Antioxidant effect of Ajuga iva aqueous extract in streptozotocin-induced diabetic rats

Taleb-Senouci, D.; Ghomari, H. El; Krouf, Djamil; Bouderbala, Sherazede; Prost, Josiane; Lacaille‐Dubois, Marie‐Aleth; Bouchenak, Malika

doi:10.1016/j.phymed.2008.12.004

Cited by 49 publications

(28 citation statements)

References 35 publications

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“…The deleterious effects of superoxide anion and hydroxyl radical are counteracted by antioxidant enzymes, such as, SOD, GSH and CAT (Taleb-Senouci et al, 2009). The results showed the elevated levels of these enzymes in diabetic rats, which were diminished in the BNRE treated rats and were in compliance with that of the rats treated with glibenclamide (Table 4).…”

Section: Discussionmentioning

confidence: 80%

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Sancheti¹,

Bafna²,

Kim³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The potential role of 80% methanolic extract of Boehmeria nivea (L.) Gaudich., Urticaceae, root in the treatment of diabetes, along with its antihyperlipidemic and antioxidant effects, was studied in streptozotocin-induced diabetic male Wistar rats. Preliminary screening of the extract revealed the presence of polyphenolics and fl avonoids. The animal study was conducted with variable doses of 125, 250 and 500 mg/ kg of extract for 21 days in diabetic rats. A signifi cant effect was observed at a dose of 500 mg/kg, which was comparable to the standard drug, glibenclamide. Administration of the extract at a 500 mg/kg dose resulted in a signifi cant reduction of fasting blood glucose, total cholesterol, triglycerides, blood urea, alanine aminotransferase, aspartate aminotransferase, urine sugar and urine ketone levels in diabetic rats in comparison with the diabetic control group. Additionally, this dose signifi cantly increased body weight, hemoglobin, plasma total protein, high density lipoprotein cholesterol, liver glycogen content, superoxide dismutase, reduced glutathione and catalase levels in diabetic rats at the end of 21 days of treatment. Therefore, dietary supplementation with Boehmeria nivea root extract could be benefi cial for correcting hyperglycemia, hyperlipidemia and enhancing the antioxidant defense system. Keywords

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Section: Discussionmentioning

confidence: 80%

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Sancheti¹,

Bafna²,

Kim³

et al. 2011

Rev. bras. farmacogn.

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“…In in vitro studies, KRL has been used to assess the antioxidant power of various synthetic and natural substances (Blache et al, 1991;Rossi et al, 2009). Some studies on the antioxidant defences in animals, using the KRL test, have been published, particularly on rats (Taleb-Senouci et al, 2009) and birds (Bertrand et al,. 2006).…”

Section: Introductionmentioning

confidence: 99%

Kit Radicaux Libres, A Biological Application for Monitoring Oxidative Stress in Pigs

Pastorelli

Faustini

Corino

et al. 2013

Italian Journal of Animal Science

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Kit Radicaux Libres (KRL) test is a biological application, successfully applied on humans, helpful for the study of the total antiradical activity. In the present work, the first objective was to test on a subset of pig blood samples in order to determine the maximum time of storage able to provide reliable results. Blood samples were collected from 46 piglets and determinations were carried out on the blood samples after three h from collection (T1) and thereafter at 24 (T2) and 48 (T3) h. Successively blood samples from 313 piglets (171 castrated males and 142 females) were collected and analysed in order to determine reference intervals. Results are expressed as half-haemolysis time (HT50 in min), that is a reference point for blood susceptibility to free radical attack.Our findings showed that for samples analysed at T1 and T2 there were no significant changes but significantly increased values (P<0.05) were obtained when samples were analysed after 48 h from collection, underlining biological and analytical interference due to the hemolysis of the samples. The reference values found in the subjects, expressed as ET AL50 were 46.6-68.7 min (males) and 52.5-86.8 min (females) in RBC, in whole blood.In conclusion, a prolonged time (till +48 h) caused haemolysis, therefore the use of freshly collected blood is strictly recommended. The reference values obtained are considered to represent valid reference ranges for healthy pigs starting after weaning to 175 days of age under modern husbandry conditions.

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“…[6566] As for antioxidative effect, plant extracts such as green tea, Ajuga iva aqueous extract and Chlorogenic acid from Cecropia pachystachya are capable of reducing oxidative stress and protecting against tissue damage in diabetes. [415767] Another acting mechanism based on antioxidants such as kinsenoside, gymnemic acid and quercetin are helpful in preventing and treating Type I diabetes as they can regenerate the beta cells in islets of Langerhans in pancreas. [29525468]…”

Section: The Plant Extracts For Diabetes Treatment and Related Actingmentioning

confidence: 99%

A brief review on anti diabetic plants: Global distribution, active ingredients, extraction techniques and acting mechanisms

2012

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A study has been conducted with the aim to provide researchers with general information on anti diabetic extracts based on relevant research articles collected from 34 reliable medical journals. The study showed that Asian and African continents have 56% and 17% share of the worldwide distribution of therapeutic herbal plants, respectively. In Asia, India and China are the leading countries in herbal plants research, and there has been an increase in medicinal research on plants extract for diabetes treatment since 1995 in these regions. The information collected shows that plant leaves are about 20% more favorable for storing active ingredients, as compared to other parts of herbal plants. A brief review on the extraction techniques for the mentioned parts is also included. Furthermore, the acting mechanisms for the anti diabetic activity were described, and the related active ingredients were identified. The findings reveal that most of the anti diabetic research is focused on the alteration of glucose metabolism to prevent diabetes.

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Antioxidant effect of Ajuga iva aqueous extract in streptozotocin-induced diabetic rats

Cited by 49 publications

References 35 publications

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Kit Radicaux Libres, A Biological Application for Monitoring Oxidative Stress in Pigs

A brief review on anti diabetic plants: Global distribution, active ingredients, extraction techniques and acting mechanisms

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