Antioxidant Capacity of 55 Medicinal Herbs Traditionally Used to Treat The Urinary System: A Comparison Using A Sequential Three-Solvent Extraction Process

Wojcikowski, Ken; Stevenson, Lesley; Leach, D. L.; Wohlmuth, Hans; Gobé, Glenda C.

doi:10.1089/acm.2006.6122

Cited by 93 publications

(62 citation statements)

References 31 publications

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“…The ORAC method is preferred for the measurement of the antioxidant activity of foods and biological samples. Ninfali et al (2005) performed a comprehensive evaluation of different foods and spices using this method, Wojcikowski et al (2007) investigated the ORAC antioxidant activity of 55 medicinal plants and Kratchanova et al (2010) evaluated the ORAC antioxidant activity of 25 medicinal plants of Bulgaria. Tab.…”

Section: Oxygen Radical Absorbance Capacity (Orac)mentioning

confidence: 99%

Antioxidant Activity, Polyphenols Content and Antimicrobial Activity of Several Native Pteridophytes of Romania

Soare

Ferdeş

Stefanov

et al. 2012

Not Bot Hort Agrobot Cluj

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Section: Oxygen Radical Absorbance Capacity (Orac)mentioning

confidence: 99%

Antioxidant Activity, Polyphenols Content and Antimicrobial Activity of Several Native Pteridophytes of Romania

Soare

Ferdeş

Stefanov

et al. 2012

Not Bot Hort Agrobot Cluj

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“…°C, methanol at 40 °C, and water at 90 °C) and filtered (Whatman No. 3, gravity filtration) and then repeated for a second and third extraction (Wojcikowski et al, 2007). All the filtrates were vacuum dried using a rotary vacuum centrifuge.…”

Section: Introductionmentioning

confidence: 99%

Protection against oxidative stress-induced apoptosis in kidney epithelium by Angelica and Astragalus

Shahzad

Small

Morais

et al. 2016

Journal of Ethnopharmacology

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Ethnopharmacological relevance: Astragalus membranaceus either alone or in combination withAngelica sinensis has been used traditionally for kidney disease in East Asia and China for thousands of years. Previous studies using in vivo animal models have shown the benefits of these medicinal herbs in kidney diseases that involve oxidative stress. However, the mechanisms by which these medicinal herbs protect kidney cells remain largely unknown.Aim of the study: To investigate the mechanisms by which ethanol, methanol and aqueous crude extracts of roots of A. membranaceus and A. sinensis afford protection to human kidney proximal tubular epithelial cells, using an in vitro model of oxidative stress. Materials and Methods:Ethanol, methanol and aqueous extracts of roots of A. membranaceus and A. sinensis were prepared by a three-solvent sequential process. HK2 human kidney proximal tubular epithelial cells were treated with H 2 O 2 alone (0.5 mM) or in combination with different concentrations of extracts. Cell mitosis and death (microscopy) and cell viability (MTT assay) were compared. Western immunoblot was used to study expression of apoptosis-related proteins (pro-apoptotic Bax andanti-apoptotic Bcl-X L ), and cell survival (NFκB subunits p65 and p50), pro-inflammatory (TNF-α) and protective (TGFβ1) proteins.Results: H 2 O 2 -induced oxidative stress significantly increased apoptosis and reduced cell survival; upregulated pro-apoptotic and down-regulated Bcl-X L ; increased NFκB (p65, p50); increased TNFα; and decreased TGFβ1. All changes indicated kidney damage and dysfunction.All were modulated by all extracts of both plant species, except for NFκB which was only modulated by extracts of A. membranaceus. Conclusions:In conclusion, in a model of oxidative stress that might occur after nephrotoxicity, the plant extracts were protective via anti-apoptotic and anti-inflammatory mechanisms.3

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“…Water [27,19,53,54], methanol [55][56][57][58], and ethanol [59] have been widely used. In only a few cases, more than one extravagant or sequential multi-solvent extractions were preferred [58,59]. It has been recognized that the extraction solvent may significantly affect the properties of the extract [60,61].…”

Section: Extraction Techniquesmentioning

confidence: 99%

A Review of the Medicinal Plants in Bulgaria – Collection, Storage, and Extraction Techniques

Popova

Mihaylova

2018

Asian J Pharm Clin Res

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Objective: As old as humankind itself, plants have been used as a source of flavor, food preservatives, natural remedies, and ailments. As a part of human culture, medicinal plants are recognized for their healing properties, and the plant knowledge has successfully been transferred from generations to present days. Since natural ingredients enhance safety, medicinal plants' significance is constantly gaining interest because of the therapeutic phytochemicals that they contain. Methods and Results:The paper offers summarized information about the collection, storage, and extraction practices used in Bulgaria. A brief information regarding the distribution of the medicinal plants of the Bulgarian dendroflora is provided along with a review of the biological activities possessed. The various applications in the traditional and folk medicine are presented. Conclusion:Sustainable usage of medicinal plants plays a crucial to their conservation and increased healing potency. Thus, this paper reviews and emphasizes on the optimal collection, harvesting, and extracting approaches of medicinal plants.

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Antioxidant Capacity of 55 Medicinal Herbs Traditionally Used to Treat The Urinary System: A Comparison Using A Sequential Three-Solvent Extraction Process

Cited by 93 publications

References 31 publications

Antioxidant Activity, Polyphenols Content and Antimicrobial Activity of Several Native Pteridophytes of Romania

Antioxidant Activity, Polyphenols Content and Antimicrobial Activity of Several Native Pteridophytes of Romania

Protection against oxidative stress-induced apoptosis in kidney epithelium by Angelica and Astragalus

A Review of the Medicinal Plants in Bulgaria – Collection, Storage, and Extraction Techniques

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