Antioxidant effect of gamma-tocopherol supplied by propofol preparations (Diprivan) during ischemia-reperfusion in experimental lung transplantation

Álvarez-Ayuso, Lourdes; Calero, Patricia; Granado, Fernando; Jorge, Eduardo; Herrero, Carmen; Torralba, Amalia; Millán, Isabel; Santos, Marino Barbero; Blanco, I.; Olmedilla, B.; Castillo‐Olivares, J. L.

doi:10.1111/j.1432-2277.2004.tb00407.x

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…At the same time, propofol acts as an antioxidant due to the gamma and alpha-tocopherol contained within its formula. [8,9] The reason for choosing sevoflurane as the inhalation anesthetic is that it reduces inflammation and oxidative stress and preserves the lung against ischemia and reperfusion injury. [10,11] The left side is often selected for endobronchial intubation in the LTx operations.…”

Section: Discussionmentioning

confidence: 99%

Anesthetic management in lung transplantation: Our single-center experience

Erkılınç¹,

Baysal²,

Gürcü³

2021

Turk Gogus Kalp Dama

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Background: In this study, we aimed to discuss our anesthesia management strategies, experiences, and outcomes in patients undergoing lung transplantation. Methods: Between December 2016 and December 2018, a total of 53 patients (43 males, 10 females; mean age: 46.1±13 years; range, 14 to 64 years) undergoing lung transplantation in our center were included. The anesthesia technique, patients" characteristics, and perioperative clinical and follow-up data were recorded. The stage of lung disease was assessed using the New York Heart Association functional classification. Results: Two patients underwent single lung transplantation, while 51 patients underwent double lung transplantation. Idiopathic pulmonary fibrosis was the most common indication in 41.5% of the patients. All patients had end-stage lung disease (Class IV) and 79% were oxygen-dependent. The extracorporeal membrane oxygenation support was given to 32 patients. Conclusion: The anesthetic management of lung transplantation is challenging, either due to the deterioration of the recipient"s physical performance and the complexity of the surgical techniques used. In general, a kind of mechanical support may be needed and extracorporeal membrane oxygenation is the first choice in the majority of patients. A close communication should be maintained between the surgeons, perfusion technicians, and anesthesiologists to ensure an optimal multidisciplinary approach and to achieve successful outcomes.

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Section: Discussionmentioning

confidence: 99%

Anesthetic management in lung transplantation: Our single-center experience

Erkılınç¹,

Baysal²,

Gürcü³

2021

Turk Gogus Kalp Dama

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“…35,36 The comparison with control patients, who received the vehicle only, ruled out the possibility that this increase was dependent on the tocopherol content of the propofol vehicle.…”

Section: Discussionmentioning

confidence: 99%

Anesthetic Propofol Enhances Plasma γ-Tocopherol Levels in Patients Undergoing Cardiac Surgery

Cavalca¹,

Colli

Veglia³

et al. 2008

Anesthesiology

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Background: Propofol (2,6-diisopropylphenol) is an anesthetic drug with antioxidant and antiinflammatory properties, documented both in vitro and in experimental models of ischemia-reperfusion injury and septic shock. These properties have been related to the similarity of its chemical structure to that of endogenous tocopherols, which are phenol-containing radical scavengers. This study evaluated the effects of propofol on ␣-and ␥-tocopherol (␣-and ␥-T) levels and on selected markers of oxidant-antioxidant and inflammatory status in patients undergoing cardiac surgery.Methods: Patients were randomly assigned for anesthesia with either propofol (propofol group, n ‫؍‬ 22) or sevoflurane (control group, n ‫؍‬ 21). Plasma levels of ␣-and ␥-T, individual antioxidant capacity, malondialdehyde, and interleukin 10 were measured before, during, and after anesthesia. In addition, levels of the proinflammatory prostaglandin E 2 as a marker of cyclooxygenase-2 activity and those of interleukin 10 were measured in whole blood cultured with bacterial lipopolysaccharide.Results: ␥-T levels increased significantly during surgery in propofol group (P < 0.0001 vs. control group). By contrast, ␣-T similarly decreased in both groups. Malondialdehyde and interleukin 10 increased markedly and individual antioxidant capacity decreased, without differences between groups. Prostaglandin E 2 levels measured 24 h after anesthesia induction were significantly lower in the propofol than in the control group. In vitro studies highlighted the different capacity of ␥-and ␣-T to impair prostaglandin E 2 synthesis by human monocytes challenged with bacterial lipopolysaccharide.Conclusions: The antiinflammatory properties of propofol that may be linked to its effect on ␥-T levels could be relevant in controlling the inflammatory response that accompanies tissue injury during reperfusion.

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Propofol post-conditioning after temporary clipping reverses oxidative stress in aneurysm surgery

Guo

Wang

et al. 2018

International Journal of Neuroscience

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Antioxidant effect of gamma-tocopherol supplied by propofol preparations (Diprivan) during ischemia-reperfusion in experimental lung transplantation

Abstract: Free radicals are involved in ischemia-reperfusion injury and inflammatory processes. The com-

Cited by 4 publications

References 26 publications

Anesthetic management in lung transplantation: Our single-center experience

Anesthetic management in lung transplantation: Our single-center experience

Anesthetic Propofol Enhances Plasma γ-Tocopherol Levels in Patients Undergoing Cardiac Surgery

Propofol post-conditioning after temporary clipping reverses oxidative stress in aneurysm surgery

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