Antioxidant and physicochemical properties of acid degraded glucomannan

Wardhani, Dyah Hesti; Wardana, Irsyadia Nindya; Tajuddin, C A; Abdillah, Muhammad Aniq

doi:10.1063/1.5140937

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Porang is considered to have disease resistance, high coefficient of propagation, and adequate glucomannan content. GM reportedly have promising biopharmaceutical benefits and been widely used in pharmaceutical, chemical, and food technology industries (Wardhani et al, 2020). In some cases, degraded glucomannan proved to have better bioactivity, including its antioxidant activity and immunomodulatory function (Wardhani et al, 2020;Suzuki et al, 2010;Onishi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…GM reportedly have promising biopharmaceutical benefits and been widely used in pharmaceutical, chemical, and food technology industries (Wardhani et al, 2020). In some cases, degraded glucomannan proved to have better bioactivity, including its antioxidant activity and immunomodulatory function (Wardhani et al, 2020;Suzuki et al, 2010;Onishi et al, 2005). However, most of these studies used glucomannan from konjac, while research on porang glucomannan was still limited.…”

Section: Introductionmentioning

confidence: 99%

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Glucohealth: The potential of porang (Amorphophallus muelleri) acid hydrolysed glucomannan as an inhibitor of SARS-CoV-2 interaction with ACE2

Ulayya

Mubarok

Widodo

et al. 2021

AFSSAAE

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The novel SARS-CoV-2 that causing global pandemic COVID-19 known to enter the host cell using the hACE2 as cell receptor. SARS-CoV S1 protein cleaves the ACE2 receptor, then the S2 subunits facilitates the cell membrane fusion, the inhibition of S1-ACE2 interaction can help develop anti SARS-CoV-2 medication. Porang glucomannan is a polysaccharide known as immunomodulator but never reported as anti-virus by direct inhibition of viral entry. Glucohealth was developed to investigate its potential. Method: Glucohealth is a glucomannan hydrolysate (HGM) that made from porang (Amorphophallus muelleri). Hydrolysis was carried using HCl in different concentration (0.25N, 0.5N, 1N) then analyzed its inhibitor activity using ELISA kit. Result: Higher HCl concentration produced HGM with smaller average particle size and lower glucomannan content. However, ELISA studies showed that glucomannan, including its hydrolysates, have the potency to bind with S1 protein and inhibit the binding activity of S1-ACE2. Degraded glucomannan proven to have better bioactivity and able to interact with pathogen to inhibit its cell entry. This project should be a gateway for further biomedical study of glucomannan from Indonesia’s local tuber and new approach to produce more natural therapy against COVID-19.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Glucohealth: The potential of porang (Amorphophallus muelleri) acid hydrolysed glucomannan as an inhibitor of SARS-CoV-2 interaction with ACE2

Ulayya

Mubarok

Widodo

et al. 2021

AFSSAAE

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Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids

Shi

Yin

Cui

et al. 2020

International Journal of Biological Macromolecules

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Physicochemical and Rheological Properties of Degraded Konjac Gum by Abalone (Haliotis discus hannai) Viscera Enzyme

Lin,

Wen,

Lin

et al. 2024

Foods

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In the present study, a new degraded konjac glucomannan (DKGM) was prepared using a crude enzyme from abalone (Haliotis discus hannai) viscera, and its physicochemical properties were investigated. After enzymatic hydrolysis, the viscosity of KGM obviously decreased from 15,500 mPa·s to 398 mPa·s. The rheological properties analysis of KGM and DKGMs revealed that they were pseudoplastic fluids, and pseudoplasticity, viscoelasticity, melting temperature, and gelling temperature significantly decreased after enzymatic hydrolysis, especially for KGM-180 and KGM-240. In addition, the molecular weight of KGM decreased from 1.80 × 106 Da, to 0.45 × 106 Da and the polydispersity index increased from 1.17 to 1.83 after 240 min of degradation time. Compared with natural KGM, the smaller particle size distribution of DKGM further suggests enzyme hydrolysis reduces the aggregation of molecular chains with low molecular weight. FT-IR and FESEM analyses showed that the fragmented KMG chain did not affect the structural characteristics of molecular monomers; however, the dense three-dimensional network microstructure formed by intermolecular interaction changed to fragment microstructure after enzyme hydrolysis. These results revealed that the viscosity and rheological properties of KGM could be controlled and effectively changed using crude enzymes from abalone viscera. This work provides theoretical guidance for the promising application of DKGM in the food industry.

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Antioxidant and physicochemical properties of acid degraded glucomannan

Cited by 3 publications

References 23 publications

Glucohealth: The potential of porang (Amorphophallus muelleri) acid hydrolysed glucomannan as an inhibitor of SARS-CoV-2 interaction with ACE2

Glucohealth: The potential of porang (Amorphophallus muelleri) acid hydrolysed glucomannan as an inhibitor of SARS-CoV-2 interaction with ACE2

Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids

Physicochemical and Rheological Properties of Degraded Konjac Gum by Abalone (Haliotis discus hannai) Viscera Enzyme

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