Antioxidant dihydrolipolic acid protects against in vitro aluminum‐induced toxicity

Sanajou, Sonia; Yirün, Anıl; Demirel, Göksun; Cakir, Deniz Arca; Şahin, Gönül; Erkekoğlu, Ülfet Pinar; Baydar, Terken

doi:10.1002/jat.4513

Cited by 8 publications

(6 citation statements)

References 72 publications

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“…17 Similarly, dihydrolipoic acid, a natural antioxidant, upregulates PPA2 in neuroblastoma cells. 21 Diphenyl difluoroketone (EF-24), a curcumin analog, induces apoptosis of acute myeloid leukemia cells by upregulating PP2A. 22 Polyphenol (À)-epigallocatechin-3-O-gallate (EGCG) upregulates laminin receptordependent PP2A in melanoma cells.…”

Section: Cancer Cell Model Studies For Pp2a-inducing Natural Productsmentioning

confidence: 99%

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Chuang,

Yen,

Tang

et al. 2024

Environmental Toxicology

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Protein phosphatase 2A (PP2A), a heterotrimeric holoenzyme (scaffolding, catalytic, and regulatory subunits), regulates dephosphorylation for more than half of serine/threonine phosphosites and exhibits diverse cellular functions. Although several studies on natural products and miRNAs have emphasized their impacts on PP2A regulation, their connections lack systemic organization. Moreover, only part of the PP2A family has been investigated. This review focuses on the PP2A‐modulating effects of natural products and miRNAs' interactions with potential PP2A targets in cancer and non‐cancer cells. PP2A‐modulating natural products and miRNAs were retrieved through a literature search. Utilizing the miRDB database, potential PP2A targets of these PP2A‐modulating miRNAs for the whole set (17 members) of the PP2A family were retrieved. Finally, PP2A‐modulating natural products and miRNAs were linked via a literature search. This review provides systemic directions for assessing natural products and miRNAs relating to the PP2A‐modulating functions in cancer and disease treatments.

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Section: Cancer Cell Model Studies For Pp2a-inducing Natural Productsmentioning

confidence: 99%

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Chuang,

Yen,

Tang

et al. 2024

Environmental Toxicology

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“…The ROS production of control group was 100%, and the ROS production by other groups was calculated as a percentage of the control (Yirün et al, 2023;Sanajou, Yirün et al, 2023).…”

Section: Intracellular Rosmentioning

confidence: 99%

Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum‐induced neurotoxicity in an in vitro Alzheimer's disease model

Demirel,

Sanajou,

Yirün

et al. 2023

J of Applied Toxicology

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Alzheimer's disease (AD) is a progressive neurological disorder that affects various cognitive functions, behavior, and personality. AD is thought to be caused by a combination of genetic and environmental factors, including exposure to aluminum (Al). Virgin coconut oil (VCO) may have potential as a natural neuroprotectant against AD. Aim of this study was to determine neuroprotective effects of VCO on Al‐induced neurotoxicity in an in vitro AD model. SH‐SY5Y cells were initially cultured in normal growth medium and then differentiated by reducing fetal bovine serum content and adding retinoic acid (RA). Later, brain‐derived neurotrophic factor (BDNF) was added along with RA. The differentiation process was completed on the seventh day. Study groups (n = 3) were designed as control group, VCO group, Al group, Al‐VCO group, Alzheimer model (AD) group, AD + Al‐exposed group (AD+Al), AD + VCO applied group (AD + VCO) and AD + Al‐exposed + VCO applied group (AD + Al + VCO). Specific markers of AD (hyperphosphorylated Tau protein, amyloid beta 1–40 peptide, and amyloid precursor protein) were measured in all groups. In addition, oxidative stress parameters (total antioxidant capacity, lipid peroxidase, protein carbonyl, and reactive oxygen species) and neurotransmitter‐related parameters (dopamine, dopamine transporter acetylcholine, and synuclein alpha levels, acetylcholinesterase activity) were measured comparatively in the study groups. VCO reduced amyloid beta and hyperphosphorylated Tau protein levels in the study groups. In addition, oxidative stress levels decreased, and neurotransmitter parameters improved with VCO. Our study shows that VCO may have potential therapeutic effects in Alzheimer's disease and further experiments are needed to determine its efficacy.

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“…Increased NRF2 levels in the cytoplasm phosphorylate the BAX apoptotic protein, which is further involved in the release of cytochrome-c from the mitochondria, leading to apoptosis activity. On the other hand, Al also activates GSK3 beta by inhibiting AKT and Wnt signaling pathways, which are further responsible for hyperphosphorylation of the tau protein, leading to synaptoxicity ( Kawahara et al, 1994 ; Hong and An, 2018 ; Sanajou et al, 2023 ).…”

Section: Different Agents Used For Induction Of Alzheimer Diseasementioning

confidence: 99%

A systematic review for the development of Alzheimer’s disease in in vitro models: a focus on different inducing agents

Prajapat,

Kaur,

Choudhary

et al. 2023

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease and is associated with dementia. Presently, various chemical and environmental agents are used to induce in-vitro models of Alzheimer disease to investigate the efficacy of different therapeutic drugs. We screened literature from databases such as PubMed, ScienceDirect, and Google scholar, emphasizing the diverse targeting mechanisms of neuro degeneration explored in in-vitro models. The results revealed studies in which different types of chemicals and environmental agents were used for in-vitro development of Alzheimer-targeting mechanisms of neurodegeneration. Studies using chemically induced in-vitro AD models included in this systematic review will contribute to a deeper understanding of AD. However, none of these models can reproduce all the characteristics of disease progression seen in the majority of Alzheimer’s disease subtypes. Additional modifications would be required to replicate the complex conditions of human AD in an exact manner. In-vitro models of Alzheimer’s disease developed using chemicals and environmental agents are instrumental in providing insights into the disease’s pathophysiology; therefore, chemical-induced in-vitro AD models will continue to play vital role in future AD research. This systematic screening revealed the pivotal role of chemical-induced in-vitro AD models in advancing our understanding of AD pathophysiology and is therefore important to understand the potential of these chemicals in AD pathogenesis.

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Antioxidant dihydrolipolic acid protects against in vitro aluminum‐induced toxicity

Cited by 8 publications

References 72 publications

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum‐induced neurotoxicity in an in vitro Alzheimer's disease model

A systematic review for the development of Alzheimer’s disease in in vitro models: a focus on different inducing agents

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