Antioxidant compounds from Annona crassiflora fruit peel reduce lipid levels and oxidative damage and maintain the glutathione defense in hepatic tissue of Triton WR-1339-induced hyperlipidemic mice

Ramos, Letícia Pereira Afonso; Justino, Allisson Benatti; Tavernelli, Natália; Saraiva, André Lopes; Souza, Adriele Vieira de; Silva, Heitor Cappato Guerra; Moura, Francyelle Borges Rosa de; Botelho, Françoise Vasconcelos; Espíndola, Foued Salmen

doi:10.1016/j.biopha.2021.112049

Cited by 20 publications

(23 citation statements)

References 62 publications

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“…Lucas dos Santos et al [ 54 ] demonstrated that the aqueous extract from araticum pulp (1 mg/mL) reduced juglone-induced oxidative stress in wild-type (N2) strains of Caenorhabditis elegans , improving worm survival rate (32.2% survival) when compared to the control group (5.5% survival). Ramos et al [ 19 ] observed that the oral pretreatment of Triton WR-1339-induced hyperlipidemic mice, for 12 days with an ethanolic extract from araticum peel and its ethyl acetate fraction (10–100 mg/kg bw), was able to attenuate hyperlipidemia-induced oxidative stress in the mice liver by reducing hepatic lipid peroxidation and protein carbonylation, maintaining hepatic total thiol content, restoring hepatic GSH levels, and increasing hepatic antioxidant enzyme activities (SOD, CAT, GPx, GR, and G6PD). Likewise, Justino et al [ 55 ] verified an improved hepatic antioxidant status of streptozotocin-induced diabetic rats receiving a phenolic-rich fraction from araticum peel (25–100 mg/kg bw) for 30 days.…”

Section: Biological Activities Reported In Araticum Fruit Partsmentioning

confidence: 99%

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Arruda

Borsoi

Andrade

et al. 2023

Plants

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Araticum (Annona crassiflora Mart.) is a native and endemic species to Brazilian Cerrado whose fruits have high sensorial, nutritional, bioactive, and economic potential. Its use in local folk medicine, associated with recent scientific findings, has attracted growing interest from different industrial sectors. Therefore, understanding the scientific advances achieved so far and identifying gaps to be filled is essential to direct future studies and transform accumulated knowledge into innovative technologies and products. In this review, we summarize the phytochemical composition, bioactivities, and food products from araticum fruit that have been reported in the scientific literature over the past 10 years. The compiled data showed that araticum fruit parts contain a wide range of bioactive compounds, particularly phenolic compounds, alkaloids, annonaceous acetogenins, carotenoids, phytosterols, and tocols. These phytochemicals contribute to different biological activities verified in araticum fruit extracts/fractions, including antioxidant, anti-inflammatory, anti-Alzheimer, anticancer, antidiabetic, anti-obesity, antidyslipidemic, antinociceptive, hepatoprotective, healing of the cutaneous wound, antibacterial, and insecticide effects. Despite the promising findings, further studies—particularly toxicological (especially, with byproducts), pre-clinical, and clinical trials—must be conducted to confirm these biological effects in humans and assure the safety and well-being of consumers.

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Section: Biological Activities Reported In Araticum Fruit Partsmentioning

confidence: 99%

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Arruda

Borsoi

Andrade

et al. 2023

Plants

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“…There was an increase in liver GR activity between HL-control and E-WSC + 150 and HL+ E-WSC + 300 (*P < .05). In a similar study, Ramos et al 72 determined that ethanol extract of A. crassiflora fruit peel increased HDL-C and lowered cholesterol and hepatic triglyceride in hyperlipidemic mice induced by Triton WR-1339. They found that the antioxidant effects of A. crassiflora were noticeably stronger than those of the crude extract, with particular attention paid to the decrease in protein carbonylation and lipid peroxidation as well as the improved restoration and thiol content of liver GSH-Px, GR, and 73 The hypolipidemic activity of Phellinus rimosus Paraoxonase-1 (PON1) is one of the primary systems that guards the cell against oxidative stress PON1 is an antioxidant enzyme that is present in the membranes of the majority of cells as well as in the bloodstream attached to HDL.…”

Section: Resultsmentioning

confidence: 88%

“…There was an increase in liver GR activity between HL‐control and E‐WSC + 150 and HL+ E‐WSC + 300 (* P < .05). In a similar study, Ramos et al 72 determined that ethanol extract of A. crassiflora fruit peel increased HDL‐C and lowered cholesterol and hepatic triglyceride in hyperlipidemic mice induced by Triton WR‐1339. They found that the antioxidant effects of A. crassiflora were noticeably stronger than those of the crude extract, with particular attention paid to the decrease in protein carbonylation and lipid peroxidation as well as the improved restoration and thiol content of liver GSH‐Px, GR, and GSH.…”

Section: Resultsmentioning

confidence: 88%

Assessment of hypolipidemic and anti‐inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR‐1339‐induced hyperlipidemia in rat kidney, liver, and heart

