oral glucose load during blood sample collection. Animal body weight and dose of AEDN extract showed significant effect on blood glucose level (**P<0.01). Conclusion: The first report on the phytochemicals and therapeutic activity of AEDN leaf was established with potential antidiabetic activity by increased insulin secretion via enhanced peripheral glucose utilization mechanism.

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Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study

Cited by 267 publications

References 57 publications

Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

Prospects for Using the Natural Antioxidant Compounds in the Obesity Treatment

Phytochemical screening and establishment of antidiabetic potentiality of aqueous leaf extract of endangered plant <i>Decalepis nervosa</i> in alloxan induced diabetic rats

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