Antioxidant and Cytotoxic Constituents from Wisteria sinensis

Abstract

Chromatographic separation of an aqueous MeOH extract of Wisteria sinensis leaves has yielded six known flavonoids, two triterpene aglycones and the new acylated flavone glycoside chrysoeriol-7-O-[2''-O-(5'''-O-caffeoyl)-β-D-apiofuranosyl]-β-D-glucopyranoside (1). All metabolites were isolated for the first time from the genus Wisteria. Their structures were established on the basis of their chromatographic properties, chemical and physicochemical methods including acid hydrolysis analysis, spectroscopic (UV, 1H- and 13C-NMR) data and confirmed by ESI-MS analysis, as well as two-dimensional NMR (1H-1HCOSY, HMQC and HMBC). Biological studies of the defatted aqueous 80% methanol leaf extract and the major isolates 1, 6 and 7 were undertaken and they are reported herein for the first time to have significant cytotoxic activity against the Hep-G2 tumor cell line in addition to antioxidant activity.

Antidiabetic effects of a lipophilic extract obtained from flowers of Wisteria sinensis by activating Akt/GLUT4 and Akt/GSK3β

“…The flowers of W. sinensis are used in many traditional Chinese cuisines, including the Chinese flower cake and Chinese flower jam. The extracts from plants belonging to the genus Wisteria reportedly have anti-oxidant, anti-tumor, and anti-inflammatory activities ( 13 – 15 ). In our knowledge, this is the first investigation to elucidate the potential antidiabetic activity of W. sinensis .…”

Comparison of the Polyamine Content of Five Spring Flowers with Wheat Germ as a Rich Anti-aging Polyamine Source for Preparation of Nutraceutical Products

“…It is a deciduous vine that grows to 20 - 30 meters (66 - 98 feet) and is extensively cultivated in the spring ( 15 ). W. sinensis leaves and flowers are also used as tea replacements ( 17 ). Many eastern pharmacists employ Wisteria gall extracts to treat patients with gastric cancer, breast cancer, and stomach cancer, as well as rheumatoid arthritis ( 18 , 19 ).…”

“…Its leaves can be used to distinguish it from L. periclymenum , the most prevalent species in Europe. The plant’s herbaceous parts can be a diuretic ( 17 , 22 ).…”

Structural analysis of oleanane‐type saponins from the roots of Wisteria frutescens

“…Wisteria (also spelled Wistaria ) is a genus of woody vines with alternate pinnately compound leaves and a large inflorescence of pendulous, showy purple, blue, or white flowers . Previous phytochemical studies were published on some Wisteria species: Triterpene saponins were isolated from the knots and vines of Wisteria brachybotrys and the leaves of Wisteria sinensis yielded flavonoid derivatives and triterpenes . Moreover, lectins from Wisteria floribunda were used for detection of tumor antigens with specific sugar chain and for diagnosis of cancer .…”