Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease

Pylypenko, Daria; Gorbach, T. V.; Krasnopolsky, Yuriy

doi:10.5114/bta.2020.100420

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Quercetin can improve the antioxidant ability of the ovary by up-regulating the oxidative stress-related genes in rat. 37 In addition, Quercetin activates the nuclear factor Nrf2-ARE (erythroid-derived 2) like 2/ Antioxidant response element path and induces the activity of phase II anti-oxidant enzymes like glutathione stransferase, catalase, superoxide dismutase, NAD(P)H: quinone oxidoreductase 1, glutathione peroxidase (GPx), and thioredoxin. 38 Data from the earlier studies showed quercetin's capacity to block the route of luteinizing hormone -derived androgen production.…”

Section: Discussionmentioning

confidence: 99%

Dose Dependent Effects of Aqueous Extract of Garcinia cambogia Desr. Against Letrozole Induced Polycystic Ovarian Syndrome in Female Adult Rats With Possible Mechanisms Exploration

et al. 2023

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Background Polycystic ovarian syndrome (PCOS) is an endocrine metabolic disorder of women. Purpose This study aimed to explore the potential of aqueous extract of Garcinia cambogia Desr. (AEGC) in PCOS. Methodology The HPLC was used to determine the phytoconstituents present in Garcinia cambogia. Thirty adult female albino rats were divided into 6 groups: Normal control (NC) disease Control (PCOS; letrozole 1 mg/kg), plant extract (AEGC 100, 300, 500 mg/kg) and standard (metformin; 20 mg/kg). Disease was confirmed by vaginal smear cytology. After 10 weeks, animals were euthanized, ovaries dissected for histopathology, blood collected for hormonal and biochemical analysis. Results HPLC analysis showed the presence of phenolic contents; chlorogenic acid, gallic acid, coumaric acid while flavonoid contents were quercetin, kaempferol, and rutin. After treatment, there was dose dependent reduction of weight, ovarian cysts, improvement of follicle growth. DPPH radical scavenging percentage was 67.89%. Hormonal analysis showed a significant improvement ( P < .05) in follicle stimulating hormone (FSH), estrogen, and progesterone while a reduction in testosterone, luteinizing hormone (LH) and insulin level. Antioxidant enzymatic markers were significantly ( P < .05) increased. Lipid profile and LFTs were also improved. Conclusions The study validated the potential of Garcinia cambogia in the management of PCOS.

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Section: Discussionmentioning

confidence: 99%

Dose Dependent Effects of Aqueous Extract of Garcinia cambogia Desr. Against Letrozole Induced Polycystic Ovarian Syndrome in Female Adult Rats With Possible Mechanisms Exploration

et al. 2023

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Pharmacological Appraisal of Aqueous Ethanolic Extract of Cuminum cyminum (Cumin Seeds) in Obesity and Endocrinopathies Associated With Polycystic Ovarian Syndrome in Animal Models

Wang,

Barkat,

Amin

et al. 2024

Journal of Food Biochemistry

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A multidisciplinary endocrinopathy affecting women in their reproductive years, polycystic ovarian syndrome, causes insulin resistance, hyperandrogenism, cardiovascular issues, obesity, and menstrual difficulties. Cuminum cyminum (cumin seed) is a famous spice traditionally used for various ailments such as indigestion, headache, diarrhea, obesity, and gynecological disorders. This study explored the pharmacological potential of aqueous ethanolic extract of Cuminum cyminum (AECC) in letrozole‐induced PCOS animals, which were also obese. HPLC analysis revealed the presence of chlorogenic acid, gallic acid, hydroxybenzoic acid (HB acid), caffeic acid, vanillic acid, kaempferol, sinapic acid, ferulic acid, salicylic acid, coumarin, quercetin, benzoic acid, rutin, and p‐coumaric acid. Thirty adult female rats were divided into six groups (5 animals in each group). PCOS was induced by using letrozole (1 mg/kg). The groups were normal control, diseased control, standard (metformin, 20 mg/kg), and AECC (200, 400, and 600 mg/kg). Vaginal smear cytology was used to confirm the PCOS. The animals were euthanized after 12 weeks, and blood was drawn for hormonal and biochemical study. We used isoflurane 5% for euthanasia in a closed chamber. The ovaries were removed for histopathology. Ovarian histopathology showed abnormalities with cystic follicles in PCOS female rats. It also produced hyperinsulinemia, LH surge, lower FSH, perturbed LH/FSH ratio, and higher levels of testosterone and weight gain. Moreover, it also produced oxidative stress with ROS (reactive oxygen species) production. Meanwhile, AECC treatment converted cystic follicles into primary, secondary, and differentiating follicles with healthy granulosa cells and corpus luteum with significant (p < 0.001) weight loss. AECC significantly (p < 0.001) reduced serum insulin levels and normalized LH/FSH ratio, with improved FSH levels and control of LH surge. AECC also reduced oxidative stress and lipid peroxidation with significant (p < 0.001) improvement of antioxidant markers. It has been concluded that AEEC can alleviate PCOS symptoms by improving insulin resistance, reducing weight, addressing hyperandrogenism, regulating the LH/FSH ratio, and overcoming oxidative stress and ROS production.

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Influence of the Lipid Composition on the Properties, Technology and Quality Indicators of Liposomal Drugs

Pylypenko¹

2022

Biotechnol. acta

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Liposomal drug delivery system is an example of the use of nanodrugs in medical practice. Encapsulation of active pharmaceutical ingredients in liposomal nanoparticles allows increasing their bioavailability and efficacy. Aim. The article is devoted to the analysis of the lipid composition of liposomal drugs developed in Ukraine, its influence on the choice of technology and control parameters. Results. The lipid compositions of liposomal drugs developed in Ukraine in recent years were reviewed. The advantages and disadvantages of natural phosphatidylcholine as the main membrane-forming lipid were analyzed. Data on the influence of anionic phospholipids and cholesterol in the liposomal membrane composition on the stability of liposomal nanoparticles and the level of active pharmaceutical ingredient encapsulation were given. The main technological stages of obtaining liposomes with hydrophilic and hydrophobic active pharmaceutical ingredients were considered. The main groups of quality indicators of liposomal dosage forms have been determined. Conclusions. The lipid composition determines the structure and physicochemical properties of the lipid membrane, the mechanism and level of active pharmaceutical ingredient encapsulation, which significantly influences the pharmacological efficacy of liposomal drug delivery systems.

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Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease

Cited by 4 publications

References 33 publications

Dose Dependent Effects of Aqueous Extract of Garcinia cambogia Desr. Against Letrozole Induced Polycystic Ovarian Syndrome in Female Adult Rats With Possible Mechanisms Exploration

Dose Dependent Effects of Aqueous Extract of Garcinia cambogia Desr. Against Letrozole Induced Polycystic Ovarian Syndrome in Female Adult Rats With Possible Mechanisms Exploration

Pharmacological Appraisal of Aqueous Ethanolic Extract of Cuminum cyminum (Cumin Seeds) in Obesity and Endocrinopathies Associated With Polycystic Ovarian Syndrome in Animal Models

Influence of the Lipid Composition on the Properties, Technology and Quality Indicators of Liposomal Drugs

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