Antioxidant and Antiplasmodial Activities of Extracts from &amp;lt;i&amp;gt;Gardenia erubescens&amp;lt;/i&amp;gt; Stapf et Hutch. and &amp;lt;i&amp;gt;Fadogia agrestis&amp;lt;/i&amp;gt; Schweinf. ex Hiern. (Rubiaceae)

Combasséré-Chérif, Mariama Kaba; Belem, Hadidjatou; Koama, Benjamin Kouliga; Sawadogo, Assetou; Da, Sandrine Nadège; Kagambéga, Windmi; Drabo, Anne-Flora; Meda, Roland Nâg-Tiéro; Ouédraogo, George Anicet

doi:10.4236/ojapps.2020.1011047

Cited by 3 publications

(2 citation statements)

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“…The antioxidant activity of the plants is related to the presence of phenolic compounds such as total polyphenols and flavonoids as well as condensed tannins [24]. Our results are similar to those obtained by [25], who obtained variable phenolic compound content with aqueous and ethanolic extracts of different plant parts with quite high antioxidant activity. Several fractions of the different parts of Nauclea latifolia obtained quite high antioxidant activity similar to our results [26].…”

Section: Discussionsupporting

confidence: 89%

Antioxidant Activity and Phenolic Compounds Content of Extracts from </>Ceratotheca sesamoides Endl and Striga hermonthica (Delille) Benth Used as Antheminthic in Burkina Faso

Dıcko¹,

Sami²,

Belem³

et al. 2022

JBM

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The revaluation of medicinal plants in the veterinary pharmacopoeia is essential for the development of livestock in Burkina Faso. In order to justify the use of C. sesamoides and S. hermonthica in the treatment of gastrointestinal parasitosis of small ruminants, a quantification of phenolic compounds as well as antioxidant activity and acute toxicité evaluation of both plants were performed. Acute toxicity was evaluated by administering a single dose of 2000 mg/kg body weight of aqueous extract of both plants to mice. The highest total polyphenol content for C. sesamoides was obtained in the ethyl acetate fraction with 47.236 ± 2.57 mgEAG/100mg while that of S. hermonthica was 74.871 ± 2.57 mgEAG/100mg obtained with the n-butanol Fraction. The dichloromethane extract of S. hermonthica obtained the highest total flavonoid content with 7.31 ± 0.48 mgEQ/ 100 while the highest total flavonoid content of C. sesamoides was obtained with ethyl acetate fraction with 5.4273 ± 0.35 mgEQ/100mg. The aqueous extract of C. sesamoides obtained the highest content of condensed tannins with 3.028 ± 0.13 mgEAT/100mg. Both plant's extracts did not show any signs of toxicity in NMRI mice after administration of the dose of 2000 mg/kg.

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Section: Discussionsupporting

confidence: 89%

Antioxidant Activity and Phenolic Compounds Content of Extracts from </>Ceratotheca sesamoides Endl and Striga hermonthica (Delille) Benth Used as Antheminthic in Burkina Faso

Dıcko¹,

Sami²,

Belem³

et al. 2022

JBM

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“…In traditional practice, the root of the plant is utilized as an aphrodisiac while the aerial parts are applied in the management of gonorrhea and insomnia by herbalists (17,18). The plant was also reported to exert moderate antioxidant, anti-obesity, and anti-plasmodial activity (14,19). The application of in silico studies including molecular docking, molecular dynamics, and ADMET significantly improves the drug discovery and development process paving the way for wet lab and reducing cost and time in identifying lead compounds from a library of compounds.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profiling, heavy metals composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens

