Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena

Alam, M. Ashraful; Nyeem, Mab; Awal, MA; Mostofa, Md. Golam; Alam, Mahtab; Subhan, Nusrat; Rahman, MM

doi:10.3742/opem.2008.8.2.164

Cited by 28 publications

(20 citation statements)

References 12 publications

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“…22 Additionally, our results on preliminary screening of samples were confirmed the presence of flavonoids in R. damascena, B. vulgaris and C. intybus. Moreover, the presence of alkaloids and tannins was confirmed in some of the samples in this study.…”

Section: Discussionsupporting

confidence: 51%

Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk-e- Saghir, A Traditional Preparation, and Its Ingredients

Sarhadynejad¹,

Pardakhty²,

Mandegary³

et al. 2017

JYP

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Objective: Quality control and standardization of traditional preparations ensure their safe, pure and efficient prescription. Zereshk-e-Saghir (ZES), a folk remedy, has been recommended as a hepatoprotective agent in Traditional Persian Medicine (TPM). This study aimed at the evaluation of the physicochemical and phytochemical characterization, standardization, and in vitro antioxidant capacity determination of ZES and its ingredients. Method: Some qualitative and quantitative controls were performed like ash value, moisture content, extractable matter, phytochemical screening, TLC fingerprint and microbial contamination. Total phenolic and emodin contents of ZES were measured by spectrophotometric method to standardize this preparation. Finally in vitro radical scavenging activity of ZES and its ingredients were determined using 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) assay. Result: Regarding the physicochemical evaluation, the amount of each parameter (ash value, moisture content, and extractable value) was determined as documented characteristics for ZES components. Phytochemical screening of ZES ingredients indicated the presence of tannins in all the samples and the presence of alkaloids, steroids and terpenoids in a majority of the samples. Meanwhile, ZES exhibited no pathogenic contamination. The emodin and total phenolic contents (TPC) of ZES were reported 457.0 µg emodin/100g and 381.5 mg gallic acid equivalents (GAE)/100 g of ZES, respectively. Also TPC ranged from 3607.4 to 27.9 mg GAE/ 100 g of ZES ingredients. Meanwhile, the results demonstrated that ZES could scavenge DPPH radicals (IC 50 value: 266.4 µg/ ml). Conclusion: The obtained results on quality control and standardization of ZES could be proposed as a monograph having standard characteristics.

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Section: Discussionsupporting

confidence: 51%

Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk-e- Saghir, A Traditional Preparation, and Its Ingredients

Sarhadynejad¹,

Pardakhty²,

Mandegary³

et al. 2017

JYP

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“…In a study, they explained that Rosa damascene contains certain phytochemical metabolites including carboxylic acid, terpene, myrcene and vitamin C which are responsible for most of the beneficial activities of Rosa damascene [53]. Some reviewed that parts of Rosa damascena have carbohydrates 34%, proteins, alkaloids, saponins, fats and oils and phenolic compounds [21].…”

Section: Rosa Damascenamentioning

confidence: 99%

Phytochemical and Antioxidant Screening of Cassia Angustifolia,curcuma Zedoaria, Embelia Ribes, Piper Nigrum, Rosa Damascena,terminalia Belerica, Terminalia Chebula, Zingiber Officinale and Their Effect on Stomach and Liver

Zeeshan¹,

Barkat²,

Mahmood³

2018

Matrix sci. medica

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Herbal medicinal natural plants and species are mostly used for wide purposes in Pakistan in current situation. There are diverse variety of phytochemical constituents which are present in plants and act as secondary metabolites that are formed from the normal metabolism likewise alkaloids, flavonoids, glycoside, phenols, steroids and other specific pigments. Therefore, the botanist concentrations are increasingly changing to ethnobotanical practices due to availability at lower price, wide safety and efficacy margin and less side effects of plants. The medicinal benefits of the special phytochemical of the plants cannot be ignored. Some of the herbal plants have been expressed for their significance to take care of the different ailments of mankind particularly correlated to liver, GIT, stomach and colon.

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“…The free radical scavenging capacity of the extracts was accomplished using DPPH i.e. 1-diphenyl-2picrylhydrazyl on stable radical 1 [95][96][97] . In this, extract was dissolved in methanol and mixed with serial dilutions (1 to 500 µg) of Dillenia indica f. elongata (Miq.)…”

Section: Antioxidant Activitymentioning

confidence: 99%

A Review Update on Dillenia Indica F.ELONGATA (Miq.)miq.

Boparai

Niazi

Bajwa

et al. 2016

J. Drug Delivery Ther.

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Dillenia indica f. elongata (Miq.) Miq. (Dilleniaceae) commonly known as Elephant apple. The vernacular names include Chalta, Chulta, Karambel, Bhavya and Ramphal.It is found in Bangladesh, Nepal, China, Indonesia and Assam, West Bengal, Orissa, Bihar, Myanmar regions of India. Dillenia indica f. elongata (Miq.) Miq.has been prevalently used in Indian traditional and ayurvedic medicine for curing plethora of ailments such as digestive, respiratory and central nervous systems. The information was put together, with the help of literature surveyed. Traditionally different parts of Dillenia indica f. elongata (Miq.) Miq. have been used for the relief of indigestion, asthma, influenza, dysentery, jaundice, promeho, weakness and rheumatic pain. Moreover, the extractives showed significant cytotoxic, CNS depressant and free radical scavenging activity. Wood obtained from the bark of the plant has been used for preparing rafters, tool-handles, cupboard and house pots. It is interesting to know that bark of Dillenia indica f. elongata (Miq.) Miq.is used for production of charcoal. Microspheres of metformin hydrochloride and novel mucoadhesive buccal tablets of oxytocin were also prepared from Dillenia indica f. elongata (Miq.) Miq. In vitro propagation is practised whereas micropropagation is considered at the time, when large scale plant multiplication is required. Phytochemical studies revealed substantial presence of polyphenols, tannins, alkaloids and flavanoids which are responsible for the various pharmacological activities. Major chemical constituents present in the plant are betulin (pentacyclic triterpenoid) and betulinic acid that show wide spectrum of pharmacological activities which include anti-HIV, anti-inflammatory, anti-cancer, anti-malarial etc. Furthermore, Dillenia indica f. elongata (Miq.) Miq. is found to possess analgesic, anti-diabetic, anti-microbial,anti-bacterial,anti-diabetic,antioxidant,anti-proliferation,anti-diarrhoeal, antiimplantation, cytotoxic, wound healing and hair waving activity.

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Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena

Cited by 28 publications

References 12 publications

Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk-e- Saghir, A Traditional Preparation, and Its Ingredients

Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk-e- Saghir, A Traditional Preparation, and Its Ingredients

Phytochemical and Antioxidant Screening of Cassia Angustifolia,curcuma Zedoaria, Embelia Ribes, Piper Nigrum, Rosa Damascena,terminalia Belerica, Terminalia Chebula, Zingiber Officinale and Their Effect on Stomach and Liver

A Review Update on Dillenia Indica F.ELONGATA (Miq.)miq.

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