Antioxidant constituents from <i>Cotoneaster racemiflora</i>

Khan, Shafiullah; Riaz, Naheed; Afza, Nighat; Malik, Abdul; Aziz-Ur-Rehman, -; Iqbal, Lubna; Lateef, Mehreen

doi:10.1080/10286020802435745

Cited by 39 publications

(34 citation statements)

References 7 publications

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“…Mangroves or their associates were the sources of antiviral cyclohexylideneacetonitriles 1363-1366 (Bruguiera gymnorrhiza), 1003 The absolute conguration of the lignin rhamnoside 1376 was secured via analysis of experimental ECD datathe planar structure is identical to that of a previously reported metabolite of Cotoneaster racemiora though with different magnitude and opposite sign of rotation. 1012 CD analysis and an X-ray study has led to the revision of the structure of rhizophorin A (Rhizophora mucronata) 1013 to that shown for excolide A 1377. 1008 The structure of excolide B 1380 was also secured by X-ray analysis.…”

Section: Mangrovesmentioning

confidence: 99%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Mangrovesmentioning

confidence: 99%

Marine natural products

et al. 2017

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“…Isofraxidin is a coumarin compound that primarily exists in plants such as Sarcandraglabra and Acanthopanaxsenticosus (9). Isofraxidin has been reported to exhibit antibacterial, antioxidant, antidepressant and anti-inflammatory properties (10)(11)(12). Recently, isofraxidin was demonstrated to exert antitumor effects on two human colorectal adenocarcinoma cell lines, as the proliferation of HT-29 and SW-480 cells was inhibited by exposure to isofraxidin (9).…”

Section: Introductionmentioning

confidence: 99%

Anticancer effects of isofraxidin against A549 human lung cancer cells via the EGFR signaling pathway

et al. 2018

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Lung cancer is the leading cause of mortality due to tumor malignancy worldwide. In recent years, the treatment of lung cancer with chemotherapy has demonstrated notable resistance and insensitivity. Therefore, it is of great importance to investigate anti‑lung cancer drugs with high efficiency and low toxicity. In the present study, the effects of isofraxidin on lung cancer cells and the associated mechanisms were investigated. The results revealed that, in vivo and in vitro, isofraxidin exhibited marked inhibitory effects on the A549 lung cancer cell line. The results of Cell Counting kit‑8, Transwell migration and Matrigel invasion assays, and flow cytometry to determine apoptosis, revealed that isofraxidin significantly inhibited the proliferation, migration and invasion of A549 cells, and induced the cell apoptosis. Furthermore, western blot analysis demonstrated that isofraxidin treatment led to effects on the expression of apoptosis‑associated proteins, including members of the Bcl‑2 protein family, and invasion‑associated proteins, including matrix metallopeptidase (MMP)‑2 and MMP‑9, which may occur via inhibition of the expression of phosphorylated (p)‑epidermal growth factor receptor, p‑AKT and p‑extracellular signal‑regulated kinase. This regulation of protein expression may contribute to the inhibition of proliferation, migration and invasion of A549lung cancer cells by isofraxidin. In addition, despite the inhibitory effects on the A549 lung cancer cell line, the present study revealed that isofraxidin exhibited low toxicity towards BEAS‑2B normal lung epithelial cells within a certain dose range (0‑160 µM), indicating that isofraxidin may be employed for lung cancer treatment with hypotoxicity and fewer side effects. In conclusion, isofraxidin may be a novel candidate for anti‑lung cancer chemotherapy.

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“…Hydroxycoamarins especially scopoletin and isofraxidin are also other compounds identified in elm bark albeit in lower concentrations (Martin et al 2004). Some of beneficial effects of isofraxidin have been reported to be inhibition of pro-inflammatory cytokines (Liu et al 2015), inhibition of lipid production and inflammation in the liver (Li et al 2017), anti-oxidant and anti-bacterial properties (Khan et al 2009). Scopoletin is a coumarin (7-hydroxy 6-methoxycoumarin) compound which, based on previous studies, has beneficial effects such as antioxidant (Shaw et al 2003), anti-tumoral (Liu et al 2012), anti-inflammatory (Ding et al 2008;Leema and Tamizhselvi 2018), hypoglycemic and hypolipidemic activity (Verma et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Ulmus minor bark hydro-alcoholic extract ameliorates histological parameters and testosterone level in an experimental model of PCOS rats

Hoseinpour

Ghanbari

Azad

et al. 2019

Endocrine Regulations

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Objective. Polycystic ovary syndrome (PCOS) is a common and multifactorial disease associated with female factor infertility. Ulmus minor bark (UMB) is one of the medicinal plants used in Persian folklore as a fertility enhancer. In the current study, we aimed to elucidate the effect of UMB hydro-alcoholic extract on histological parameters and testosterone condition in an experimental model of PCOS rats.Methods. Thirty female rats were randomly divided into five groups: (1) control, (2) vehicle, (3) PCOS/50 mg [6 mg/kg dehydroepiandrosterone (DHEA) + 50 mg/kg UMB hydro-alcoholic extract], (4) PCOS/150 mg (6 mg/kg DHEA + 150 mg/kg UMB hydro-alcoholic extract), and (5) PCOS (6 mg/kg DHEA). All interventions were performed for 21 days. Afterwards, stereological analysis was done for determination of ovarian volume and follicle number. The serum level of testosterone was measured by ELISA kit.Results. UMB hydro-alcoholic extract improved the total number of the corpus luteum in the treatment groups when compared to the PCOS group (p<0.05). PCOS/150 mg and PCOS/50 mg groups showed significantly lower total number of the primordial, primary, and secondary follicles as well as testosterone level compared to the PCOS group (p<0.05). The total number of antral follicles and volume of ovary did not differ significantly between groups.Conclusion. UMB extract may be an effective and good alternative in improving PCOS histological and testosterone disturbances although further studies are warranted to confirm the safety of UMB plant in human.

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Antioxidant constituents from Cotoneaster racemiflora

Cited by 39 publications

References 7 publications

Marine natural products

Marine natural products

Anticancer effects of isofraxidin against A549 human lung cancer cells via the EGFR signaling pathway

Ulmus minor bark hydro-alcoholic extract ameliorates histological parameters and testosterone level in an experimental model of PCOS rats

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