Antioxidant and antiproliferative activities of proanthocyanidins from Chinese bayberry ( Myrica rubra Sieb. et Zucc.) leaves

Zhang, Yu; Zhou, Xiaozhou; Tao, Wenyang; Li, Lanqi; Wei, Chaoyang; Duan, Jie; Chen, Shiguo; Ye, Xingqian

doi:10.1016/j.jff.2016.10.004

Cited by 59 publications

(40 citation statements)

References 31 publications

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“…Gut microbiota could also metabolize cranberries to produce some phenolic acids (for example, benzoic acid) and phenylvalerolactone metabolites, which were also contributive to the improvement of infection and inflammation in the gut (Monagas et al., ). (b) Antioxidant activity: in vitro chemical assays have shown the strong antioxidant ability of proanthocyanidins due to the existence of several hydroxyl groups to quench free radicals (Zhang et al., ). Proanthocyanidins have also been observed to maintain the oxidative balance by scavenging hydroxyl, superoxide, and peroxyl radicals in vivo (Georgiev, Ananga, & Tsolova, ).…”

Section: Health Benefits Of Proanthocyanidinsmentioning

confidence: 99%

“…(d) Anticancer activity: a number of studies used different sources of proanthocyanidins as the treatment against different types of cancer both in vitro and in vivo . Studies found that proanthocyanidins inhibit the growth of some common cancer cells, such as hepatic cancer cells (Zhang et al., ), ovarian cancer cells (Y. Zhang et al., ), and breast cancer cells (Chen et al., ), and so on, by targeting various signaling pathways that play important roles in tumor proliferation and metastasis, such as Wnt‐catenin, Hedgehog, Akt, Erk, and p53 pathways. Xenograft animal models also further supported similar results by showing smaller tumor size and improved metabolic parameters (Akhtar, Meeran, Katiyar, & Katiyar, ; Prasad, Vaid, & Katiyar, ; Sharma, Meeran, & Katiyar, ).…”

Section: Health Benefits Of Proanthocyanidinsmentioning

confidence: 99%

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Rethinking the Mechanism of the Health Benefits of Proanthocyanidins: Absorption, Metabolism, and Interaction with Gut Microbiota

Tao

Zhang

Shen

et al. 2019

Comp Rev Food Sci Food Safe

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101

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Proanthocyanidins, as the oligomers or polymers of flavan‐3‐ol, are widely discovered in plants such as fruits, vegetables, cereals, nuts, and leaves, presenting a major part of dietary polyphenols. Although proanthocyanidins exert several types of bioactivities, such as antioxidant, antimicrobial, cardioprotective, and neuroprotective activity, their exact mechanisms remain unclear. Due to the complexity of the structure of proanthocyanidins, such as their various monomers, different linkages and isomers, investigation of their bioavailability and metabolism is limited, which further hinders the explanation of their bioactivities. Since the large molecular weight and degree of polymerization limit the bioavailability of proanthocyanidins, the major effective site of proanthocyanidins is proposed to be in the gut. Many studies have revealed the effects of proanthocyanidins from different sources on changing the composition of gut microbiota based on in vitro and in vivo models and the bioactivities of their metabolites. However, the metabolic routes of proanthocyanidins by gut microbiota and their mutual interactions are still sparse. Thus, this review summarizes the chemistry, absorption, and metabolic pathways of proanthocyanidins ranging from monomers to polymers, as well as the mutual interactions between proanthocyanidins and gut microbiota, in order to better understand how proanthocyanidins exert their health‐promoting functions.

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Section: Health Benefits Of Proanthocyanidinsmentioning

confidence: 99%

Section: Health Benefits Of Proanthocyanidinsmentioning

confidence: 99%

Rethinking the Mechanism of the Health Benefits of Proanthocyanidins: Absorption, Metabolism, and Interaction with Gut Microbiota

Tao

Zhang

Shen

et al. 2019

Comp Rev Food Sci Food Safe

Self Cite

101

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“…et Zucc.) has been cultivated in Southern China for more than 2,000 years [6], and China is also a major country for bayberry output, with the annual amount around 300,000 tons [7]. Leaves from Chinese bayberry trees are luxuriant and remain green throughout a year.…”

