Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Firdaus, Muhamad; Prihanto, Asep Awaludin; Nurdiani, Rahmi

doi:10.1016/s2221-1691(13)60017-9

Cited by 55 publications

(34 citation statements)

References 44 publications

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“…Ralf and Gerd [39] study also specify the presence of terpenoids, alkaloids, flavonoids, phenols, coumarins. Flower extracts disclose the occurrence of alkaloids, terpenoids, saponins, phenolics, flavonoids, tannins but the absence of steroids [40].…”

Section: Phytochemical Screeningmentioning

confidence: 99%

“…This study revealed that A. ilicifolius has significant bioactivities like, antioxidant and cytotoxic activity [26,55], antinociceptive activity [56], anti-inflammatory activity [23,26], anti-osteoporotic activity [57], hepatoprotective activity [26,58], chemopreventive activity [21]; leishmanicidal, tumour reducing and anticancer activities [26,58,59,60]; antileishmanial, antiulcer, antimicrobial, and osteoblastic, activities [26]. Moreover, Firdaus et al found in their study that flower extract of the plant also has good cytotoxic effects [40]; Smitha et al showed the anticancer activity of ethyl acetate extract of on two cell lines PA-1 and MCF-7 [61].…”

Section: Compound Isolationmentioning

confidence: 99%

“…Firdaus et al, [40] have scrutinized the antioxidant properties of A. ilicifolius by the DPPH scavenging assay. The assay was conducted on total five extracts (acetone, methanol, acetone 70%, methanol 80% and water) of flowers and found that methanol extract showed highest antiradical efficiency (141.30%), while water extract of showed lowest (0.0037%) among the extracts.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Firdaus et al, [40] analyzed the cytotoxic of the flower extracts of A. ilicifolius on the brine shrimp lethality. The results exhibited methanol extract has lowest LC50 value (22 μg/ml) while water extract showed the highest value at 10 μg/ml among the extracts.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

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Ethnomedicinal, Phytochemical, and Pharmacological Aspects of Genus Acanthus

Bora

Adhikari

Das

et al. 2017

Int J Pharm Pharm Sci

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Acanthus (family Acanthaceae) is a genus of the major group angiosperms (flowering plants) comprising more than 29 species widely distributed in the tropical and subtropical region. The aim of this review is to offer thorough scientific information on ethnomedicinal uses, phytochemical, and pharmacological activities of the plant species belonging to the genus Acanthus. Numerous traditional uses of the genus have been supported in this article from the results, and executed by the extracts and/or pure compounds obtained from pharmacological studies will provide a single platform to help future researches on the genus Acanthus. Furthermore, ethnomedicinal evaluation using fractions or isolation of medicinal principles was extensively explored by databases like Google, Google Scholar, and Science Direct at the same time.

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Section: Phytochemical Screeningmentioning

confidence: 99%

Section: Compound Isolationmentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

Section: Cytotoxic Activitymentioning

confidence: 99%

See 2 more Smart Citations

Ethnomedicinal, Phytochemical, and Pharmacological Aspects of Genus Acanthus

Bora

Adhikari

Das

et al. 2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

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“…drive the scientists to explore new and effective antimicrobial agents that could act as an alternative of the current regimens [13][14][15] . Cancer, a notorious disease of present time, has become the major cause of human mortality in the world, and approximately half of incidence and mortality occurs in Asia [16] . Nevertheless, accelerating numerous side effects, chemotherapeutic drugs are still regarded as the most effective treatments for cancer.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the antioxidant, antimicrobial, cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis

Islam

Ahmed

Manik

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights

Chowdhury,

Bhuia,

Al Hasan

et al. 2024

Food Science & Nutrition

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Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well‐being due to its substantial morbidity and death rates worldwide. The potential of plant‐derived natural compounds as anticancer medicines has been assessed owing to their favorable attributes of few side effects and significant antitumor activity. Mangrove plants and their derived compounds have been scientifically shown to exhibit many significant beneficial biological activities, such as anti‐inflammatory, immunomodulatory, antioxidant, neuroprotective, cardioprotective, and hepatoprotective properties. This study summarized mangrove plants and their derived compounds as potential anticancer agents, with an emphasis on the underlying molecular mechanisms. To explore this, we gathered data on the preclinical (in vivo and in vitro) anticancer effects of mangrove plants and their derived compounds from reputable literature spanning 2000 to 2023. We conducted thorough searches in various academic databases, including PubMed, ScienceDirect, Wiley Online, SpringerLink, Google Scholar, Scopus, and the Web of Science. The results demonstrated that mangrove plants and their derived compounds have promising anticancer properties in preclinical pharmacological test systems through various molecular mechanisms, including induction of oxidative stress and mitochondrial dysfunction, cytotoxicity, genotoxicity, cell cycle arrest, apoptosis, autophagy, antiproliferative, antimetastatic, and other miscellaneous actions. Upon thorough observation of the pertinent information, it is suggested that mangrove plants and their derived chemicals may serve as a potential lead in the development of novel drugs for cancer therapy.

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Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Cited by 55 publications

References 44 publications

Ethnomedicinal, Phytochemical, and Pharmacological Aspects of Genus Acanthus

Ethnomedicinal, Phytochemical, and Pharmacological Aspects of Genus Acanthus

A comparative study of the antioxidant, antimicrobial, cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis

Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights

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