<i>Crataegus orientalis</i> Leaves and Berries: Phenolic Profiles, Antioxidant and Anti-inflammatory Activity

Šavikin, Katarina; Krstić-Milošević, Dijana; Menković, Nebojša; Beara, Ivana; Mrkonjić, Zorica; Pijevijakušić, Dejan S

doi:10.1177/1934578x1701200204

Cited by 13 publications

(11 citation statements)

References 26 publications

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“…However, this previous study reported a total phenolic content of 33.88 ± 0.28 mg GAE/g d.w. in other C. monogyna leaf extract obtained at other locations, which was 56.6% lower than that obtained in the present study [25]. Therefore, data show significant differences in total phenolic content of hawthorn due to several factors such as natural habitat, genotype, growth stage, extraction procedure and method for determination of total phenolics [24]. Figure 1A shows the maximum TPC in the range of 45-75% acetone/water and 55-75 min, whereas in Figure 1B its maximum concentration is observed at 50-70% acetone/water and 700-1200 solvent-to-solid ratio (v/w), and in Figure 1C its maximum value shows at 50-70 min and 700-1200 solvent-to-solid ratio (v/w).…”

Section: Optimization Of Ultrasonic-assisted Extractioncontrasting

confidence: 75%

“…The total phenolic content obtained in C. monogyna leaf extract at optimum conditions was in the magnitude order than a previous study in an extract of C. orientalis leaves, which was 94.2 mg GAE/g d.w. Nevertheless, this previous study reported an extraction in a Soxhlet apparatus for 72 h with 96% ethanol [24]. Therefore, it has been shown that ultrasonic-assisted extraction is more efficient than conventional extraction techniques due to requiring lower extraction times to obtain a similar phenolic recovery from Crataegus leaves.…”

Section: Optimization Of Ultrasonic-assisted Extractionmentioning

confidence: 99%

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Setup of an Ultrasonic-Assisted Extraction to Obtain High Phenolic Recovery in Crataegus monogyna Leaves

et al. 2021

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Hawthorn leaves are a rich source of phenolic compounds that possess beneficial activities for human health. Ultrasonic-assisted extraction (UAE) is an extraction technique frequently used for the isolation of phenolic compounds in plants. Thus, in this study, a Box–Behnken design was used to optimize UAE conditions such as the percentage of acetone, the extraction time and solvent-to-solid ratio (v/w) in order to obtain the maximum content of total compounds by Folin–Ciocalteu and the maximum in vitro antioxidant activity by DPPH, ABTS and FRAP assays in Crataegus monogyna leaves. The optimum conditions to obtain the highest total phenolic content and antioxidant activities were 50% acetone, 55 min and 1/1000 (w/v). A total of 30 phenolic compounds were identified and quantified in C. monogyna leaf extract obtained at these optimum UAE conditions. HPLC-MS allows the identification and quantification of 19 phenolic compounds and NP-HPLC-FLD analyses showed the presence of 11 proanthocyanidins. According to the results, the most concentrated phenolic compounds in C. monogyna leaf extract obtained at optimum UAE conditions were phenolic acid derivatives such as protocatechuic acid-glucoside, dihydroxy benzoic acid pentoside and chlorogenic acid, flavones such as 2″-O-rhamnosyl-C-hexosyl-apigenin, flavonols such as hyperoside and isoquercetin and proanthocyanidins such as monomer and dimer. As a result, the optimized UAE conditions could be used to obtain an extract of C. monogyna leaves enriched with phenolic compounds.

