Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids

Shi, Xiaodan; Yin, Jingdong; Cui, Steve W.; Qi, Wang; Wang, Shaoyun; Nie, Shaoping

doi:10.1016/j.ijbiomac.2020.07.186

Cited by 17 publications

(9 citation statements)

References 51 publications

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“…Likewise, the combination of D. officinale and other Chinese herbal medicine, such as Acanthopanax senticosus, Panaxnotoginseng, Didymocarpus hancei and Valeriana officinalis can also alleviate gastric mucosal injury (Guo, 2020b). The 14-days treatment of D. officinale glucomannans at 0.16 g/kg produced more SCFAs (mainly acetate and butyrate) in cecum and colon (Shi et al, 2020). It should be noted that polysaccharides LDOP-1 isolated from D. officinale could protect ethanol-induced gastric mucosal injury in vitro (250, 125, and 62.5 mg/ml for 2 h) and in vivo (100 and a very high dose of 400 mg/kg for 30 days) by regulating AMP-activated protein kinase (AMPK)/mTOR signaling pathway demonstrated by the increased levels of p-AMPK, light chain 3β (LC-3β), heme oxygenase-1 (HO-1) and Beclin-1, the decreased levels of p-mTOR and p62, and the reversed levels of caspase3, Bax, and Bcl-2 detected both in vitro and in vivo (Ke et al, 2020).…”

Section: Gastrointestinal Protective Effectmentioning

confidence: 96%

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Wen-hua

Zhang

et al. 2021

Front. Pharmacol.

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Dendrobium officinale, a well-known plant used as a medicinal and food homologous product, has been reported to contain various bioactive components, such as polysaccharides, bibenzyls, phenanthrenes, and flavonoids. It is also widely used as a traditional medicine to strengthen “Yin”, nourish heart, tonify five viscera, remove arthralgia, relieve fatigue, thicken stomach, lighten body, and prolong life span. These traditional applications are in consistent with modern pharmacological studies, which have demonstrated that D. officinale exhibits various biological functions, such as cardioprotective, anti-tumor, gastrointestinal protective, anti-diabetes, immunomodulatory, anti-aging, and anti-osteoporosis effects. In this review, we summarize the research progress of D. officinale from November 2016 to May 2021 and aim to better understand the botany, traditional use, phytochemistry, and pharmacology of D. officinale, as well as its quality control and safety. This work presents the development status of D. officinale, analyzes gaps in the current research on D. officinale, and raises the corresponding solutions to provide references and potential directions for further studies of D. officinale.

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Section: Gastrointestinal Protective Effectmentioning

confidence: 96%

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Wen-hua

Zhang

et al. 2021

Front. Pharmacol.

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“…to create these feelings of satiety, including fenugreek galactomannan (Mathern, Raatz, Thomas, & Slavin, 2009), fructooligosaccharide (Cani et al, 2009), konjac, and of course acemannan (Shi et al, 2020).…”

Section: Digestion and Diabetes: Acemannan As A Soluble Dietary Fibrementioning

confidence: 99%

“…The type of oligosaccharide and the microbial community of the host influences the flux and load of short-chain fatty acids (Shi et al, 2020), but the major product is acetic acid, followed by glucose and cholesterol control (Alexander, Swanson, Fahey, & Garleb, 2019). Most of these effects are not restricted to acemannan; they are known to be outcomes from ingestion and digestion of nonstarch polysaccharides (soluble fibres) in general.…”

Section: Digestion and Diabetes: Acemannan As A Soluble Dietary Fibrementioning

confidence: 99%

“…Orally ingested fibres such as acemannan confer prebiotic effects and are metabolised into short‐chain fatty acids (Sarbini & Rastall, 2011). The type of oligosaccharide and the microbial community of the host influences the flux and load of short‐chain fatty acids (Shi et al, 2020), but the major product is acetic acid, followed by propanoic and butyric acids (den Besten et al, 2013). Short‐chain fatty acids are an energy source for colonocytes or enterocytes, but also enact many apparently good biological effects in the body.…”

Section: Oral Acemannan or A Vera Gelmentioning

confidence: 99%

“…The most important effector is an acetic acid salt, which alters the expression of γ‐aminobutyric acid and increases anorectic neuropeptide, bringing about a greater sensation of “fullness” from a meal (Sampson & Mazmanian, 2015). In this regard, many soluble fibres have been used to create these feelings of satiety, including fenugreek galactomannan (Mathern, Raatz, Thomas, & Slavin, 2009), fructooligosaccharide (Cani et al, 2009), konjac, and of course acemannan (Shi et al, 2020).…”

Section: Oral Acemannan or A Vera Gelmentioning

confidence: 99%

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Pharmacodynamics of Aloe vera and acemannan in therapeutic applications for skin, digestion, and immunomodulation

Sadgrove

Simmonds

2021

Phytotherapy Research

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Scientific studies of Aloe vera have tentatively explained therapeutic claims from a mechanistic perspective. Furthermore, in vitro outcomes demonstrate that the breakage of acemannan chains into smaller fragments enhances biological effects. These fragments can intravenously boost vaccine efficacy or entrain the immune system to attack cancer cells by mannose receptor agonism of macrophage or dendritic cells. With oral consumption, epithelialisation also occurs at injured sites in the small intestine or colon. The main advantage of dietary acemannan is the attenuation of the digestive process, increasing satiety, and slowing the release of sugars from starches. In the colon, acemannan is digested by microbes into short‐chain fatty acids that are absorbed and augment the sensation of satiety and confer a host of other health benefits. In topical applications, an acemannan/chitosan combination accelerates the closure of wounds by promoting granular tissue formation, which creates a barrier between macrophages or neutrophils and the wound dressing. This causes M2 polarisation, reversal of inflammation, and acceleration of the re‐epithelialisation process. This review summarises and explains the current pharmacodynamic paradigm in the context of acemannan in topical, oral, and intravenous applications. However, due to contradictory results in the literature, further research is required to provide scientific evidence to confirm or nullify these claims.

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Recent progress in biological activities and health benefits of konjac glucomannan and its derivatives

Liu

Ding

2021

Bioactive Carbohydrates and Dietary Fibre

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Comparative study on glucomannans with different structural characteristics: Functional properties and intestinal production of short chain fatty acids

Cited by 17 publications

References 51 publications

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Pharmacodynamics of Aloe vera and acemannan in therapeutic applications for skin, digestion, and immunomodulation

Recent progress in biological activities and health benefits of konjac glucomannan and its derivatives

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