Antioxidant and Free Radical Scavenging Activity of Different Fractions from Hawthorn Fruit

Park, Jae Hyo; Li, Chunmei; Hu, Weicheng; Wang, Myeong‐Hyeon

doi:10.3746/jfn.2010.15.1.044

Cited by 5 publications

(5 citation statements)

References 47 publications

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“…Oxidative damage appears to be related to various diseases and inflammation conditions [18,19]. Polyphenols reduce oxidative stress and provide activity associated with anti-cancer, anti-allergic, and anti-inflammatory effects [20].…”

Section: Resultsmentioning

confidence: 99%

Anti-Oxidative and Anti-Proliferative Activity on Human Prostate Cancer Cells Lines of the Phenolic Compounds from Corylopsis coreana Uyeki

Kim

et al. 2013

Molecules

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Fifteen phenolic compounds, including three caffeoyl derivatives, four gallotannins, three ellagitannins and five flavonoids, were isolated from an 80% MeOH extract of the leaves of Corylopsis coreana Uyeki (Korean winter hazel; CL). The anti-oxidative activities [1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and xanthine oxidase superoxide scavenging activities (NBT)] and the anti-proliferative activity on human prostate cancer cell lines (DU145 and LNCaP) were also evaluated.

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Section: Resultsmentioning

confidence: 99%

Anti-Oxidative and Anti-Proliferative Activity on Human Prostate Cancer Cells Lines of the Phenolic Compounds from Corylopsis coreana Uyeki

Kim

et al. 2013

Molecules

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“…On the other hand, a high value for total phenolic content (343.5 mg GAE/g) in the ethyl acetate extract of C. monogyna leaves was reported by Öztürk et al [12]. Park et al [13] studied the ethyl acetate fraction of hawthorn berries, which were also characterized by high phenolic and flavonoid contents (140.2 tannic mg/g and 56.5 catechin mg/g, respectively). Literature data show significant differences in total phenolic content of hawthorn, probably due to several factors such as natural habitat, genotype, growth stage, extraction procedure and method for determination of total phenolics.…”

mentioning

confidence: 93%

Crataegus orientalis Leaves and Berries: Phenolic Profiles, Antioxidant and Anti-inflammatory Activity

Šavikin

Krstić-Milošević

Menković

et al. 2017

Natural Product Communications

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The present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC 50 = 29.7 µg/g) than the berry extract, as well as in the relative reducing power on Fe 3+. Anti-inflammatory potential was studied by means of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibitory activity; both extracts evinced activity. Furthermore, C. orientalis leaf extract showed a concentration dependent inhibition of COX-1 pathway products 12-HHT and TXB 2 , reaching IC 50 values below the lowest applied concentration (68.9% and 55.2% of 12-HHT and TXB 2 production inhibition, respectively, at concentration of 0.4 mg/mL). Although inhibitors such as acetylsalicylic acid and quercetin showed higher activity, this study demonstrates that the investigated extracts are potential anti-inflammatory agents.

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“…Recent reports have shown that hawthorn fruit exhibits anti-oxidant, anti-atherosclerotic, and hypolipidemic activities [ 17 - 20 ]. We previously reported on the antioxidant and anti-inflammatory properties of the methanolic extract of hawthorn fruit [ 21 , 22 ]. In this study, our objective was to investigate the mechanisms behind the anti-inflammatory activities of the water fractionated portion of hawthorn fruit on RAW 264.7 cells.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of the water fraction from hawthorn fruit on LPS-stimulated RAW 264.7 cells

Wang

2011

Nutr Res Pract

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The hawthorn fruit (Crataegus pinnatifida Bunge var. typica Schneider) is used as a traditional medicine in Korea. The objective of this study was to understand the mechanisms of the anti-inflammatory effects of the water fractionated portion of hawthorn fruit on a lipopolysaccharide (LPS)-stimulated RAW 264.7 cellular model. The level of nitric oxide (NO) production in the water fraction and LPS-treated RAW 264.7 cells were determined with an ELISA. The cytotoxicity of the water fraction and LPS was measured with an MTT assay. Expression of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-α, interleukin 6 (IL-6), and interleukin 1β (IL-1β) mRNA were analyzed with a reverse transcription polymerase chain reaction (RT-PCR). The water fraction of hawthorn fruit was determined to be safe and significantly inhibited NO production in LPS-stimulated RAW 264.7 cells and suppressed COX-2, TNF-α, IL-1β, and IL-6 expression. The observed anti-inflammatory effects of the water fraction of hawthorn fruit might be attributed to the down-regulation of COX-2, TNF-α, IL-1β, and IL-6 expression in LPS-stimulated RAW 264.7 cells.

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Antioxidant and Free Radical Scavenging Activity of Different Fractions from Hawthorn Fruit

Cited by 5 publications

References 47 publications

Anti-Oxidative and Anti-Proliferative Activity on Human Prostate Cancer Cells Lines of the Phenolic Compounds from Corylopsis coreana Uyeki

Anti-Oxidative and Anti-Proliferative Activity on Human Prostate Cancer Cells Lines of the Phenolic Compounds from Corylopsis coreana Uyeki

Crataegus orientalis Leaves and Berries: Phenolic Profiles, Antioxidant and Anti-inflammatory Activity

Anti-inflammatory effect of the water fraction from hawthorn fruit on LPS-stimulated RAW 264.7 cells

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