Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma

Plengsuriyakarn, Tullayakorn; Viyanant, Vithoon; Eursitthichai, Veerachai; Tesana, Smarn; Chai่jaroenkul, Wanna; Itharat, Arunporn; Na‐Bangchang, Kesara

doi:10.7314/apjcp.2012.13.9.4597

Cited by 54 publications

(50 citation statements)

References 58 publications

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“…Therefore, kidney cells were used in the study. Limited genotoxicity data were available for the herbs included in this study, with the exception of data from a small number of prior studies conducted to assess their antimutagenic/anticarcinogenic potentials (49)(50)(51)(52)(53)(54)(55).…”

Section: Discussionmentioning

confidence: 99%

Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey

Asadi¹,

Nath²,

Özhan³

2015

Turk J Med Sci

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IntroductionSince ancient times, herbs have played an important role in the treatment of different diseases in many regions of world, largely for their expectorant, aphrodisiac, diuretic, diaphoretic, antispasmodic, stomachic, and sedative properties (1). The World Health Organization reported that 70%-80% of the global population relies on herbs for primary health care. In addition, because they are natural products, it is generally believed that herbs are essentially safe and free from side effects. Consequently, the consumption of nonprescription herbs has steadily increased over the past few decades (2).Despite the therapeutic advantages of herbs, reports have indicated the potential toxicity of some herbal components. Herbs contain a variety of chemical substances that act upon the body. In addition, the quality of herbs can be affected by toxic contaminants originating from industry, agriculture, and private households, including toxins that can cause mutagenic and carcinogenic effects from long-term and widespread use (3-6). Moreover, herbal medicines are generally a mixture of a number of herbs in a single preparation and contain several active ingredients that induce various pharmacological effects (7,8). To date, there are few scientific studies on the safety and potential toxicity of herbs, despite growing concerns over the lack of both scientific evidence and quality control data regarding the safety and efficacy of herbs (9,10).Sexual dysfunction is a condition that affects 15-30 million men worldwide, and it occurs in 10%-52% of men and 25%-63% of women (11,12). Many believe that sexual dysfunction is associated with the modern lifestyle. As a result, individuals turn to natural products, such as traditional herbs, that produce aphrodisiac effects for sexual enhancement. Aphrodisiac herbs are used to treat sexual dysfunction because they alter specific neurotransmitters or sex hormones. Specifically, herbs with aphrodisiac properties can induce vasodilatation that results in a sustained erection, and can cause irritation of genital mucosa that enhances sensory experience during coitus (13).Background/aim: Sexual dysfunction is a serious problem worldwide. In Turkey, herbal products are used by some people suffering from sexual dysfunction. Despite their therapeutic advantages, some constituents of herbs are potentially toxic and pose health risks because they can be bought from the market without a prescription. Therefore, we aimed to determine the safety of herbs possessing aphrodisiac effects, chosen on the basis of their frequency of medicinal use and commercial importance in Turkey. Materials and methods:Ten herbs (Anethum graveolens, Carthamus tinctorius, Citrus aurantium, Cocos nucifera, Glycyrrhiza glabra, Melissa officinalis, Nigella arvensis, Pinus pinea, Prunus mahaleb, and Zingiber officinale) were extracted with water, methanol, and chloroform. The cyto-and genotoxic potentials of the extracts were assessed using an MTT test on a rat kidney cell line and an Ames assay in Salmonella typhi...

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Section: Discussionmentioning

confidence: 99%

Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey

Asadi¹,

Nath²,

Özhan³

2015

Turk J Med Sci

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“…DC., Zingiber officinale Roscoe and Piper chaba Hunt. (Mahavorasirikul et al ., ; Na‐Bangchang and Karbwang, ; Plengsuriyakarn et al ., ; Plengsuriyakarn et al ., ). Herbal medicines are mixtures of more than one active ingredient, and therefore, the likelihood of drug–herb interaction is theoretically higher than drug–drug interaction as synthetic drugs usually contain single chemical entities.…”

Section: Introductionmentioning

confidence: 97%

Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450

2015

Self Cite

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Malaria and cholangiocarcinoma remain important public health problems in tropical countries including Southeast Asian nations. Newly developed chemotherapeutic and plant-derived drugs are urgently required for the control of both diseases. The aim of the present study was to investigate the propensity to inhibit cytochrome P450-mediated hepatic metabolism (CYP1A2, CYP2C19, CYP2D6 and CYP3A4) of the crude ethanolic extract of eight Thai medicinal plants with promising activities against malaria and cholangiocarcinoma, using human liver microsomes in vitro. Piper chaba Linn. (PC) and Atractylodes lancea (thung.) DC. (AL) exhibited the most potent inhibitory activities on CYP1A2-mediated phenacetin O-deethylation with mean IC50 of 0.04 and 0.36 µg/mL, respectively. Plumbago indica Linn. (PI) and Dioscorea membranacea Pierre. (DM) potently inhibited CYP2C19-mediated omeprazole 5-hydroxylation (mean IC50 4.71 and 6.92 µg/mL, respectively). DM, Dracaena loureiri Gagnep. (DL) and PI showed the highest inhibitory activities on dextromethorphan O-demethylation (mean IC50 2.93-9.57 µg/mL). PC, DM, DL and PI exhibited the most potent inhibitory activities on CYP3A4-mediated nifedipine oxidation (mean IC50 1.54-6.43 µg/mL). Clinical relevance of the inhibitory potential of DM, PC and PI is of concern for the further development of these plants for the treatment of malaria and/or cholangiocarcinoma.

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“…Moreover, MDR1 and MRP3 may be involved in conferring resistance of CCA to ginger extract [17]. Result showed that ethanolic extract produced remarkable reduction in number of viable cells (p < 0.01) and increased the percentage of life span.…”

Section: Premanathan Et Al (2012)mentioning

confidence: 97%

Medicinal plants: used in Anti-cancer treatment

Tyagi¹,

Sharma²,

Shrivastava³

et al. 2017

IJRDPL

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ABSTRACT:Globally cancer is a disease which severely effects the human population. There is a constant demand for new therapies to treat and prevent this life -threatening disease. The plant kingdom produces naturally occurring secondary metabolites which are being investigated for the anticancer activities for the development of new clinical drugs. For many years herbal medicines have been used and are still used in developing countries as the primary source of medical treatment. Plants have been used in the medicine for their natural antiseptic properties. Thus, research has developed into the investigating the potential properties and uses of terrestrial plants extracts for the preparation of potential nanomaterial drugs for diseases including cancer. Many plant species are already being used to treat or prevent development of cancer. This review discusses the demand for naturally derived compounds from medicinal plants and their properties which make them targets for potential anticancer treatments.

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Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma

Cited by 54 publications

References 58 publications

Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey

Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey

Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450

Medicinal plants: used in Anti-cancer treatment

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