Section: Introductionmentioning

confidence: 99%

Chemical and Cellular Assays Combined with In Vitro Digestion to Determine the Antioxidant Activity of Flavonoids from Chinese Bayberry (Myrica rubra Sieb. et Zucc.) Leaves

et al. 2016

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Oxidative stress is highly associated with the development of cardiovascular diseases and cancer and has drawn great attention. Natural products suggest a potential role in prevention of these disorders. The aim of this study was to investigate the antioxidant and anti-cancer properties of Chinese bayberry leaves (Myrica rubra Sieb. et Zucc.) flavonoids (BLF) comprehensively through the combination of in vitro digestion, chemical and cellular antioxidant assays. Based on the LC/MS data, the major flavonoids of BLF were myricitrin and quercetin 3-rhamnoside. BLF owned strong chemical and cellular antioxidant activity (CAA) with its CAA value at 4253.884 ± 435.366 μmol of QE/100 g DW. After the in vitro digestion, the total flavonoids content, myricitrin and quercetin 3-rhamnoside decreased significantly (P < 0.05). Lower levels of the total flavonoid content and cellular uptake of myricitrin and quercetin 3-rhamnoside might contribute to the lower CAA value of digested BLF (DBLF). However, DBLF still owns considerable chemical antioxidant activities and CAA compared with many plants. Furthermore, both BLF and DBLF exhibited dose-dependent relationship against HepG2 proliferation. Taken together, BLF has a great potential to be developed as a natural antioxidant for promoting public health.

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“…The HepG2 and LNcap cells were grown in Dulbecco's Modified Eagle's Medium (DMEM), which were supplemented with 10% fetal bovine serum, 50 units/mL streptomycin, and 100 units/mL penicillin in a humidified (5% CO 2 , 95% air) atmosphere at 37°C. The MTT cytotoxicity assay was performed according to the method (Zhang et al, ). Cells (1 × 10 4 cells/well) were seeded for 12 hr in 96‐well plates.…”

Section: Methodsmentioning

confidence: 99%

Polyphenols extract from lotus seedpod (Nelumbo nucifera Gaertn.): Phenolic compositions, antioxidant, and antiproliferative activities

Shen

Guan

Song

et al. 2019

Food Science & Nutrition

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Seedpod, the nonedible portion of lotus (Nelumbo nucifera Gaertn.), was reported to be rich in polyphenols. The objective of this study was to investigate the major bioactive polyphenols of the lotus seedpods. The total polyphenol content (TPC) from ethanol extract of lotus seedpod (PELS) was found to be 34.23 μg gallic acid equivalents (GAE)/mg extract. Four polyphenolic compounds were identified in the PELS, comprised of one flavan‐3‐ol (catechin) and three flavonoids (kaemferol, quercetin and hyperoside). In vitro antioxidant and antiproliferative properties of the PELS were evaluated. PELS exhibited 89.38%, 99.82%, 68.25%, and 95.82% scavenging activities against 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), superoxide, hydroxyl, and 2,2ʹazinobis‐3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) radicals, respectively, at 1.6 mg/ml. The Fe3+ reducing power of PELS was 0.605 at 0.32 mg/ml, which is comparable to glutathione (GSH). The PELS showed 31.79% metal chelating capacity and 87.79% inhibition of linoleic acid auto‐oxidation at 1.6 mg/ml. PELS showed cytotoxicity toward HepG2 and LNcap cell lines in vitro with IC50 values at 44.59 and 11.50 μg/ml, respectively. The findings of this study provide evidences that the inedible lotus seedpod could be a source for natural antioxidants and anticancer agents.

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Antioxidant and antiproliferative activities of proanthocyanidins from Chinese bayberry ( Myrica rubra Sieb. et Zucc.) leaves

Cited by 59 publications

References 31 publications

Rethinking the Mechanism of the Health Benefits of Proanthocyanidins: Absorption, Metabolism, and Interaction with Gut Microbiota

Rethinking the Mechanism of the Health Benefits of Proanthocyanidins: Absorption, Metabolism, and Interaction with Gut Microbiota

Chemical and Cellular Assays Combined with In Vitro Digestion to Determine the Antioxidant Activity of Flavonoids from Chinese Bayberry (Myrica rubra Sieb. et Zucc.) Leaves

Polyphenols extract from lotus seedpod (Nelumbo nucifera Gaertn.): Phenolic compositions, antioxidant, and antiproliferative activities

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