Antioxidant and Cytotoxic Flavonols from Calotropis procera

Abstract

3Phytochemical investigations of Calotropis procera leaves have led to the isolation of two new compounds: quercetagetin-6-methyl ether 3-O-β-D-4C1-galacturonopyranoside () and (E)-3-(4-methoxyphenyl-2-O-β-D-4C1-glucopyranoside)-methyl propenoate (4), along with eleven known metabolites: nine flavonol and two cinnamic acid derivatives. All metabolites were isolated for the first time from the genus Calotropis, except for 1 isolated previously from Calotropis gigantea. The structures were determined by spectroscopic methods (UV, ESI-MS, 1H, 13C NMR, 1H-1H COSY, HSQC, and HMBC). The radical scavenging activity of the aqueous methanol extract and compounds 8 - 13 was measured by the 1,1-diphenyl- 2-picrylhydrazyl (DPPH) method. Cytotoxic screening of the same compounds was carried out on brine shrimps as well

Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants

“…The flowers extract have been used for treating spleen, liver and abdomen diseases [ 16 ]. Additionally, various extracts of its different parts showed antibacterial and in-vitro and in-vivo antioxidant activities [ 17 – 20 ]. Earlier phytochemical investigation of C. procera revealed the presence of cardenolides, flavonoids, steroids and saponins [ 21 , 22 ].…”

Systematic Phytochemical Screening of Different Organs of Calotropis procera and the Ovicidal Effect of Their Extracts to the Foodstuff Pest Cadra cautella

“…Compounds 1-29 were tentatively identified as cardenolides by comparing their HPLC elution order, HR-MS data, and HR-MS/MS data with previously reported data ( Figure 2, Table 1) [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]. The cardenolide compounds exhibited very similar MS/MS spectra, i.e., several losses of H 2 O and CO, and for the glycoside compound, loss of the sugar unit [50]. Compounds 2, 3, 6, 8, and 10 showed a pseudo molecular ion at an m/z of 549.2622, which corresponded to the molecular formula of C 29 H 40 O 10 .…”

The first flavonoid isolated from Bromelia laciniosa (Bromeliaceae)

“…(Wollenweber et al, 2004), Pulicaria canariensis (Triana et al, 2005), Asteraceae spp. (Wollenweber et al, 2005), Artemisia campestris (Ferchichi et al, 2006), Scyphiphora hydrophyllacea (Dai et al, 2006), Artemisia rupestris (Song et al, 2006), Conyza blinii (Su et al, 2007), Jasonia montana belonging to Asteraceae (Soliman et al, 2009), Callicarpa nudiflora (Mei et al, 2010), Inula japonica (Qin et al, 2010), Blumea balsamifera (Chen et al, 2010), Callicarpa longipes (Gao et al, 2011), Calotropis procera (Mohamed et al, 2011), Callicarpa kwangtungensis (Jia et al, 2012) and Blumea balsamifera (Nguyen and Nguyen 2012). In summary, in concomitance with its widespread occurrence in quite diverse plant species, quercetin 3,3',4' trimethyl ether is not a compound unique to the Bromeliaceae family.…”