Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.

Gao, Tingting; Ma, Shuai; Song, Jiayin; Bi, Haibo; Tao, Yanduo

doi:10.1016/j.ijbiomac.2011.06.017

Cited by 31 publications

(17 citation statements)

References 38 publications

(37 reference statements)

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“…Dextrans D10 and D147 presented with a scavenging capacity of ~40%, while D40 showed a scavenging capacity of 50% (Figure 2G). This result was bigger than that obtained with 140 kDa glucans extracted from the roots of Aconitum kusnezoffii Reichb, which presented with a 33% capacity [18], as well as two glucans of 5 and 15 kDa obtained from the Ganoderma lucidum fungi that showed a scavenging capacity of around 30% [42]. However, we highlight the fact that, just as for the lipid peroxidation assay, the D40 dextran was more effective than the D10 and D147, which shows the main inhibition mechanism for lipid peroxidation in dextrans is in their capacity to scavenge the hydrogen peroxide.…”

Section: Resultsmentioning

confidence: 81%

“…With regards to other glucans, despite few records, it was verified that the activity occurs and that it is detached from the molecular weight, since α-glucans of 9 and 113 kDa extracted from Aconitum kusnezoffii Reichb tubers presented with a similar chelating activity for iron ions. However, it is noteworthy that the activity was only 10% [18]. Low chelating activity of iron was also identified in 5 and 15 kDa dextrans extracted from the Ganoderma lucidum mushroom fruiting body.…”

Section: Resultsmentioning

confidence: 99%

“…As an example, one can cite the α-glucans known as glycogen (a source of energy for animals) [14] and starch (α-glucan used as a source of energy by plants) [15]. However, α-glucans can also present with other interesting properties such as anti-inflammatory, antimicrobial [16], immunomodulatory [17] and antioxidant [18]. Not all α-glucans, however, have been extensively evaluated for their pharmacological potential.…”

Section: Introductionmentioning

confidence: 99%

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Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Soeiro

Melo

Alves

et al. 2016

IJMS

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Dextrans (α-d-glucans) extracted from Leuconostoc mesenteroides, with molecular weights (MW) of 10 (D10), 40 (D40) and 147 (D147) kDa, were evaluated as antioxidant, anticoagulant and immunomodulatory drugs for the first time. None presented anticoagulant activity. As for the antioxidant and immunomodulatory tests, a specific test showed an increase in the dextran activity that was proportional to the increase in molecular weight. In a different assay, however, activity decreased or showed no correlation to the MW. As an example, the reducing power assay showed that D147 was twice as potent as other dextrans. On the other hand, all three samples showed similar activity (50%) when it came to scavenging the OH radical, whereas only the D10 sample showed sharp activity (50%) when it came to scavenging the superoxide ion. D40 was the single dextran that presented with immunomodulatory features since it stimulated the proliferation (~50%) of murine macrophages (RAW 264.7) and decreased the release of nitric oxide (~40%) by the cells, both in the absence and presence of lipopolysaccharides (LPS). In addition, D40 showed a greater scavenging activity (50%) for the hydrogen peroxide, which caused it to also be the more potent dextran when it came to inhibiting lipid peroxidation (70%). These points toward dextrans with a 40 kDa weight as being ideal for antioxidant and immunomodulatory use. However, future studies with the D40 and other similarly 40 kDa dextrans are underway to confirm this hypothesis.

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Section: Resultsmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Soeiro

Melo

Alves

et al. 2016

IJMS

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“…However, some of them have been found to cause damage to liver [2]. In view of this, there has been an increasing interest in replacing the synthetic antioxidants with natural antioxidants in food, pharmaceutical and cosmetic industries [3,4].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey

Zhang

Pan

et al. 2012

International Journal of Biological Macromolecules

105

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“…[11]. Modern pharmacological studies have demonstrated that medicinal Aconitum plants can exert anti-inflammatory, analgesic [12,13], anti-arrhythmia [14], antioxidant [15], antibacterial [16], and anticancer effects [7,17]. In anticancer therapy, Aconitum plants have been proven effective for several types of cancer, such as lung, stomach, and liver cancers [18,19,20].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activities of C18-, C19-, C20-, and Bis-Diterpenoid Alkaloids Derived from Genus Aconitum

Ren

Shi

et al. 2017

Molecules

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Cancer is one of the most common lethal diseases, and natural products have been extensively studied as anticancer agents considering their availability, low toxicity, and economic affordability. Plants belonging to the genus Aconitum have been widely used medically in many Asian countries since ancient times. These plants have been proven effective for treating several types of cancer, such as lung, stomach, and liver cancers. The main effective components of Aconitum plants are diterpenoid alkaloids—which are divided into C18-, C19-, C20-, and bis-diterpenoid alkaloids—are reportedly some of the most promising, naturally abundant compounds for treating cancer. This review focuses on the progress of diterpenoid alkaloids with different structures derived from Aconitum plants and some of their derivatives with potential anticancer activities. We hope that this work can serve as a reference for further developing Aconitum diterpenoid alkaloids as anticancer agents.

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Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.

Cited by 31 publications

References 38 publications

Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey

Anticancer Activities of C18-, C19-, C20-, and Bis-Diterpenoid Alkaloids Derived from Genus Aconitum

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