Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease

Vincenzo, Angelo Di; Tana, Claudio; H, El Hadi; Pagano, Claudio; Vettor, Roberto; Rossato, Marco

doi:10.3390/ijms20205101

Cited by 62 publications

(48 citation statements)

References 56 publications

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“…Another study in Iran reported that dietary intake of vitamin E was associated with a decreased risk of incident CKD ( 21 ) . In human interventional studies, vitamin E supplementation decreased the risk of contrast-induced acute kidney injury in CKD patients and provided a positive effect on kidney function in diabetic patients ( 16 , 23 ) . On the other hand, there are some conflicting results on the association between vitamin E intake and kidney function ( 23 ) .…”

Section: Discussionmentioning

confidence: 99%

“…In human interventional studies, vitamin E supplementation decreased the risk of contrast-induced acute kidney injury in CKD patients and provided a positive effect on kidney function in diabetic patients ( 16 , 23 ) . On the other hand, there are some conflicting results on the association between vitamin E intake and kidney function ( 23 ) . In addition, a recent epidemiological study reported that there was no association between serum vitamin E concentration and eGFR decline in young US adults ( 24 ) .…”

Section: Discussionmentioning

confidence: 99%

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Gender difference in the association of dietary intake of antioxidant vitamins with kidney function in middle-aged and elderly Japanese

et al. 2021

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Dietary intake modification is important for the treatment of chronic kidney disease (CKD); however, little is known about the association between dietary intake of antioxidant vitamins and kidney function based on gender difference. We examined the relationship of dietary intake of antioxidant vitamins with decreased kidney function according to gender in Japanese subjects. This population-based, cross-sectional study included 936 Japanese participants with the age of 40 years or older. A validated brief self-administered diet history questionnaire was used to measure dietary intakes of vitamin E and its four isoforms, vitamin A and vitamin C. Decreased kidney function was defined as estimated glomerular filtration rate <60 ml/min/1·73 m2. A total of 498 (53·2 %) of the study participants were women. Mean age was 62·4 ± 11·3 years. Overall, 157 subjects met the criteria of decreased kidney function. In the fully adjusted model, a high vitamin E intake is inversely associated with decreased kidney function in women (odds ratio, 0·886; 95 % confidence interval, 0·786–0·998), whereas vitamin E intake was not associated with decreased kidney function (odds ratio, 0·931; 95 % confidence interval, 0·811–1·069) in men. No significant association between dietary intake of vitamins A and C and decreased kidney function was observed in women and men. Higher dietary intake of vitamin E was inversely associated with decreased kidney function in middle-aged and older women, and the result may provide insight into the more tailored dietary approaches to prevent CKD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gender difference in the association of dietary intake of antioxidant vitamins with kidney function in middle-aged and elderly Japanese

et al. 2021

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“…The overproduction of these end-products and by-products of these pathways results in microvascular and macrovascular complications of diabetes [ 2 ]. Specifically, NFκB activation and PKC activation lead to abnormal upregulation of vascular and endothelial activity in renal glomeruli in diabetes [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The role of vitamin E supplementation for metabolic diseases and diabetes-associated complications remains controversial. [ 3 ] The MICRO-HOPE study (2000) showed no significant renoprotective and cardioprotective outcomes with daily administration of tocopherol for 4.5 years [ 8 ]. A few systematic reviews concluded there was insufficient evidence to support the role of vitamin E as tocopherols for supplementation; there was no significant improvement in diabetic control as assessed by HbA1c levels and fasting sugar levels in the unselected population [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