Badgal,

Dahiru,

Musa

2023

sciphy

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This study aimed to explore the phytochemical profile, heavy metal composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens due to its folkloric acclaimed aphrodisiac use. The phytochemicals were quantified gravimetrically while the identification of bioactive compounds was carried out using a combined Gas spectrophotometer-mass spectrophotometer (GC-MS). Heavy metals were quantified using an atomic absorption spectrophotometer while the aphrodisiac and ADMET studies were in silico. The result showed the presence of alkaloids (22.33% ±1.45), saponins (20.17% ±1.88), glycosides (0.55% ±0.03), and flavonoids (32.67% ±1.45), with the absence of steroids and terpenoids. GC-MS analysis identified 25 compounds with linoleic acid having the highest peak area (28.01%) next to palmitic acid (14.08%). Chromium, Cadmium, and Lead were present in concentrations of 0.145 ±0.03, 0.001 ±0.00, and 0.065 ±0.03 ppm respectively. Ethyl D-glucopyranoside had the least BA (-8) and Ki (1.35 µM) docked with human arginase II while Tyrosinol had the least BA (-6.2) and Ki (28.21 µM) docked with phosphodiesterase 5 though both were higher than Sildenafil citrate. All the top docked compounds were predicted to be neither substrates nor inhibitors of P-glycoproteins and cytochrome P450 enzymes without CNS permeability and hepatotoxicity. Conclusively, the present study supports the folkloric aphrodisiac application of Gardenia erubescens, and the heavy metals level was below the acceptable regulatory level, thus, might be safe for occasional use. Additionally, the identified compounds might be considered a novel source of therapeutics against erectile dysfunction.

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In vitro Antiplasmodial Properties of Five Antimalarial Plants Used in Burkina Faso

Assé,

Harouna,

Roland

et al. 2023

J. of Pharmacology and Toxicology

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Antioxidant and Antiplasmodial Activities of Extracts from <i>Gardenia erubescens</i> Stapf et Hutch. and <i>Fadogia agrestis</i> Schweinf. ex Hiern. (Rubiaceae)

Cited by 3 publications

References 20 publications

Antioxidant Activity and Phenolic Compounds Content of Extracts from </>Ceratotheca sesamoides</i> Endl and <i>Striga hermonthica</i> (Delille) Benth Used as Antheminthic in Burkina Faso

Antioxidant Activity and Phenolic Compounds Content of Extracts from </>Ceratotheca sesamoides</i> Endl and <i>Striga hermonthica</i> (Delille) Benth Used as Antheminthic in Burkina Faso

Phytochemical profiling, heavy metals composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens

In vitro Antiplasmodial Properties of Five Antimalarial Plants Used in Burkina Faso

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Antioxidant and Antiplasmodial Activities of Extracts from &lt;i&gt;Gardenia erubescens&lt;/i&gt; Stapf et Hutch. and &lt;i&gt;Fadogia agrestis&lt;/i&gt; Schweinf. ex Hiern. (Rubiaceae)

Cited by 3 publications

References 20 publications

Antioxidant Activity and Phenolic Compounds Content of Extracts from &lt;/&gt;Ceratotheca sesamoides&lt;/i&gt; Endl and &lt;i&gt;Striga hermonthica&lt;/i&gt; (Delille) Benth Used as Antheminthic in Burkina Faso

Antioxidant Activity and Phenolic Compounds Content of Extracts from &lt;/&gt;Ceratotheca sesamoides&lt;/i&gt; Endl and &lt;i&gt;Striga hermonthica&lt;/i&gt; (Delille) Benth Used as Antheminthic in Burkina Faso

Phytochemical profiling, heavy metals composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens

In vitro Antiplasmodial Properties of Five Antimalarial Plants Used in Burkina Faso

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Antioxidant and Antiplasmodial Activities of Extracts from <i>Gardenia erubescens</i> Stapf et Hutch. and <i>Fadogia agrestis</i> Schweinf. ex Hiern. (Rubiaceae)

Antioxidant Activity and Phenolic Compounds Content of Extracts from </>Ceratotheca sesamoides</i> Endl and <i>Striga hermonthica</i> (Delille) Benth Used as Antheminthic in Burkina Faso

Antioxidant Activity and Phenolic Compounds Content of Extracts from </>Ceratotheca sesamoides</i> Endl and <i>Striga hermonthica</i> (Delille) Benth Used as Antheminthic in Burkina Faso