Antioxidant and Antiinflammatory Activities of Anthocyanins and Their Aglycon, Cyanidin, from Tart Cherries

Wang, Haibo; Nair, Muraleedharan G.; Strasburg, Gale M.; Chang, Yu-Chen; Booren, A. M.; Gray, J. I.; DeWitt, David L.

doi:10.1021/np990184z

Cited by 351 publications

(200 citation statements)

References 7 publications

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“…A potent scavenger of these free radical species may therefore serve as a possible prevention intervention for free radical mediated cancer (Ames et al, 1995). The efficacies of various anti-oxidants have been associated with their ability to scavenge free radicals (Wang et al, 1999). In the present study, the crude ethanolic extract of ginger was found to exhibit radical scavenging activity with potency comparable to that of the standard compound ascorbic acid with median IC 50 of 27.86 and 21.38 μg/ml, respectively.…”

Section: Discussionmentioning

confidence: 55%

Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma

Plengsuriyakarn¹,

Viyanant²,

Eursitthichai³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cholangiocarcinoma (CCA) is an uncommon adenocarcinoma which arises from the epithelial cells of the bile ducts. The aim of the study was to investigate the cytotoxicity, toxicity, and anticancer activity of a crude ethanolic extract of ginger (Zingiber officinale Roscoe) against CCA. Cytotoxic activity against a CCA cell line (CL-6) was assessed by calcein-AM and Hoechst 33342 assays and anti-oxidant activity was evaluated using the DPPH assay. Investigation of apoptotic activity was performed by DNA fragmentation assay and induction of genes that may be involved in the resistance of CCA to anticancer drugs (MDR1, MRP1, MRP2, and MRP3) was examined by real-time PCR. To investigate anti-CCA activity in vivo, a total of 80 OV and nitrosamine (OV/ DMN)-induced CCA hamsters were fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days. Control groups consisting of 10 hamsters for each group were fed with 5-fluorouracil (positive control) or distilled water (untreated control). Median IC 50 (concentration that inhibits cell growth by 50%) values for cytotoxicity and anti-oxidant activities of the crude ethanolic extract of ginger were 10.95, 53.15, and 27.86 μg/ml, respectively. More than ten DNA fragments were visualized and up to 7-9 fold up-regulation of MDR1 and MRP3 genes was observed following exposure to the ethanolic extract of ginger. Acute and subacute toxicity tests indicated absence of any significant toxicity at the maximum dose of 5,000 mg/kg body weight given by intragastric gavage. The survival time and survival rate of the CCA-bearing hamsters were significantly prolonged compared to the control group (median of 54 vs 17 weeks). Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity. Moreover, MDR1 and MRP3 may be involved in conferring resistance of CCA to the ginger extract.

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Section: Discussionmentioning

confidence: 55%

Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma

Plengsuriyakarn¹,

Viyanant²,

Eursitthichai³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Among the 20 most commonly to be high in numerous phytonutrients [4,5]. Data support the presence of several phytonutrients in procyanidins, and anthocyanins [6].…”

mentioning

confidence: 71%

“…been previously shown that tart cherries attenuate circulating inflammatory markers [8,9,4], improve recovery…”

mentioning

confidence: 99%

Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro

et al. 2015

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“…Because of their high carotenoids content potatoes are particularly beneficial for eye health [22], [23]. Lutein, zeaxanthin, violaxanthin and neoxanthin are the major carotenoids present in potatoes and β-carotene is present in trace amounts [24].…”

Section: Introductionmentioning

confidence: 99%

Carotenoids and Phenols of Organically and Conventionally Cultivated Potato Varieties

Mūrniece¹,

Krūma²,

Skrabule³

et al. 2013

IJCEA

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Abstract-Many of the compounds present in potato are important because of their beneficial effects on health, therefore, are highly desirable in the human diet. The orange and yellow colour of the tuber flesh is due to carotenoids. The aim of this research was to determine the content of total phenolic content and carotenoids in relationship with the colour of organically and conventionally cultivated potato varieties before and after period of storage. In the research 31 potato samples of 12 potato varieties were analyzed on total carotenoid, total phenolic content and colour. Obtained results show that there was significant influence on carotenoid content between different cultivation environments (p<0.05) and between varieties (p<0.05). Total phenolic content significantly varies both per variety (p<0.001) and storage conditions (p<0.001).

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Antioxidant and Antiinflammatory Activities of Anthocyanins and Their Aglycon, Cyanidin, from Tart Cherries

Cited by 351 publications

References 7 publications

Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma

Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma

Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro

Carotenoids and Phenols of Organically and Conventionally Cultivated Potato Varieties

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