Antioxidant and pro‐oxidant capacities of ITCs

Valgimigli, Luca; Iori, Renato

doi:10.1002/em.20468

Cited by 91 publications

(64 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is believed that the major mode of action of sulforaphane in mammalian cells is to decrease the cellular glutathione pool (Valgimigli and Iori, 2009). This would be consistent with its reactive electrophile properties, and it is well known that plant defense triggers oxidative stress that contributes to cell death (Overmyer et al, 2003;Torres, 2010).…”

Section: Sulforaphane and Other Isothiocyanates Induce Cell Death In mentioning

confidence: 99%

Involvement of the Electrophilic Isothiocyanate Sulforaphane in Arabidopsis Local Defense Responses

et al. 2014

View full text Add to dashboard Cite

Plants defend themselves against microbial pathogens through a range of highly sophisticated and integrated molecular systems. Recognition of pathogen-secreted effector proteins often triggers the hypersensitive response (HR), a complex multicellular defense reaction where programmed cell death of cells surrounding the primary site of infection is a prominent feature. Even though the HR was described almost a century ago, cell-to-cell factors acting at the local level generating the full defense reaction have remained obscure. In this study, we sought to identify diffusible molecules produced during the HR that could induce cell death in naive tissue. We found that 4-methylsulfinylbutyl isothiocyanate (sulforaphane) is released by Arabidopsis (Arabidopsis thaliana) leaf tissue undergoing the HR and that this compound induces cell death as well as primes defense in naive tissue. Two different mutants impaired in the pathogen-induced accumulation of sulforaphane displayed attenuated programmed cell death upon bacterial and oomycete effector recognition as well as decreased resistance to several isolates of the plant pathogen Hyaloperonospora arabidopsidis. Treatment with sulforaphane provided protection against a virulent H. arabidopsidis isolate. Glucosinolate breakdown products are recognized as antifeeding compounds toward insects and recently also as intracellular signaling and bacteriostatic molecules in Arabidopsis. The data presented here indicate that these compounds also trigger local defense responses in Arabidopsis tissue.

show abstract

Section: Sulforaphane and Other Isothiocyanates Induce Cell Death In mentioning

confidence: 99%

Involvement of the Electrophilic Isothiocyanate Sulforaphane in Arabidopsis Local Defense Responses

et al. 2014

View full text Add to dashboard Cite

show abstract

“…These indices show the high reactivity and low stability of the formed radicals of ITC compounds. This may allow explaining the prooxidant potential of ITCs as reported in literature [12].…”

Section: Ionization Energy (Ie) and Electron Affinity (Ea)mentioning

confidence: 62%

A Density Functional Theory Study of Antioxidant Activity of Isothiocyanates in Broccoli Sprouts (Brassica Oleracea L.)

Phan

2018

JST

View full text Add to dashboard Cite

Antioxidant activity of 9 isothiocyanate derivatives (−N=C=S) extracted from Broccoli sprouts (Brassica oleracea L.) has been investigated using density functional theory (DFT) -based computational methods. Through the hydrogen atom transfer (HAT) and single electron transfer (SET) mechanisms, three thermodynamic parameters including bond dissociation enthalpy (BDE), vertical ionization energy (IE), and vertical electron affinity (EA) were calculated in the gas phase using B3LYP/6-311++G(3df,3p)//B3LYP/6-311G(d,p) model chemistry. As a result, the isothiocyanate (ITC) shows potential antioxidant activity via HAT mechanism. The most potential antioxidant is 3-isothiocyanato pro-1-en (3ITCP) with BDE(C−H) of 72.9 kcal/mol. The SET mechanism is not dominant in case of the studied ITCs. Moreover, the radicals formed H• removal had more reactive and less stable than the intial neutral compounds with lower IE, higher EA and ω.

show abstract

“…Sinigrin, a glucosinolate compound in Brassica nigra L. (black mustard) is hydrolyzed to allylisothiocyanate by myrosinase enzyme present in the plant tissues. Allylisothiocyanate are able to modulate phase I enzymes, particularly cytochrome P450 (Valgimigli and Iori, 2009). Interestingly, the immunological effect of black mustard has not examined before neither on human nor animal.…”

Section: Introductionmentioning

confidence: 99%

Effect of Black Mustard (Brassica nigra) on the Interaction between Immune and Biotransformation Systems of Nile Tilapia (Oreochromis niloticus) Exposed to Benzo-a-Pyrene

Abbas¹,

Awad²,

Abdel-Rahm³

2015

J. of Fisheries and Aquatic Science

View full text Add to dashboard Cite

Aquatic pollutants are responsible form any alterations in fish health. Our study was designed to examine the efficacy of dietary supplement of black mustard seed, Brassica nigra (30% crude and 1% alcoholic extract) on enhancement the immunity and detoxification response of Nile tilapia, Oreochromis niloticus after exposed to a hydrocarbon pollutant; Benzo-a-Pyrene (BaP). Fish were divided into 3 groups before being fed for 28 days with crude black mustard seeds,1% alcoholic extract and un-supplemented commercial diet as the control. At the end of experiment, fish were exposed to 1 mg LG 1 of BaP for 24 h. Humoral immune parameters (lysozyme activity, antiprotease activity and total protein),ethoxyresorufin-o-deethylase (EROD) and hepatic cytochrome P450 1A1 content (CYP1A1) were investigated. Results recorded high significant difference (p<0.05) of antiprotease and total protein values in group fed with 1% extract followed by crude seeds as compared with control. The highest significant lysozyme activity (p<0.05) was recorded also in group fed with 1% extract as compared with other groups. On the other hand the extract group revealed a significant decrease in EROD (p<0.05) and CYP1A1 content compared to other groups. Which lowering the possible toxic effect of bio-transformed metabolic intermediate compounds.While the EROD activity and CYP1A1 content in group fed with the crude seeds showed increase over the control one. Therefore, the results suggest using of black mustard extract as a dietary supplement to increase the immune function and enhance the detoxification process of pollutants and hence, reduce the harmful effect of aquatic pollutants on Nile tilapia health.

show abstract

Antioxidant and pro‐oxidant capacities of ITCs

Cited by 91 publications

References 102 publications

Involvement of the Electrophilic Isothiocyanate Sulforaphane in Arabidopsis Local Defense Responses

Involvement of the Electrophilic Isothiocyanate Sulforaphane in Arabidopsis Local Defense Responses

A Density Functional Theory Study of Antioxidant Activity of Isothiocyanates in Broccoli Sprouts (Brassica Oleracea L.)

Effect of Black Mustard (Brassica nigra) on the Interaction between Immune and Biotransformation Systems of Nile Tilapia (Oreochromis niloticus) Exposed to Benzo-a-Pyrene

Contact Info

Product

Resources

About