Antioxidant effect of diphenyl diselenide against sodium nitroprusside (SNP) induced lipid peroxidation in human platelets and erythrocyte membranes: An in vitro evaluation

Posser, Thaís; Moretto, Maria Beatriz; Dafre, Alcir Luiz; Farina, Marcelo; Rocha, João Batista Teixeira da; Nogueira, Cristina W.; Zeni, Gilson; Ferreira, Jovino dos Santos; Leal, Rodrigo Bainy; Franco, Jeferson Luís

doi:10.1016/j.cbi.2006.09.002

Cited by 43 publications

(21 citation statements)

References 52 publications

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“…The results of the current study also demonstrate that SNP did not change CAT and GPx activities in brains of mice, these data are in accordance with those reported in the literature (Yerer and Aydogan, 2004;Posser et al, 2006;Prigol et al, 2008). Therefore, it is possible that CAT and GPx may regulate the impact of SNP on the cell.…”

Section: Discussionsupporting

confidence: 95%

Antioxidant effect of a novel class of telluroacetilene compounds: Studies in vitro and in vivo

Souza¹,

Luchese²,

Neto³

et al. 2009

Life Sciences

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Section: Discussionsupporting

confidence: 95%

Antioxidant effect of a novel class of telluroacetilene compounds: Studies in vitro and in vivo

Souza¹,

Luchese²,

Neto³

et al. 2009

Life Sciences

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“…At 2 µM, this OS molecule significantly protected human platelets and restored GPX activity. These phenomena seem to be related to its thiol peroxidase-like activity (47). Hence DPDS is a promising antioxidant molecule.…”

Section: Antioxidant Effectsmentioning

confidence: 98%

Pharmacology and toxicology of diphenyl diselenide in several biological models

Rosa

Roesler

Braga

et al. 2007

Braz J Med Biol Res

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The pharmacology of synthetic organoselenium compounds indicates that they can be used as antioxidants, enzyme inhibitors, neuroprotectors, anti-tumor and anti-infectious agents, and immunomodulators. In this review, we focus on the effects of diphenyl diselenide (DPDS) in various biological model organisms. DPDS possesses antioxidant activity, confirmed in several in vitro and in vivo systems, and thus has a protective effect against hepatic, renal and gastric injuries, in addition to its neuroprotective activity. The activity of the compound on the central nervous system has been studied since DPDS has lipophilic characteristics, increasing adenylyl cyclase activity and inhibiting glutamate and MK-801 binding to rat synaptic membranes. Systemic administration facilitates the formation of long-term object recognition memory in mice and has a protective effect against brain ischemia and on reserpine-induced orofacial dyskinesia in rats. On the other hand, DPDS may be toxic, mainly because of its interaction with thiol groups. In the yeast Saccharomyces cerevisiae, the molecule acts as a pro-oxidant by depleting free glutathione. Administration to mice during cadmium intoxication has the opposite effect, reducing oxidative stress in various tissues. DPDS is a potent inhibitor of δ-aminolevulinate dehydratase and chronic exposure to high doses of this compound has central effects on mouse brain, as well as liver and renal toxicity. Genotoxicity of this compound has been assessed in bacteria, haploid and diploid yeast and in a tumor cell line.

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“…The anti-nociceptive, neuroprotective, hepatoprotective and antiinflammatory properties of (PhSe)2 have been demonstrated in different in vitro and in vivo experimental models (Borges et al, 2005;Ghisleni et al, 2003;Savegnago et al, 2007;Zasso et al, 2005). Furthermore, the antioxidant ability of (PhSe)2 has been shown in several in vitro systems containing different types of *Correspondence to: A. F. de Bem,Departamento de Bioquímica,Universidade Federal de Santa Catarina,88040900,Florianópolis,SC,Universidade Federal de Santa Catarina,Florianópolis,SC,88040900,Brazil b Departamento de Biologia Celular,Embriologia e Genética,Universidade Federal de Santa Catarina,Florianópolis,SC,88040900,Brazil c tissue, including brain, liver and platelets (Borges et al, 2005;Posser et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Acute exposure of rabbits to diphenyl diselenide: a toxicological evaluation

Straliotto

Mancini

Oliveira

et al. 2010

J of Applied Toxicology

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The simple organoselenium compound diphenyl diselenide (PhSe)(2) is a promising new pharmacological agent. However, few toxicological evaluations of this molecule have been reported. We evaluated the effects of acute administration of (PhSe)(2) on toxicological parameters in rabbits. Adult New Zealand rabbits were exposed to (PhSe)(2) (5-500 micromol kg(-1) , intraperitoneally) once a day for 5 days. Exposure to 500 micromol kg(-1) caused 85% mortality. Exposure to 50 micromol kg(-1) of (PhSe)(2) increased the glutathione levels in the hippocampus, kidney, heart, muscle and blood, whereas lipoperoxidation (TBARS) decreased in the cerebellum and kidney after exposure to 5 micromol kg(-1) . The activity of glutathione peroxidase increased in the heart and muscle of rabbits treated with 50 micromol kg(-1) of (PhSe)(2) and glutathione reductase activity was reduced in the cerebellum, cerebral cortex and kidney. Treatment with (PhSe)(2) reduced the activity of δ-aminolevulinate dehydratase in the hippocampus and increased this activity in the heart, but did not alter the activity of complexes I and II of the respiratory chain in the liver and brain. Hepatic and renal biochemical and histological parameters were not modified by (PhSe)(2) and apoptosis was not detected in these tissues; however, the hepatic cells tended to accumulate fat vacuoles. These results indicated that acute toxicology to (PhSe)(2) in rabbit is dependent on the dose, which should motivate further experiments on the therapeutic properties of this compound.

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Antioxidant effect of diphenyl diselenide against sodium nitroprusside (SNP) induced lipid peroxidation in human platelets and erythrocyte membranes: An in vitro evaluation

Cited by 43 publications

References 52 publications

Antioxidant effect of a novel class of telluroacetilene compounds: Studies in vitro and in vivo

Antioxidant effect of a novel class of telluroacetilene compounds: Studies in vitro and in vivo

Pharmacology and toxicology of diphenyl diselenide in several biological models

Acute exposure of rabbits to diphenyl diselenide: a toxicological evaluation

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