Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn.

Kelm, Mark A.; Nair, Muraleedharan G.; Strasburg, Gale M.; DeWitt, David L.

doi:10.1016/s0944-7113(00)80015-x

Cited by 344 publications

(212 citation statements)

References 20 publications

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“…The ability of the extract from O. basilicum to inhibit COX-2 was determined and the results show that the extract was not capable to reduce the activity of the cyclooxygenase like the positive control (ibuprofen) but his activity decrease when compared to the negative control (100%) and was dose-dependent. The inhibition of COX-2 in LD50 and LD50/10 approximates to the inhibition caused by rosmarinic acid and several studies report many properties of rosmarinic acid including cyclooxygenase inhibition (Kelm et al, 2000;Petersen, Simmonds, 2003).…”

Section: Resultsmentioning

confidence: 94%

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Evaluation of basil extract ( Ocimum basilicum L.) on oxidative, anti-genotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents

Güez

Souza

Fischer

et al. 2017

Braz. J. Pharm. Sci.

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Ocimum is one of the most important genera of the Lamiaceae family. Several studies about basil and its popular use reveal many characteristics of the herb, including its use as antioxidant, anti-aging, antiinflammatory, anti-carcinogenic, anti-microbial, and cardiovascular agents, among others. In this paper, we evaluated genotoxic, oxidative, and anti-inflammatory parameters from the extract of Ocimum basilicum in different concentrations, using human leukocytes cultures exposed to challenging agents. Our results confirm that the O. basilicum extract acts as an antioxidant and effectively reverts or subjugates the effects of high oxidizing agents such as hydrogen peroxide. These actions are attributed to its composition, which is rich in polyphenols and flavonoids as well as compounds such as rosmarinic acid, all of which have well-known antioxidant activity. We also show that our basil extract presents anti-inflammatory properties, the mechanism of which is a composed interaction between the inhibition of pro-inflammatory mediator and the stimulation of anti-inflammatory cytokines. Although pharmacodynamics studies are necessary to evaluate the activities in vivo, our results demonstrated that basil could act as an antioxidant and anti-inflammatory and a possible alternative for medicinal treatment. Uniterms:Ocimum basilicum/evaluation. Ocimum basilicum/genotoxic effects. Ocimum basilicum/ anti-inflammatory properties. Medicinal plants/study.

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Section: Resultsmentioning

confidence: 94%

“…Polyphenols are a first line of defense against oxidative action of hydrogen peroxide. When polyphenols decrease their concentrations, other non-enzymatic antioxidants come into play, thereby reducing the concentration of vitamin C (Kelm et al, 2000;Petersen, Simmonds, 2003).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of basil extract ( Ocimum basilicum L.) on oxidative, anti-genotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents

Güez

Souza

Fischer

et al. 2017

Braz. J. Pharm. Sci.

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“…The stem and leaves of Tulsi contain a variety of phytochemical constituents that may have biological activity, including saponins, flavonoids, triterpenoids, and tannins. [12][13][14] In addition, the following phenolic actives -Rosmarinic acid, apigenin, cirsimaritin, isothymusin and isothymonin have been identified, which also exhibit antioxidant and antiinflammatory activities.…”

Section: Discussionmentioning

confidence: 99%

Activity of Tulsi leaves (Ocimum sanctum linn) in protecting gastric ulcer in rats by cold restrain method

Vaseem

Ali

Afshan

2017

Int J Basic Clin Pharmacol

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Background: Tulsi (Ocimum sanctum L.) common household plant, a potent adaptogen has been used for its medicinal property for many years. It is known in Ayurveda as Incomparable one, Mother of medicine of Nature and The Queen of Herbs. The present study evaluated the stress induced anti-ulcer effect of tulsi leaves in albino rats.Methods: Albino rats were randomly, allocated to different experimental groups and aqueous leaf extract of Tulsi (Ocimum sanctum) is given for 7 days. Gastric ulcers were induced by cold restrain methods and results were compared with control using distilled water and standard drug Ranitidine.Results: The Anti-ulcer effect of aqueous extract of Tulsi was significant in a dose dependent manner with cold restraint model. The percentage of ulcer protection of Tulsi leaf extract at dose 100mg/kg is 68.85% and at dose of 200mg/kg showed 65.66% and the standard drug Ranitidine showed 78.23% ulcer protection which is significant (p <0.05).Conclusions: The study showed that when Tulsi (Ocimum sanctum) is given at dose 100-200mg/kg for 7 days i.e., pre-treatment in rats for anti-ulcer effect, it caused a significant reduction in the ulcer scores and ulcer index when compared with control group, as evidenced by the gross appearance and histological findings of gastric mucosa in rats. There were few signs of mucosal injury and the percentage of damage was less compared to control group. Serosal surface revealed very few dilated blood vessels and petechial hemorrhages and mucosal surface had few ulcers of varying sizes.

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“…It is suggested that all or some of these bioactive compounds may be responsible for hypoglycemic, antidyslipidemic and antioxidant effects of the medicinal plants [22,23]. Kelm et al [24,25] found that leaves and stems of Ocimum sanctum contains cirsilineol, cirsimaritin, isothymusin, isothymonin, apigenin, rosmarinic acid, and appreciable quantities of eugenol and all these are known to possess potent lipid lowering and antioxidant activities. Suanarunsawat et al [26] also reported that feeding with essential Values are mean ± SD of six rats.…”

Section: Discussionmentioning

confidence: 99%

Antidyslipidemic Effect of Ocimum sanctum Leaf Extract in Streptozotocin Induced Diabetic Rats

et al. 2014

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The antidyslipidemic activity of Ocimum sanctum leaf extract was studied in streptozotocin induced diabetic rats. In this model, there was significant increase in plasma markers of diabetic-dyslipidemia following diminution of lipid metabolizing enzymes. Oral administration of leaf extract (500 mg/kg b.w.p.o.) for 15 days resulted in significant decrease in diabetogenic and dyslipidemia parameters; namely blood glucose, glycosylated hemoglobin, lipid peroxide, free fatty acids, small dense low density lipoprotein, lipid and protein components of plasma lipoproteins, adipose and liver. The regulation of lipids was accompanied by stimulation of postheparin lipolytic activity, reactivation of lecithin cholesterol acyl transferase and hepatic lipoprotein lipase enzymes. The results of the present study demonstrated antidyslipidemic and antioxidant activities in leaf extract of O. sanctum which could be used in prevention of diabeticdyslipidemia and related complications.

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Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn.

Cited by 344 publications

References 20 publications

Evaluation of basil extract ( Ocimum basilicum L.) on oxidative, anti-genotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents

Evaluation of basil extract ( Ocimum basilicum L.) on oxidative, anti-genotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents

Activity of Tulsi leaves (Ocimum sanctum linn) in protecting gastric ulcer in rats by cold restrain method

Antidyslipidemic Effect of Ocimum sanctum Leaf Extract in Streptozotocin Induced Diabetic Rats

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