Antioxidant, Cytotoxic Activities, and Structure–Activity Relationship of Gallic Acid‐based Indole Derivatives

Khaledi, Hamid; Alhadi, Abeer A.; Yehye, Wageeh A.; Ali, Hapipah Mohd; Abdulla, Mahmood Ameen; Hassandarvish, Pouya

doi:10.1002/ardp.201000223

Cited by 42 publications

(30 citation statements)

References 35 publications

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“…9 Among polyphenols, gallic acid derivatives are a well-known group of naturally occurring compounds which have been found in many phytomedicines. 11 The antioxidant activity of plant extracts or isolated secondary metabolites can be determined using different methods. The commonest Chlorogenic acid 67.9 ± 0.10 method is the chemical assay, which is based on the ability, to scavenge various kinds of free radicals and uses DPPH (1, 1-diphenyl-2-picrylhydrazyl).…”

Section: Resultsmentioning

confidence: 99%

Gallic Acid Derivatives (GADs) from Loranthus micranthus Linn. Parasitic on Hevea brasiliensis with Antioxidative Capacity

Agbo

Witika

Parker

et al. 2016

Dhaka Univ. J. Pharm. Sci

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Section: Resultsmentioning

confidence: 99%

Gallic Acid Derivatives (GADs) from Loranthus micranthus Linn. Parasitic on Hevea brasiliensis with Antioxidative Capacity

Agbo

Witika

Parker

et al. 2016

Dhaka Univ. J. Pharm. Sci

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“…A series of 2-(3,4,5-trihydroxy phenyl)-5-aryl-1,3,4-oxadiazole were synthesized and evaluated for their anti-tubercular activity [17]. A series of gallic hydrazones containing an indole moiety were evaluated for cytotoxic and antioxidant activities [18]. Derivatives such as 5-{6-(substituted phenyl)-5,6-dihydro- (1,2,4) triazolo(3,4-b)(1,3,4) thiadiazol-3-yl}benzene-1,2,3-triol were synthesized and screened for antimicrobial and anti-inflammatory effects [19].…”

Section: Camentioning

confidence: 99%

Gallic Acid: A Promising Lead Molecule for Drug Development

Nayeem¹,

SMB²

2016

J App Pharm

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Gallic acid and its congeners are commonly present in variety of fruits and number of plants. In addition to its natural origin, large number of synthesized gallic acid derivatives are also available. It has a wide range of industrial uses including its role as standard for determing phenolic content of analytes in pharmaceutical industry, as source material for ink, paints and colour developer. Studies on gallic acid and its derivatives have exhibited its potential for combating oxidative damages, cancer manifestations and microbial infestations. Further, gallic acid extracted from different natural sources has been implicated to possess potency to ameliorate neurodegenerative disorders and aging. Furthermore, large number of reseach explorations are available to show its ability for the treatment of diabetes, ischemic heart diseases, ulcer and other ailments. In this review, an attempt is made to compile the scattered information on gallic acid and its derivatives for their pharmacological role, isolation and extraction procedures as well as quantification. This might help our research fraternity to explore gallic acid in their future research as a lead compound for new drug development.

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“…Consequently, e-viniferin becomes richer phi electrons with the equitable electrons distribution from the ring B1 to B2 through electron delocalization. It will produce a more stable radical that can inhibit cancer cell growth [31]. Biological activity of hopeaphenol and a-viniferin against human breast cancer cell lines T-47D thought to be caused by the density of the compound [32].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Cytotoxic Potencies of Stilbene Oligomers From Stem Barks of Baoti (Dryobalanops Lanceolata) Growing in Kendari, Indonesia

Sahidin

Wahyuni²,

Malaka³

et al. 2017

Asian J Pharm Clin Res

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Objective: The purpose of the research is to isolate and to identify compounds from stem barks of Dryobalanops lanceolata and to evaluate their activities toward bacteria and cancer cell lines. Methods:Isolation of the compounds worked with chromatography methods including thin-layer chromatography, vacuum liquid chromatography, and radial chromatography. All compound structures were determined based on the spectroscopic evidence including ultraviolet (UV), Infrared, and one-dimension and two-dimension nuclear magnetic resonance spectra and comparison the spectroscopy data with related data from references. The biological properties of compounds are evaluated toward bacteria Escherichia coli ATCC 35219 and Staphylococcus aureus ATCC 25923 and human breast cancer cell lines T-47D as cytotoxic potency.Results: Five stilbene oligomers have been isolated and identified from acetone extract of D. lanceolata stem barks namely balanocarpol (1), e-viniferin (2), a-viniferin (3), vaticanol B (4), and hopeaphenol (5). The inhibition zone value (in mm) of e-viniferin, balanocarpol, a-viniferin, hopeaphenol, and vaticanol B toward E. coli and S. aureus is 11±0.22 and 7±0.17, 9±0.17 and 13±0.12, 8±0.20 and 8±0.16, 6±0.16 and 8±0.11, and 5±0.12 and 4±0.14, respectively. Biological activity of the compounds against breast cancer cell lines T-47D (inhibitory concentration 50% in µM) for e-viniferin, balanocarpol, a-viniferin, hopeaphenol, and vaticanol B is 34.13±0.15, 98.17±0.41, 84.79±0.24, 52.04±0.26, and 119.30±0.54, respectively.Conclusions: e-viniferin is the most active compound toward E. coli and human breast cancer cell lines T-47D. Biological activity against bacteria S. aureus indicated that balanocarpol is the most potential compound.

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Antioxidant, Cytotoxic Activities, and Structure–Activity Relationship of Gallic Acid‐based Indole Derivatives

Cited by 42 publications

References 35 publications

Gallic Acid Derivatives (GADs) from Loranthus micranthus Linn. Parasitic on Hevea brasiliensis with Antioxidative Capacity

Gallic Acid Derivatives (GADs) from Loranthus micranthus Linn. Parasitic on Hevea brasiliensis with Antioxidative Capacity

Gallic Acid: A Promising Lead Molecule for Drug Development

Antibacterial and Cytotoxic Potencies of Stilbene Oligomers From Stem Barks of Baoti (Dryobalanops Lanceolata) Growing in Kendari, Indonesia

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