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Section: Optimization Of Ultrasonic-assisted Extractioncontrasting

confidence: 75%

Section: Optimization Of Ultrasonic-assisted Extractionmentioning

confidence: 99%

Setup of an Ultrasonic-Assisted Extraction to Obtain High Phenolic Recovery in Crataegus monogyna Leaves

et al. 2021

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“…In addition, Que reduces T cell proliferation by blocking IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4 (Muthian and Bright, 2004;Nabavi et al, 2012). In inflammation, Que inhibits the enzymes COX and lipoxygenase (Lee and Min, 2013;Savikin et al, 2017). In the RAW 264.7 cell line, Que was also shown to counteract LPSinduced inflammation by phosphorylation of tyrosine phosphatidylinositol-3-kinase (PI3K)-p85 and complex formation of toll-like receptor 4 (TLR4)/MyD88/PI3K (Endale et al, 2013).…”

Section: Quercetinmentioning

confidence: 99%

SIRT1 Activation by Natural Phytochemicals: An Overview

et al. 2020

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Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD + as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis. Deregulation of their expression and/or action may lead to tissue-specific degenerative events involved in the development of several human pathologies, including cancer, neurodegeneration, and cardiovascular disease. The most studied member of this class of enzymes is sirtuin 1 (SIRT1), whose expression is associated with increasing insulin sensitivity. SIRT1 has been implicated in both tumorigenic and anticancer processes, and is reported to regulate essential metabolic pathways, suggesting that its activation might be beneficial against disorders of the metabolism. Via regulation of p53 deacetylation and modulation of autophagy, SIRT1 is implicated in cellular response to caloric restriction and lifespan extension. In recent years, scientific interest focusing on the identification of SIRT1 modulators has led to the discovery of novel small molecules targeting SIRT1 activity. This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin. We will also discuss the potential therapeutic effects of these natural compounds in the prevention and treatment of human disorders, with particular emphasis on their metabolic impact.

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“…Flavonoid, epicatechin, chlorogenic acid (Sargin, 2015;Savikin et al, 2017) Leaf, Fruit Decoction Internal/drink one glass 2-3 times a day for 3-5 weeks Nephralgia, Kidney gravel (Sargin et al, 2015) Leaf, Fruit, Seed Raw, Mash, Decoction, Infusion…”

Section: Infusion Decoction Rawmentioning

confidence: 99%

Traditional herbal remedies used in kidney diseases in Turkey: an overview

Kültür¹,

Gürdal²,

Sarı³

et al. 2021

Turk J Bot

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Ethnobotanical and ethnomedicinal studies have become increasingly recognised as a valuable source of information on the use and possible pharmacological activity of many plant species. There is no study presenting traditional herbal remedies used for kidney diseases in Turkey. The purpose of the paper is to compile herbal remedies used in kidney diseases in Turkey with detailed usage information and chemical constituents.The botanical names, families, and local names; used parts; preparation methods; administration/dosage; kidney problems and chemical constituents were presented by screening ethnobotanical, ethnomedicinal and phytochemical studies. The most cited plant families, the most cited genera, and the most frequently used plant parts were determined and presented in graphics. In total, 300 taxa belonging to 70 families were 2 determined as being traditional herbal remedies used in kidney diseases. Asteraceae (57), Lamiaceae (33), Rosaceae (30), Fabaceae (16), Malvaceae (15), Apiaceae (13) and Poaceae (10) were found as the most cited plant families. The most cited genera were Helichrysum (44), Equisetum (27), Tribulus (23), Urtica (23), Rosa (17), Alcea (14), Hypericum (14) and Paliurus (14), respectively. It was found that the aerial parts were the most frequently used part of the plant, accounting for 28%. Following in this category are leaves (19%), flowers (14%), fruits (14%), underground parts (13%), seeds (5%), stem (3%), and other parts (4%). The pharmacological studies of the most cited genera were also reviewed to confirm the efficacy of these plants in the treatment of kidney diseases. It is concluded that a number of pharmacological and phytochemical research support the traditional usage of plants, but further studies are needed. Our findings are expected to be the basis for candidate pharmaceutical products.

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Crataegus orientalis Leaves and Berries: Phenolic Profiles, Antioxidant and Anti-inflammatory Activity

Cited by 13 publications

References 26 publications

Setup of an Ultrasonic-Assisted Extraction to Obtain High Phenolic Recovery in Crataegus monogyna Leaves

Setup of an Ultrasonic-Assisted Extraction to Obtain High Phenolic Recovery in Crataegus monogyna Leaves

SIRT1 Activation by Natural Phytochemicals: An Overview

Traditional herbal remedies used in kidney diseases in Turkey: an overview

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