Palabıyık

Sulumer

Uguz

et al. 2022

J of Molecular Recognition

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Atherosclerosis and cognitive impairment are both influenced by hyperlipidemia. Due to their high margin of safety and low cost, natural chemicals have recently attracted particular attention in the context of the treatment of disease. Hence, the purpose of this study was to investigate the possible amendatory impact of ethanol extract walnut (Juglans regia) seed coat (E‐WSC) on some metabolic enzymes (glutathione reductase (GR), paraoxonase‐1 (PON1), aldose reductase (AR), sorbitol dehydrogenase (SDH), acetylcholinesterase (AChE), glutathione S‐transferase (GST), and butyrylcholinesterase (BChE)) activity in the liver, kidney, and heart of rats with Triton WR‐1339‐induced hyperlipidemia. Rats were divided into five groups: control group, HL‐Control group (Triton WR‐1339 400 mg/kg, i.p administered group), E‐ WSC + 150 (150 mg/kg,o.d given group), E‐ WSC + 300 (E‐ WSC 300 mg/kg, o.d given group) and HL+ E‐WSC + 300 (Group receiving E‐ WSC 300 mg/kg, o.d 30 min prior to administration of Triton WR‐1339 400 mg/kg, i.p). In HL‐Control, AR, SDH, and BChE enzyme activity was significantly increased in all tissues compared to the control, while the activity of other studied enzymes was significantly decreased. The effects of hyperlipidemia on balance were improved and alterations in the activity of the investigated metabolic enzymes were prevented by E‐WSC. As a result, promising natural compounds that can be used as adjuvant therapy in the treatment of cognitive disorders and hyperlipidemia may be found in E‐WSC powder.

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“…GSH is a natural endogenous antioxidant produced by the liver as a peroxidase scavenger [ 151 ]. Consequently, it plays an essential role in treating cisplatin-induced sciatic nerve impairment.…”

Section: Resultsmentioning

confidence: 99%

Sustainable Release of Propranolol Hydrochloride Laden with Biconjugated-Ufasomes Chitosan Hydrogel Attenuates Cisplatin-Induced Sciatic Nerve Damage in In Vitro/In Vivo Evaluation

et al. 2022

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Peripheral nerve injuries significantly impact patients’ quality of life and poor functional recovery. Chitosan–ufasomes (CTS–UFAs) exhibit biomimetic features, making them a viable choice for developing novel transdermal delivery for neural repair. This study aimed to investigate the role of CTS–UFAs loaded with the propranolol HCl (PRO) as a model drug in enhancing sciatica in cisplatin-induced sciatic nerve damage in rats. Hence, PRO–UFAs were primed, embedding either span 20 or 60 together with oleic acid and cholesterol using a thin-film hydration process based on full factorial design (24). The influence of formulation factors on UFAs’ physicochemical characteristics and the optimum formulation selection were investigated using Design-Expert® software. Based on the optimal UFA formulation, PRO–CTS–UFAs were constructed and characterized using transmission electron microscopy, stability studies, and ex vivo permeation. In vivo trials on rats with a sciatic nerve injury tested the efficacy of PRO–CTS–UFA and PRO–UFA transdermal hydrogels, PRO solution, compared to normal rats. Additionally, oxidative stress and specific apoptotic biomarkers were assessed, supported by a sciatic nerve histopathological study. PRO–UFAs and PRO–CTS–UFAs disclosed entrapment efficiency of 82.72 ± 2.33% and 85.32 ± 2.65%, a particle size of 317.22 ± 6.43 and 336.12 ± 4.9 nm, ζ potential of −62.06 ± 0.07 and 65.24 ± 0.10 mV, and accumulatively released 70.95 ± 8.14% and 64.03 ± 1.9% PRO within 6 h, respectively. Moreover, PRO–CTS–UFAs significantly restored sciatic nerve structure, inhibited the cisplatin-dependent increase in peripheral myelin 22 gene expression and MDA levels, and further re-established sciatic nerve GSH and CAT content. Furthermore, they elicited MBP re-expression, BCL-2 mild expression, and inhibited TNF-α expression. Briefly, our findings proposed that CTS–UFAs are promising to enhance PRO transdermal delivery to manage sciatic nerve damage.

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Antioxidant compounds from Annona crassiflora fruit peel reduce lipid levels and oxidative damage and maintain the glutathione defense in hepatic tissue of Triton WR-1339-induced hyperlipidemic mice

Cited by 20 publications

References 62 publications

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Scientific Advances in the Last Decade on the Recovery, Characterization, and Functionality of Bioactive Compounds from the Araticum Fruit (Annona crassiflora Mart.)

Assessment of hypolipidemic and anti‐inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR‐1339‐induced hyperlipidemia in rat kidney, liver, and heart

Sustainable Release of Propranolol Hydrochloride Laden with Biconjugated-Ufasomes Chitosan Hydrogel Attenuates Cisplatin-Induced Sciatic Nerve Damage in In Vitro/In Vivo Evaluation

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