Antioxidant effect of beta-carotene on hypoxia induced oxidative stress in male albino rats

Sarada, S.K.S; Dipti, P; Anju, B; Pauline, T; Kain, A. K.; Sairam, M.; Sharma, Shivani; Ilavazhagan, G.; Kumar, Devendra; Selvamurthy, W.

doi:10.1016/s0378-8741(01)00360-9

Cited by 52 publications

(35 citation statements)

References 22 publications

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“…Consumption lycopene and β-Carotene have been reported to be inverse with incidence of cancer [16]. Results obtained show that some of these vegetable contain high levels of lycopene and β-Carotene and an increase was observed for both contents in Lycopersicon esculentum due to ripeness while otherwise was observed for Capsicum frutescens.…”

Section: Phytochemical Contentsmentioning

confidence: 80%

“…Flavonoids, a class of phenolic co mpounds has been shown to possess anti-inflammatory, antiviral, anticarcinogenic, antithrombotic, antiallergic and hepatoprotective [15]. Carotenes have been proved to possess antioxidant activity due to their ability to quench singlet oxygen and inhibit lip id pero xidation [16]. Thus, diets rich in fru its and vegetables are believed to play an important role in preventing diseases but human choices of diet are driven by necessity and economy.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity and Phytochemical Contents of Some Selected Nigerian Fruits and Vegetables

Azeez¹,

D²,

A³

et al. 2012

CHEMISTRY

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Ten plants which are used as condiments, spices, herbs, and eaten raw in Nigeria were investigated for their antioxidant activit ies using 2, 2-diphenyl-1-p icrylhydrazyl (DPPH) method. Phytochemicals such as total phenols, flavonoids, β-Carotene, and lycopene were also determined. The results showed that the highest antioxidant activity was found in Lactuca sativa (92.62%) and Allium sativum had the lowest (4.32%). Lactuca sativa with the lowest IC 50 (0.26mg/ mL), is the most potent vegetable of the samples analyzed. Phenolic contents of fruits and vegetables ranged from 106mg quercetin/g of extract for Capsicum annuum to 360mg quercetin/g of extract for Lycopersicon esculentum (unripe) wh ile flavonoid contents ranged from 64 mg quercetin/g of extract for Daucus carota to 482 mg quercetin/g of extract for Zingiber officinale. Ripe Lycopersicon esculentum and Capsicum frutescens have higher Phenolic and Flavonoid contents than the unripe ones. There was significant correlation (r = 0.63, p< 0.05) between antio xidant activity and flavonoid contents but phenolic contents poorly correlate with antio xidant activity (r = 0.31, p< 0.05) of samples analyzed. Zingiber officinale had the highest content of β-carotene (66.30µg/g of extract) and Allium sativum had the lowest (2.37µg/g of ext ract). Ripe Lycopersicon esculentum (22.73µg/g of ext ract) had the highest lycopene and Allium sativum had the lo west (1.23µg/g of ext ract). Ripe Lycopersicon esculentum has higher lycopene and β-carotene contents than the unripe ones, but a decrease was obtained for Capsicum frutescens upon ripening. Both β-carotene and lycopene poorly correlate with antio xidant activity but significantly correlate with each other. These fruits and vegetables can be considered as good sources of antioxidants as shown by the values obtained for antio xidant activity, phenolic, flavonoid, β-carotene and lycopene contents.

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Section: Phytochemical Contentsmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Phytochemical Contents of Some Selected Nigerian Fruits and Vegetables

Azeez¹,

D²,

A³

et al. 2012

CHEMISTRY

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“…Hypoxia has been previously shown to increase lipid peroxidation in a variety of other biological systems. After hypoxia, levels of the lipid peroxidation indicator MDA increase in plasma and tissues of male albino rats (Kurhaliuk, 2001;Sarada et al, 2002), lung of adult human skiers (Gü zel et al, 2000), and plasma of human perinatal fetus (Schmidt et al, 1996) and newborn infants (Buonocore et al, 1998). Hypoxia also induces an increase in MDA in liver, brain, and heart of chicken embryo (Stock et al, 1990) and rat heart (Chen et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Inducible Nitric-Oxide Synthase Protects Human T Cells from Hypoxia-Induced Apoptosis

Kiang¹,

Krishnan²,

Lu³

et al. 2007

Mol Pharmacol

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Sodium cyanide-induced chemical hypoxia triggers a series of biochemical alterations leading to apoptosis in many cell types, including T cells. It is known that chemical hypoxia promotes inducible nitric-oxide synthase (iNOS) gene transcription by activating its transcription factors. To determine whether iNOS and NO production are responsible for chemical hypoxia-induced apoptosis, we exposed human Jurkat T cells to sodium cyanide in the presence or absence of iNOS inhibitors. We found that iNOS expression is necessary for hypoxia-induced lipid peroxidation and leukotriene B 4 generation. The inhibition of iNOS limited T-cell apoptosis by decreasing the activity of caspase-3 without affecting the expression of Fas/Apo-1/CD95 on the surface membrane of T cells. These data suggest iNOS-mediated NO produced endogenously in the T cell alters overall T-cell function and results in apoptosis. Proper control of iNOS expressed in the T cell may represent a useful approach to immunomodulation.

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“…Beta-carotene, the most abundant form of provitamin A, powerfully scavenges free radicals [6] and its consumption can reduce the risk of various disorders, like cardiac disease and cancer [7].…”

Section: Introductionmentioning

confidence: 99%

Beta Carotene Modulates Nitric Oxide Production in the Renal Ischemia/Reperfusion Injury in Rat

Badavi

Naseri

Pirmoradi

et al. 2017

Zahedan J Res Med Sci

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Background: Renal ischemia and subsequent reperfusion injury is a major cause of acute renal failure and transplant rejection. Nitric oxide and its metabolites have important role in renal ischemia/reperfusion injury. Beta carotene as an antioxidant effectively scavenges toxic metabolites of nitric oxide. Our previous study has shown that beta carotene pretreatment protects kidney against ischemia/reperfusion injury.

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Antioxidant effect of beta-carotene on hypoxia induced oxidative stress in male albino rats

Cited by 52 publications

References 22 publications

Antioxidant Activity and Phytochemical Contents of Some Selected Nigerian Fruits and Vegetables

Antioxidant Activity and Phytochemical Contents of Some Selected Nigerian Fruits and Vegetables

Inhibition of Inducible Nitric-Oxide Synthase Protects Human T Cells from Hypoxia-Induced Apoptosis

Beta Carotene Modulates Nitric Oxide Production in the Renal Ischemia/Reperfusion Injury in Rat

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