A Phase IIb Randomized Controlled Trial Investigating the Effects of Tocotrienol-Rich Vitamin E on Diabetic Kidney Disease

et al. 2021

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Diabetic kidney disease (DKD) is a debilitating complication of diabetes, which develops in 40% of the diabetic population and is responsible for up to 50% of end-stage renal disease (ESRD). Tocotrienols have shown to be a potent antioxidant, anti-inflammatory, and antifibrotic agent in animal and clinical studies. This study evaluated the effects of 400 mg tocotrienol-rich vitamin E supplementation daily on 59 DKD patients over a 12-month period. Patients with stage 3 chronic kidney disease (CKD) or positive urine microalbuminuria (urine to albumin creatinine ratio; UACR > 20–200 mg/mmol) were recruited into a randomized, double-blind, placebo-controlled trial. Patients were randomized into either intervention group (n = 31) which received tocotrienol-rich vitamin E (Tocovid SupraBioTM; Hovid Berhad, Ipoh, Malaysia) 400 mg daily or a placebo group which received placebo capsules (n = 28) for 12 months. HbA1c, renal parameters (i.e., serum creatinine, eGFR, and UACR), and serum biomarkers were collected at intervals of two months. Tocovid supplementation significantly reduced serum creatinine levels (MD: −4.28 ± 14.92 vs. 9.18 ± 24.96), p = 0.029, and significantly improved eGFR (MD: 1.90 ± 5.76 vs. −3.29 ± 9.24), p = 0.011 after eight months. Subgroup analysis of 37 patients with stage 3 CKD demonstrated persistent renoprotective effects over 12 months; Tocovid improved eGFR (MD: 4.83 ± 6.78 vs. −1.45 ± 9.18), p = 0.022 and serum creatinine (MD: −7.85(20.75) vs. 0.84(26.03), p = 0.042) but not UACR. After six months post washout, there was no improvement in serum creatinine and eGFR. There were no significant changes in the serum biomarkers, TGF-β1 and VEGF-A. Our findings verified the results from the pilot phase study where tocotrienol-rich vitamin E supplementation at two and three months improved kidney function as assessed by serum creatinine and eGFR but not UACR.

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“…(Middleton et al, 2000;Pavlova, 2016). Antioxidants (AOs) of natural origin such as quercetin (Quer) (Ozgen et al, 2016;Xu et al, 2019), curcumin (Cur) (Liu et al, 2017;Rachmani et al, 2018), vitamin E (Di Vincenzo et al, 2019), and coenzyme Q 10 (Tiano et al, 2007;Liu et al, 2016) may be effective for treating these pathologies. The high lipophilicity of these compounds, however, impedes their use as injectable preparations.…”

Section: Introductionmentioning

confidence: 99%

Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease

Pylypenko¹,

Gorbach²,

Krasnopolsky³

2020

bta

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Quercetin and curcumin are plant polyphenolic antioxidants with proven pharmacological efficacy. Their use is, however, limited due to low bioavailability and oral administration route. The encapsulation of lipophilic compounds in liposomes enables to increase their bioavailability and to create an injectable form. The present study aimed to comparatively investigate the antioxidant activity of a complex liposomal preparation containing two lipophilic antioxidants (quercetin and curcumin) and their monopreparations in liposomal forms. This study was conducted on Wistar line rats with experimental model of ischemic heart disease. Oxidative stress markers such as total antioxidant activity, malondialdehyde, and peroxidized proteins were analyzed in blood serum and cardiac tissue. Ischemic heart disease is accompanied with lipid peroxidation and changes in the activity of the antioxidant system. The obtained results demonstrated the antioxidant activity of monopreparations of curcumin and quercetin and their complex in liposomal forms. Quercetin and curcumin showed different antioxidant activities in terms of oxidative stress markers. The complex of the two antioxidants showed the synergistic effect of their lipophilic compounds in liposomal forms, which led to the normalization of test parameters according to the level of the control sample.

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Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease

Cited by 62 publications

References 56 publications

Gender difference in the association of dietary intake of antioxidant vitamins with kidney function in middle-aged and elderly Japanese

Gender difference in the association of dietary intake of antioxidant vitamins with kidney function in middle-aged and elderly Japanese

A Phase IIb Randomized Controlled Trial Investigating the Effects of Tocotrienol-Rich Vitamin E on Diabetic Kidney Disease

Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease

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