Antioxidant and Moisturizing Properties of Carboxymethyl Chitosan with Different Molecular Weights

Abstract

<jats:p>This research aimed to synthesize carboxymethyl chitosan (CMCH) from different molecular weights of chitosan including low MW (L, 50–190 kDa), medium MW (M, 210–300 kDa) and high MW (H, 310–375 kDa) on the antioxidant and moisturizing properties. The L-CMCH, M-CMCH and H-CMCH improved the water solubility by about 96%, 90% and 89%, respectively when compared to native chitosan. Higher MW resulted in more viscous of CMCH. For antioxidant properties, IC50 values of DPPH and ABTS radical scavenging activity for L-CMCH were 1.70 and 1.37 mg/mL, respectively. The L-CMCH had higher antioxidant properties by DPPH and ABTS radical scavenging assay and FRAP. The moisturizing properties on pig skin using a Corneometer® showed that 0.5% H-CMCH significantly presented (p ≤ 0.05) greater moisturizing effect than that of untreated-skin, distilled water, propylene glycol and pure chitosan from three molecular weights.</jats:p>

Characterization of Chitosan Film Incorporated with Curcumin Extract

“…The FTIR spectra of chitosan films ( Figure 7 a) and the infrared spectra of chitosan incorporated with 0.16 mg/mL of curcumin extract ( Figure 7 b) should be obtained at peaks between 3500 and 3000 cm −1 . The characteristic peaks of chitosan are at 3455 cm −1 (O–H stretching), 2867 cm −1 (C–H stretching) [ 29 , 30 ], 1647 cm −1 (N–H bending), 1319 cm −1 (C–N stretching or amide II) [ 31 , 32 ], and 1023 cm −1 (C–O stretching) [ 17 , 33 ]. This shows that the stretching vibration of free hydroxyl and the symmetric stretching of the N–H bonds (amide A) [ 34 ] in an amino group are stronger in the control films when compared to the chitosan incorporated with curcumin extract [ 30 ].…”

“…The total radical scavenging capacity of curcumin extract was determined by using the DPPH with a modified method of Chaiwong et al [ 17 ].…”

Structural Characterization and Antioxidant Potential of Chitosan by γ-Irradiation from the Carapace of Horseshoe Crab

“…When thermal manifestation (50 to 650 °C) was applied to chitosan after γ-irradiation, it was discovered that degradation and decomposition occurred first, before the residue remained ( Figure 4 ). In this sense, heating chitosan at 100 °C causes water evaporation and proceeds with endothermic dehydration [ 41 ].…”

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

“…Interestingly, chitosan oligosaccharide recovered aging-induced liver dysfunction via the upregulation of Nrf2 antioxidant signaling [ 202 ]. Chitosan-gallic acid, synthetic carboxymethyl chitosan, chitosan-ellagic acid and selenide chitosan sulfate have also been demonstrated to have an antioxidant activity [ 203 , 204 , 205 , 206 ].…”