Antioxidant and osteogenic properties of anodically oxidized titanium

Iwai-Yoshida, Misato; Shibata, Yo; Wurihan,; Suzuki, Daisuke; Fujisawa, Naoki; Tanimoto, Yasuhiro; Kamijo, Ryutaro; Maki, Koutaro; Miyazaki, Takashi

doi:10.1016/j.jmbbm.2012.01.016

Cited by 26 publications

(19 citation statements)

References 18 publications

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“…Calcium phosphate coatings on Ti surfaces help increase its bioactivity and osteointegration (Kulkarni Aranya et al, ; Lee et al, ). However, complications, such as post‐implant fractures due to stress shielding, aseptic loosening (Jokstad, ; MacInnes, Gordon, & Wilkinson, ), poor long‐term stability, absence of antioxidant effects (Iwai‐Yoshida et al, ) and prolonged healing, remain as critical issues. To improve outcomes of fracture repairs using Ti implants, HA coatings have been attempted (Jones, Saigusa, Sickels, Tiner, & Gardner, ; Teraoka et al, ).…”

Section: Introductionmentioning

confidence: 99%

Silicon nitride enhances osteoprogenitor cell growth and differentiation via increased surface energy and formation of amide and nanocrystalline HA for craniofacial reconstruction

et al. 2019

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The bioactive silicon nitride (Si3N4) has been FDA cleared for use as spinal intervertebral arthrodesis devices. Because its surface properties promote bone ongrowth and ingrowth, it also has the potential to benefit craniofacial reconstruction. Thus, the aim of this work was to determine whether the surface properties of Si3N4 could enhance the osteoblast cell growth, differentiation and nucleation of hydroxyapatite (HA) crystals compared to conventional implant materials such as titanium (Ti) and polyether ether ketone (PEEK). X‐ray absorbance near‐edge structure analysis (XANES) indicated the presence of Si‐Si, Si‐O and Si‐N bonding. Surface wettability studies confirmed that Si3N4 exhibits the lowest contact angle and highest surface energy. Cell culture studies showed that osteoblast growth was enhanced on Si3N4 after 1 day and up to 7 days. Si3N4 surface induced highest surface coverage and thickness of nanocrystalline HA (211) and (203) in cell‐free in vitro studies after 7 days of culture. Raman spectroscopy analysis confirmed the presence of surface functional groups consisting of phosphate and carbonate species. Interestingly, Si3N4 surface showed amide and hydroxyproline groups, the precursors to collagen, which were not observed on Ti and PEEK surfaces. Furthermore, Si3N4 surface indicated high expression of RUNX2, enhanced cell differentiation and dense collagenous ECM after 30 days of the in vitro study. The present study concluded that Si3N4 surface enhances osteoprogenitor cell adhesion, growth, RUNX2 expression and ECM formation via the coupled effects of higher surface energy and the presence of amide and nanocrystalline HA functional groups.

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Section: Introductionmentioning

confidence: 99%

Silicon nitride enhances osteoprogenitor cell growth and differentiation via increased surface energy and formation of amide and nanocrystalline HA for craniofacial reconstruction

et al. 2019

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“…[13] Metal implants (e.g., titanium [Ti]) are used as structural materials because of their strength, however, they have long healing times, do not resorb, and have not shown any antioxidant effect. [14] Previous attempts to coat the metal implants with bioglass show that ionic products like Si +4 from the dissolution of bioglass enhance osteogenic markers expression and provide high production of collagen by osteoblast cells. [15,16] Similarly, strontium-doped bioactive glass coatings onto metal implants showed an improved anti-oxidative defense against ROS [4] yet, bioactive glass coatings lack interfacial adhesion and face delamination issues due to thermal expansion mismatch.…”

Section: Introductionmentioning

confidence: 99%

Amorphous Silica: A New Antioxidant Role for Rapid Critical‐Sized Bone Defect Healing

Ilyas

Odatsu

Shah

et al. 2016

Adv Healthcare Materials

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Traumatic fractures cause structurally unstable sites due to severe bone loss. Such fractures generate a high yield of reactive oxygen species (ROS) that can lead to oxidative stress. Excessive and prolonged ROS activity impedes osteoblast differentiation and instigates long healing times. Stimulation of antioxidants such as superoxide dismutase (SOD1), are crucial to reduce ROS, stimulate osteogenesis, and strengthen collagen and mineral formation. Yet, no current fixative devices have shown an ability to enhance collagen matrix formation through antioxidant expression. This study reports plasma-enhanced chemical vapor deposition based amorphous silicon oxynitride (Si(ON)x) as a potential new fracture healing biomaterial that adheres well to the implant surface, releases Si(+4) to enhance osteogenesis, and forms a surface hydroxyapatite for collagen mineral attachment. These materials provide a sustained release of Si(+4) in physiological environment for extended times. The dissolution rate partially depends on the film chemistry and can be controlled by varying O/N ratio. The presence of Si(+4) enhances SOD1, which stimulates other osteogenic markers downstream and leads to rapid mineral formation. In vivo testing using a rat critical-sized calvarial defect model shows a more rapid bone-regeneration for these biomaterials as compared to control groups, that implies the clinical significance of the presented biomaterial.

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“…e wettability is an important factor for cell adhesion, and its importance is almost the same as that of surface topography [33]. e existence of ROS and nanostructures might contribute to the better wettability of the fresh titanium surface [10,32,34]. After exposure to air for 7 days, the EA sample showed better wettability than the others.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Combined Micron‐Scale Surface and Different Nanoscale Features on Cell Response

Kang

Ren

Yuan

et al. 2018

Advances in Materials Science and Engineering

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Sandblasting and acid-etching (SLA) and anodization are the two most commonly used methods for surface modification of biomedical titanium. However, there are unavoidable problems such as residual sand particles and lack of hydrophilicity on the surface of titanium sheets treated with SLA technology. In addition, titanium implants showed only the micro/submicroscopic structure. In order to avoid the residue of sand particles in the surface of titanium, the two surface treatments etching treatment (E) and etched-anodizing (EA) on titanium were used, and their surface topography, surface chemistry, and surface roughness were compared with those of the SLA control group. eir wettability and the biocompatibility were also compared and evaluated. e results show that both E and EA samples have the micro/nano hierarchical structure and better wettability compared with the SLA samples. eir performances, especially the E surfaces, were enhanced in terms of cell adhesion, spreading, proliferation, and differentiation abilities.

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Antioxidant and osteogenic properties of anodically oxidized titanium

Cited by 26 publications

References 18 publications

Silicon nitride enhances osteoprogenitor cell growth and differentiation via increased surface energy and formation of amide and nanocrystalline HA for craniofacial reconstruction

Silicon nitride enhances osteoprogenitor cell growth and differentiation via increased surface energy and formation of amide and nanocrystalline HA for craniofacial reconstruction

Amorphous Silica: A New Antioxidant Role for Rapid Critical‐Sized Bone Defect Healing

The Effects of Combined Micron‐Scale Surface and Different Nanoscale Features on Cell Response

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