Antioxidant and protective effects of Phytocee<sup>™</sup>against carbon tetrachloride-induced oxidative stress

Joseph, Joshua Allan; Radhakrishnan, Uma; Mutyala, Sridhar; Goudar, K.S.; Ayyappan, Usha Parackal Thachappully; Agarwal, Amit

doi:10.4103/0976-9668.149119

Cited by 5 publications

(4 citation statements)

References 27 publications

(29 reference statements)

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“…Higher levels of corticosterone lead to increase in oxidative stress, decrease in follicle numbers, induce cell death in follicular cells and subsequently reducing egg production [17]. Reference [9] reported that PGC had markedly reversed induced oxidative stress and can be used as an antioxidant feed supplement. The herbs present in the PGC are known to have antioxidant, antistress, adaptogenic, immunomodulatory properties.…”

Section: A Effect Of Pgc On Egg Production and Feed Intake Parametersmentioning

confidence: 99%

“…PGC contains active phytochemicals like polyphenols, withanolides and other triterpenoids. Some studies already showed that PGC is a natural defense enhancer which boosts endurance, optimizes cell mediated immunity as well as helps in reducing harmful effects of stress [9], [10]. In addition, these individual plant ingredients have shown antioxidant property, and as a whole many studies have shown the effectiveness of PGC in in vitro and invivo models combating stress [10], [11].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Phytogenic Feed Additive on Egg Production, Egg Quality and Feed Intake in Layer Chicken

Suresh

D’Souza²,

Marimuthu³

2023

EJVETMED

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The commercial layer production in chicken farms has usually been exposed to wide range of stress stimulants, which adversely affect the feed intake and body weight that in-turn depress the egg production and quality. Hence, it’s a major area of concern to reduce the stress and increase the production benefiting the farmer and health of the bird. The present study was designed to evaluate the impact of phytogenic feed additive (PGC) on egg production, egg quality and feed intake in layer chicken. A total of 320 birds of age 65 weeks of BV300 layers were randomly assigned to 2 groups (Control and PGC groups) with 10 replicates comprising 16 birds each (n = 160). The control group was provided with standard commercial feed as recommended by NRC specifications. In PGC group PhytoceeTM was supplemented at 200 g/ton with standard commercial feed. The study period was 6 weeks (65 weeks to 70 weeks) and data was collected on 7 days interval. The data on egg production, feed intake and egg quality parameters (egg weight and shell parameters) were collected during the study. The group fed with PGC had showed numerical improvement in egg production and decreased egg defects during the study period when compared to control group. The feed intake was not much altered in both the groups. The egg density, egg strength, shell weight, shell thickness and shell percentage were numerically improved in PGC supplemented group when compared with control. The supplementation of PGC had considerably improved the egg quality and production parameters in layer birds by helping them in reducing the harmful effects of stress.

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Section: A Effect Of Pgc On Egg Production and Feed Intake Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Phytogenic Feed Additive on Egg Production, Egg Quality and Feed Intake in Layer Chicken

Suresh

D’Souza²,

Marimuthu³

2023

EJVETMED

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“…An imbalance between the generation of ROS and cellular antioxidant capacity can lead to oxidative stress. [ 1 2 ] ROS are implicated in the etiology of several degenerative diseases such as stroke, rheumatoid arthritis, diabetes mellitus, peptic ulcer, and cancer. [ 3 4 ] Phytomedicine plays a very important role in the management of most of these diseases.…”

Section: Introductionmentioning

confidence: 99%

DNA damage protecting activity and antioxidant potential of Launaea taraxacifolia leaves extract

et al. 2018

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Background:The leaf extract of Launaea taraxacifolia commonly known as African Lettuce is used locally to treat dyslipidemia and liver diseases, which are associated with oxidative stress. Methanol extract from L. taraxacifolia leaves was tested for its antioxidant activity and its ability to protect DNA from oxidative damage.Materials and Methods:In vitro antioxidant potential of the leaf extract was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO), and hydroxyl (OH) radical scavenging assays. Ferric reducing power, total antioxidant capacity (TAC), metal chelating, and anti-lipid peroxidation ability of the extract were also examined using gallic acid, ascorbic acid, citric acid, and ethylenediaminetetraacetic acid as standards.Results:L. taraxacifolia leaves extract showed antioxidant activity with IC50 values of 16.18 μg/ml (DPPH), 123.3 μg/ml (NO), 128.2 μg/ml (OH radical), 97.94 μg/ml (metal chelating), 80.28 μg/ml (TAC), and 23 μg/ml (anti-lipid peroxidation activity). L. taraxacifolia leaves extract exhibited a strong capability for DNA damage protection at 20 mg/ml concentration.Conclusion:These findings suggest that the methanolic leaf extract of L. taraxacifolia could be used as a natural antioxidant and also as a preventive therapy against diseases such as arteriosclerosis associated with DNA damage.

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“…Even though proofs of efficacy on these PFS are available [ 5 , 6 ], it is vital to assess safety to support their long-term use. Hence, the current study evaluated the PFS for their possible toxic potential by using in vitro BRMT and in vivo acute oral toxicity test.…”

Section: Introductionmentioning

confidence: 99%

Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements

Rao

Chandrasekaran

Srikanth

et al. 2018

Journal of Toxicology

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Herbal products are being used and trusted globally for thousands of years for their health benefits and limited side effects. Globally, a general belief amongst the consumers is that herbal supplements are always safe because they are “natural.” But later, research reveals that they may not be safe. This raises concern on their safety and implications for their use as feed supplement or medicine. Toxicity testing can reveal some of the risks that may be associated with use of herbs, therefore avoiding potential harmful effects. The present study was designed to investigate five poultry feed supplements (PFS), EGMAX® (to revitalize ovarian activity), FEED-X™ (feed efficiency enhancer), KOLIN PLUS™ (natural replacer of synthetic choline chloride), PHYTOCEE® (natural defence enhancer), and STODI® (to prevent and control loose droppings), for their possible mutagenicity and toxicity. Bacterial reverse mutation (BRMT) and acute oral toxicity tests were employed to assess the PFS for their possible mutagenicity and toxicity. Results indicated that the PFS were devoid of mutagenic effects in BRMT and showed higher safety profile in rodent acute oral toxicity test.

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Antioxidant and protective effects of Phytocee^™against carbon tetrachloride-induced oxidative stress

Cited by 5 publications

References 27 publications

Evaluation of Phytogenic Feed Additive on Egg Production, Egg Quality and Feed Intake in Layer Chicken

Evaluation of Phytogenic Feed Additive on Egg Production, Egg Quality and Feed Intake in Layer Chicken

DNA damage protecting activity and antioxidant potential of Launaea taraxacifolia leaves extract

Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements

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Antioxidant and protective effects of Phytocee™against carbon tetrachloride-induced oxidative stress

Cited by 5 publications

References 27 publications

Evaluation of Phytogenic Feed Additive on Egg Production, Egg Quality and Feed Intake in Layer Chicken

Evaluation of Phytogenic Feed Additive on Egg Production, Egg Quality and Feed Intake in Layer Chicken

DNA damage protecting activity and antioxidant potential of Launaea taraxacifolia leaves extract

Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements

Contact Info

Product

Resources

About

Antioxidant and protective effects of Phytocee^™against carbon tetrachloride-induced oxidative stress