Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba)

Almeida

et al. 2021

RSD

The genus Trichilia (Meliaceae family) has been attracting interest among Brazilian Flora, due to the biological activities of its secondary metabolites. This genus has species distributed throughout tropical America, recognized for its significant economic importance and high commercial value. Its composition consists mainly of terpenoids (triterpenes, sesquiterpenes, limonoids and steroids) and polyphenols (flavonoids and tannins). In folk medicine this genus is used in preparations such as antimicrobial, antimalarial, antiviral and antioxidant. Studies carried out with several species of the genus Trichilia show that these plants have antioxidant, anticholinesterase, antimicrobial activities against pathogens of great clinical importance, neuroprotective, anti-anaphylactic and anti-inflammatory. In addition, analgesic, antineoplasic, hepatoprotective and immunomodulatory activities have also been investigated and proven in the literature. Based on the great biotechnological potential of the genus Trichilia, from the few studies on its applications in human health and in view of the importance of searching for natural substances that have effective therapeutic activities, this review highlights the main therapeutic applications of species of this genus found in the literature, and stimulate further studies on the use of these plants in the treatment of various diseases. For this, a survey on the topic was carried out in the main sources of scientific research in the period from 2005 to 2020, leading us to conclude that this genus can be a potent ally in the search for new phytotherapic drugs.

supporting

confidence: 71%

Review on the therapeutic activities of the genus Trichilia

Almeida

et al. 2021

RSD

“…Endurance-swimming time, forelimb-grip strength, and changes in biochemical marker levels were studied and a histological analysis of muscle and other tissues was performed to assess the fatigue in animal models [ 24 , 25 ]. Endurance-swimming time in a forced-swimming test, forelimb-grip test, and rotary rod test have been widely used in animal models for evaluating the anti-fatigue efficacy of drugs or natural compounds [ 26 , 27 ]. The enhancement of exercise endurance time is the key manifestation of the anti-fatigue effect of the drug or natural compounds.…”

Section: Discussionmentioning

confidence: 99%

Anti-Fatigue and Exercise Performance Improvement Effect of Glossogyne tenuifolia Extract in Mice

et al. 2022

Glossogyne tenuifolia (GT) is a native perennial plant growing across the coastline areas in Taiwan. The current study aimed to examine the efficacy of GT extract in ameliorating physical fatigue during exercise and increasing exercise performance. Fifty male Institute of Cancer Research (ICR) mice were randomly segregated into five groups (n = 10) to GT extract orally for 4 weeks, at different concentrations (50, 100, 250, and 500 mg/kg BW/day): LGT 1X, MGT 2X, HGT 5X, and HGT 10X groups. Forelimb grip strength, endurance swimming time, serum biochemical marker levels, blood lipid profile and histological analysis of various organs were performed to assess the anti-fatigue effect and exercise performance of GT extract. The forelimb-grips strength and endurance-swimming time of GT-administered mice were increased significantly in a dose-dependent manner when compared to the control. Serum glucose, creatine kinase, and lactate levels were increased significantly in the HGT 10X group. Liver marker serum glutamic-oxaloacetic transaminase (GOT) was increased in the HGT 5X and HGT 10X groups, whereas Serum Glutamic Pyruvic Transaminase (GPT) was not altered. Renal markers, creatinine and uric acid levels, were not altered. Muscle and hepatic glycogen levels, which are essential for energy sources during exercise, were also significantly increased in a dose-dependent manner in all GT extract groups. No visible histological aberrations were observed in the vital organs after GT extract administration. The supplementation with GT extract could have beneficial effects on exercise performance and anti-fatigue function without toxicity at a higher dose.

“…After that, the speed was increased at a rate of 1 m/min every 2 min. Mice were considered exhausted when they refused to run even if they were electrically stimulated [ 27 ]. On the last day, all mice rested for 30 min after running and were sacrificed.…”

Section: Methodsmentioning

confidence: 99%

Fermented Deer Blood Ameliorates Intense Exercise-Induced Fatigue via Modulating Small Intestine Microbiota and Metabolites in Mice

et al. 2021

Intense and excessive exercise-induced fatigue has become an important health issue and can damage intestinal health. Deer blood, as a food byproduct with nutritional value, has been found to restore physical strength. However, little is known about the antifatigue effect of fermented deer blood (FDB) on intense exercise mice. The purpose of the present study is to investigate the antifatigue effect of FDB, and whether this effect is correlated with the altered small intestinal microbiota and metabolites in exercise mice. In this study, 5-week-old male C57BL/6J mice are given treadmill exercise with or without FDB supplementation (30 and 150 mg/kg/d) for 3 weeks. FDB significantly reduces metabolic byproduct accumulation, liver and intestinal damage, and enhances glycogen storage and antioxidant capacity in intense exercise mice. Moreover, FDB restructures the small intestinal microbiota by increasing the abundance of probiotics and butyric acid producing bacteria and decreasing the abundance of pathogenic bacteria. FDB also regulates the levels of metabolites involved in TCA cycle and amino acid metabolism in urine and small intestine content. Correlation analysis shows that FDB-modulated microbiota is highly associated with its antifatigue effect. FDB may ameliorate fatigue and intestinal injury through targeting small intestinal microbiota.