Antioxidant and Bone; Protect Your Future: A Brief Review

Mottaghi, Peyman; Nasri, Parto

doi:10.18502/ijph.v50i9.7049

Cited by 10 publications

(9 citation statements)

References 16 publications

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“…In conclusion, we verified the therapeutic effect of bentonite complex by tissue repair process in minipig burn wound model. Recently, bentonite clay has been recognised as common and familiar materials in human life (Moosavi, 2017; Srasra & Bekri‐Abbes, 2020). Thus, this study provides a scientific basis for developing bentonite‐based products for medical and cosmetic use.…”

Section: Discussionmentioning

confidence: 99%

Regenerative and anti‐inflammatory effect of a novel bentonite complex on burn wounds

Lee

Choi

Song

et al. 2022

Veterinary Medicine & Sci

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BackgroundBentonite, a montmorillonite clay, has been used as a classical remedy strategy for a long time. Recently, bentonite has been used as a raw material in cosmetic products because of its antibacterial and antioxidant properties. However, the therapeutic effect of bentonite on burn injuries has not yet been identi ed. Here, we explored the therapeutic effect of a novel bentonite complex, which was developed for medical use, on burn wounds and the anti-in ammatory function of bentonite clay in the complex in vitro. MethodsA novel bentonite complex and bentonite clay were provided by C&L Biotech Co., Ltd. (Seoul, Korea). The elements of bentonite clay were analysed using inductively coupled plasma optical emission spectroscopy. Burn wounds were induced on the dorsal skin of two Yucatan minipigs, and tissue regeneration was determined by cell proliferation, angiogenesis, and collagen deposition using immunohistochemistry and Masson's trichrome staining. Anti-in ammatory function was determined using quantitative real-time PCR and enzyme-linked immunosorbent assays. ResultsWe found that by inducing collagen synthesis, cell proliferation, and angiogenesis, the bentonite complex improved skin regeneration in burn wounds. It was also identi ed that the expression of in ammatory cytokines associated with cyclooxygenase 2 (COX-2) signalling was signi cantly inhibited by treatment of the burn wounds with the bentonite complex. An in vitro study to identify the anti-in ammatory effect of bentonite clay, a major component of the bentonite complex, showed that COX-2 signalling was signi cantly regulated in both HacaT keratinocytes and 3D4/2 macrophage cell lines in vitro. ConclusionsThis study identi ed the therapeutic effect of a novel bentonite complex in burn wounds by inducing skin regeneration and bentonite-mediated anti-in ammatory responses with bentonite complex treatment.

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Section: Discussionmentioning

confidence: 99%

Regenerative and anti‐inflammatory effect of a novel bentonite complex on burn wounds

Lee

Choi

Song

et al. 2022

Veterinary Medicine & Sci

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“…Recent appraisals of the medicinal and cosmetic uses of African clays include the works of Masango et al, 2017;Gomes, 2018;Williams, 2019;Incledion et al, 2021;Morekhure-Mphahlele et al, 2017and Buthelezi-Dube et al, 2022and Kgabi and Ambushe, 2023 Further research is needed to distinguish between 'healing clays' and those identified as antibacterial clays, for, as Williams and Haydel noted in 2010: "… the highly adsorptive properties of many clays may contribute to healing a variety of ailments, although they are not antibacterial." See also : Moosavi, 2017;Nomicisio et al, 2023. According to Cao (2022: "Functionalization of fibrous clays and their organic modified derivatives for high value-added dermopharmaceutical and cosmetic applications is currently an active area of research.…”

Section: Medicinal Clays and Cosmetic Productsmentioning

confidence: 99%

Beneficial Effects of Geological Materials: With Africa Case Descriptions

Olarewaju,

Fajinmi,

Davies

et al. 2024

Preprint

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Studies on Medical Geology have up till recently tended to emphasise the harmful effects of geological material and processes. This is perhaps justifiable, given the realisation that many environmental diseases could have causal links with some geo-environmental variables as co-factors, making such studies extremely valuable in the improvement of diagnoses and therapy. However, this review aims to show that in addition to the high value of such research, studies conducted on the beneficial properties of Earth materials also have considerable merit, given their enormous potential for assuaging a wide range of environmental health disorders. For instance, certain geological materials including clay minerals contain active substances that show considerable promise in various applications such as pharmaceutical formulations, aesthetic medicine, and indigenous medicine. This review synthesises current knowledge of how certain geological materials can be exploited in formulating remedies for some human health problems. Reports of the therapeutic uses of clay minerals, zinc oxide (zincite), zeolite, and kaolin are appraised. The review shows that ancient and contemporary use of geological materials such as clay minerals have played crucial roles in the treatment of several human diseases, with recent and ongoing research revealing further development in these applications. Well strategised clinical trials using available resources could give impetus to further research in elucidating the potential of various geomaterials as innovative clinical remedies for some human diseases and infections as well as aid the proper scientific documentation of their natural uses.

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“…The role of clay minerals (e.g., bentonite clay, attapulgite) as a base for certain pharmaceuticals (digestive aid; anti-diarrhoeal medicines) should be further researched. As Moosavi ( 135 ) writes: “As traditional remedies seem to have a deep root in maintaining body health, it merits doing more research works on bentonite clay and its impacts on body function.”…”

Section: Suggested Areas For Further Researchmentioning

confidence: 99%

Current status of research and gaps in knowledge of geophagic practices in Africa

Davies

2023

Front. Nutr.

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This article synthesises current knowledge and identifies research gaps on the still intriguing aspects of the subject of geophagy as practised in Africa. Despite the voluminous research literature that exists on the subject, geophagy in Africa is still a largely misunderstood phenomenon. Although the practice is not confined to any particular age group, race, gender, or geographical region, in Africa it is most commonly recorded among pregnant women and children. Till now, the precise aetiology of geophagy remains obscure; but the practice is thought to have both beneficial effects such as having a role as a nutrient supplement, as well as several demerits. An updated critical review of human geophagy in Africa - with a section on (other) animal geophagy -, highlights several aspects of the practice that need further research. A comprehensive bibliography is assembled, comprising some of the more pertinent and recently published papers (mostly post-dating the year 2005), as well as older seminal works, providing a baseline and robust framework for aiding the search process of Medical Geology researchers and those from allied fields wanting to explore the still poorly understood aspects of geophagy in Africa.

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Antioxidant and Bone; Protect Your Future: A Brief Review

Cited by 10 publications

References 16 publications

Regenerative and anti‐inflammatory effect of a novel bentonite complex on burn wounds

Regenerative and anti‐inflammatory effect of a novel bentonite complex on burn wounds

Beneficial Effects of Geological Materials: With Africa Case Descriptions

Current status of research and gaps in knowledge of geophagic practices in Africa

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