Antioxidant and antiinflammatory effect of <i>Epilobium parviflorum</i> Schreb.

Hevesi, B. T.; Houghton, Peter J.; Habtemariam, Solomon; Kéry, Ágnes

doi:10.1002/ptr.2725

Cited by 38 publications

(27 citation statements)

References 22 publications

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“…Moreover, a single fraction HF 11–14b showed significant anti-inflammatory activity. Diverse studies have demonstrated that different members of the Onagraceae family have selective anti-inflammatory activity in animal models [7, 8, 15, 27] and cytotoxic activities against several tumor cell lines [11, 12, 28–30]. …”

Section: Discussionmentioning

confidence: 99%

“…Among flavonoids, isolated compounds from this family include flavonols, glycoflavones, flavones, and chalcones [13, 14]. Most of the genera studied possess mainly flavonols, which include myricetin, quercetin, kaempferol, and remarkable amounts of various phenolic acids [6, 7, 15]. Furthermore, some species produce significant amount of tocopherols, compounds that have been used as chemotaxonomic markers within the Onagraceae family [16].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial, Antiparasitic, Anti‐Inflammatory, and Cytotoxic Activities of Lopezia racemosa

Cruz-Paredes

Balbás

Gómez‐Velasco

et al. 2013

The Scientific World Journal

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The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts and fractions were tested against a panel of nine bacterial and four fungal species. The antiparasitic activity was tested against Leishmania donovani, whereas the anti-inflammatory activity of the compounds was determined by measuring the secretion of interleukin-6 from human-derived macrophages. The same macrophage cell line was used to investigate the cytotoxicity of the compounds. Various extracts and fractions showed antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. The hexanic fraction HF 11-14b was the most interesting fraction with antimicrobial, and anti-inflammatory activities. The benefit of L. racemosa as a traditional medicinal plant was confirmed as shown by its antibacterial, antifungal and anti-inflammatory activities. To the best of our knowledge, this is the first study reporting the biological activities of L. racemosa, including antiparasitic and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial, Antiparasitic, Anti‐Inflammatory, and Cytotoxic Activities of Lopezia racemosa

Cruz-Paredes

Balbás

Gómez‐Velasco

et al. 2013

The Scientific World Journal

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“…Active compounds have not been identified (Hiermann, Juan, & Sametz, ; Juan, Sametz, & Hiermann, ). Either ethanolic or aqueous acetone extract of E. parviflorum has inhibited in vitro COX‐1 and COX‐2 enzymes, involved in the prostaglandin biosynthesis (Hevesi et al, ; Steenkamp, Gouws, Gulumian, Elgorashi, & van Staden, ), decreasing prostaglandin E 2 release (Hevesi et al, ). Furthermore, its dichloromethane extract has demonstrated a moderate inhibition of NF‐kB (Vogl et al, ).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Epilobium spp: Pharmacology and Phytochemistry

Vitalone

Allkanjari

2018

Phytotherapy Research

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The Epilobium species and their extracts are very popular in folk medicine, for a wide range of applications. The purpose of this review is the analysis of the pharmacological properties of Epilobium spp, considering whether their effects (e.g., anti-inflammatory, antioxidant, antitumor, antimicrobial, analgesic, and antiandrogenic) could rationally justify the use of Epilobium as a treatment of numerous diseases. Even if numerous preclinical studies have been reported, randomized controlled clinical trials (for the evaluation of safety and efficacy), and eventually cost-effectiveness studies (to estimate the long-term cumulative costs), are still needed to confirm the usefulness of these medicinal plants in human diseases.

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“…[23][24][25] Various herbal extracts reduce oxidative stress in testosterone-induced BPH rats. [26][27][28][29] In addition, saw palmetto extract, which is commonly used to treat BPH, has shown antioxidant effects. 30 Therefore, antioxidants can be considered good candidates to suppress the development of BPH.…”

mentioning

confidence: 99%

Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats

Lee¹,

Shin²,

Seo³

et al. 2012

Asian J Androl

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Benign prostatic hyperplasia (BPH) is an age-related disease of unknown aetiology characterized by prostatic enlargement coincident with distinct alterations in tissue histomorphology. Instead of therapeutic agents that can cause severe side effects, plant extracts are frequently used to treat BPH. In this study, we investigated whether the Melandrium firmum methanolic extract (MFME) improves BPH, using the testosterone propionate (TP)-induced BPH rat model. Castration was performed via the scrotal route under sodium pentobarbital anaesthesia. BPH in castrated rats was generated via daily subcutaneous injections of TP (3 mg kg 21 ) dissolved in corn oil, for 4 weeks. MFME was administered daily by oral gavage at a dose of 200 mg kg 21 for 4 weeks, along with the TP injections. The control group received injections of corn oil subcutaneously. At the scheduled termination of the experiment, all rats were killed and their prostates weighed; the relative prostate weight (prostate/body weight ratio) was calculated, and histomorphological changes in the prostate were examined. Additionally, we measured the levels of testosterone and dihydrotestosterone (DHT) in the serum and the prostate. Experimentally induced BPH led to marked decreases in the relative prostate weight and the DHT levels in the serum and the prostate. Histologically, BPH was evident in the ventral lobe of the prostate, and MFME treatment suppressed the severity of the lesions. These results indicate that MFME effectively inhibits the development of BPH induced by testosterone in a rat model. Further studies will be needed to identify the compound(s) responsibility for inducing the protective effect against BPH and determine its mechanism of action.

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Antioxidant and antiinflammatory effect of Epilobium parviflorum Schreb.

Cited by 38 publications

References 22 publications

Antimicrobial, Antiparasitic, Anti‐Inflammatory, and Cytotoxic Activities of Lopezia racemosa

Antimicrobial, Antiparasitic, Anti‐Inflammatory, and Cytotoxic Activities of Lopezia racemosa

Epilobium spp: Pharmacology and Phytochemistry

Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats

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