Antioxidant, Anti-Inflammation and Antiaging Activities of Artocarpus altilis Methanolic Extract on Urban Particulate Matter-Induced HaCaT Keratinocytes Damage

Abstract

Particulate matter (PM) is one of the reasons that exacerbate skin diseases. Impaired barrier function is a common symptom in skin diseases, including atopic dermatitis, eczema and psoriasis. Herbal extracts rich in antioxidants are thought to provide excellent pharmacological activities; however, the anti-pollution activity of Artocarpus altilis extract (AAM) has not been investigated yet. The present study demonstrated that 5 μg/mL of AAM was considered to be a safe dose for further experiments without cytotoxicity. Next, we evaluated the anti-pollution activity of AAM through the PM-induced keratinocytes damage cell model. The results showed that AAM could reduce PM-induced overproduction of intracellular ROS and the final product of lipid peroxidation, 4-hydroxynonenal (4HNE). In addition, AAM not only reduced the inflammatory protein expressions, including tumor necrosis factor α (TNFα), TNF receptor 1 (TNFR1) and cyclooxygenase-2 (COX-2), but also balanced the aging protein ratio of matrix metalloproteinase (MMPs) and tissue inhibitors of metalloproteases (TIMPs) through downregulating the phosphorylation of mitogen-activated protein kinase (MAPK) signaling. For skin barrier protection, AAM could repair PM-induced barrier function proteins damage, including filaggrin, loricrin and aquaporin 3 for providing anti-aging bioactivity. In conclusion, AAM has the potential to be developed as an anti-pollution active ingredient for topical skin products to prevent skin oxidation, inflammation and aging, and restore the skin barrier function.

Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte

“…Oxidative stress and skin inflammation are one of the damages that the skin disease 16 . Mechanisms of inflammation and oxidative stress in skin diseases have already been identified 17 , 18 . However, it was unknown whether Lonicera japonica & Chenpi distillation extract (LCDE) treatment affects pro-inflammatory cytokines associated with the progression of skin damage in HaCaT cells 11 and which selected compounds have the extent of antioxidant effect.…”

Polyphenols in edible plant leaves: an overview of their occurrence and health properties

“…45,46 The production of leaf-based beverages involves several manufacturing processes that can influence the phenolic composition of the beverages, including the extraction method, fermentation, drying, or even roasting of the leaves. [47][48][49] In this review, only non-alcoholic beverages obtained by aqueous extraction will be examined, as they represent the majority of leaf-based beverages consumed worldwide. Beverages obtained by infusion or decoction enjoy a status as important sources of polyphenol intake in diets worldwide.…”

Evaluation of Anti-aging Effects of Gemfibrozil on D-galactose induced Aging Mouse Model

“…17 Many researchers have investigated the role of many drugs and herbs in alleviating age-related changes utilizing their antioxidant anti-inflammatory activity. 18,19 Gemfibrozil has been reported to control biological pathways independent of PPAR-α. Including anti-inflammatory and ant oxidative mechanisms of which l is believed to occur via PPAR-α-independent pathways.…”