Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy

Kahya, Volkan; Meriç, Ayşenur; Yazıcı, Mine; Yüksel, Meral; Mıdı, Ahmet; Gedikli, Orhan

doi:10.1017/s002221511000263x

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…Reduced thickness of lamina propria and vessel density was reported as well. [32] Both ellagitannins and ellagic acid are the main components of pomegranate extract, which have anti-inflammatory properties. They are metabolized by gut microbiota to yield urolithins.…”

Section: Chemical Compositionmentioning

confidence: 99%

Potent health effects of pomegranate

2014

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Accumulating data clearly claimed that Punica granatum L. (pomegranate) has several health benefits. Pomegranates can help prevent or treat various disease risk factors including high blood pressure, high cholesterol, oxidative stress, hyperglycemia, and inflammatory activities. It is demonstrated that certain components of pomegranate such as polyphenols have potential antioxidant, anti-inflammatory, and anticarcinogenic effects. The antioxidant potential of pomegranate juice is more than that of red wine and green tea, which is induced through ellagitannins and hydrosable tannins. Pomegranate juice can reduce macrophage oxidative stress, free radicals, and lipid peroxidation. Moreover, pomegranate fruit extract prevents cell growth and induces apoptosis, which can lead to its anticarcinogenic effects. In addition, promoter inhibition of some inflammatory markers and their production are blocked via ellagitannins. In this article, we highlight different studies on the therapeutic effects of pomegranate and their suggested mechanisms of actions.

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Section: Chemical Compositionmentioning

confidence: 99%

Potent health effects of pomegranate

2014

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“…There is an accumulating evidence that antioxidant resveratrol (Cerqueira et al, ) regulates several inflammations via catalytic antioxidant system (Chang and Crapo, ; Cuzzocrea et al, ; Kahya et al, ). Herein, KJD significantly inhibited the level of lipid peroxide MDA and also enhanced the level of superoxide dismutase in the liver tissues of FCA‐treated rats, implying that an antioxidant effect of KJD mediates antiinflammatory effect of KJD in FCA arthritis rat model.…”

Section: Discussionmentioning

confidence: 99%

Anti-rheumatoid Arthritis Effect of Kaejadan via Analgesic and Antiinflammatory Activityin vivoandin vitro

Yoon

Sohn

Kim³

et al. 2017

Phytother. Res.

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Although Kaejadan (KJD), an herbal cocktail of three medicinal plants (Lithospermum erythrorhizon, Cinnamomum loureirii, and Salvia miltiorrhiza), has been traditionally used for the treatment of rheumatoid arthritis, its scientific evidence is not fully understood. Hence, we investigated antiinflammatory and analgesic mechanism of KJD in vivo and in vitro. Kaejadan suppressed the number of writhing responses in mice treated by acetic acid and showed antinociceptive effect by tail-flick test. Kaejadan abrogated serotonin or carrageenan or Freund's complete adjuvant (FCA)-induced paw edema and also reduced the level of Evans Blue for vascular permeability. Furthermore, KJD effectively reduced the positive responses for C-reactive protein and rheumatoid arthritis test in FCA-treated rats. Of note, KJD inhibited the level of lipid peroxide malondialdehyde and enhanced the level of superoxide dismutase in the hepatic tissues of FCA-treated rats. Additionally, KJD abrogated the levels of IL-1β and IL-6 in lipopolysaccharide and IFN-γ-exposed RAW 264.7 cells. Also, KJD reduced the expression of cyclooxygenase 2 or inducible nitric oxide synthase at protein and mRNA levels in IFN-γ and lipopolysaccharide-exposed RAW 264.7 cells. Overall, our findings demonstrate that KJD exerts antiinflammatory and analgesic effects via enhancement of antioxidant activity and inhibition of proinflammatory cytokines. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Kahya et al [35] evaluated the density of inflammatory cells in the middle ear in myringotomized rats to which pomegranate was applied; the study demonstrated that the density of inflammatory cells and MS were reduced compared to what happened with the control and saline groups. Similarly, Dogan et al [28] showed that the severity of inflammation and MS lessened in the treatment group after the administration of L-NAME.…”

Section: Discussionmentioning

confidence: 99%

“…Angiogenesis was used as a parameter in some studies of myringosclerosis; some authors associated angiogenesis with myringosclerosis, and still, other authors reported that they had found the relationship [25,35] . In our study, the severity of angiogenesis did not differ significantly in any group.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

Tatar¹,

Yörük²,

Ünal³

et al. 2015

Int Adv Otol

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OBJECTIVE: Alpha-lipoic acid (ALA) is an anti-inflammatory and antioxidant agent. In this study, the effects of ALA on the development of myringosclerosis in myringotomized rats were investigated. MATERIALS and METHODS:The rats were studied in five groups: each group included 6 rats (for a total of 30 rats). After a myringotomy was performed, the groups were administered a 25-mg/kg/day and 50-mg/kg/day dose of ALA for 15 days. The eardrums of the rats were examined histopathologically. We made the histopathological assessment from 0 to 3 on a 4-point scale by scoring the degree of the histopathological changes. In addition, superoxide dismutase, malondialdehyde, and glutathione peroxidase levels were measured in blood samples taken from the rats. RESULTS:In histopathological examinations, a high dose (50 mg/kg/day) of the ALA-applied group had histopathological results similar to those of the healthy group. In this group, we detected minimal collagen deposition, slight thickness in the lamina propria, and minimal epithelial disruption. In biochemical examinations, the maximum values of superoxide dismutase and glutathione peroxidase were observed in the group that received 50 mg/kg/day of ALA. CONCLUSION:In this study, the effect of ALA on myringosclerosis development was observed when a dose of 50 mg/kg/day was administered, and a recovery that showed a nearly intact tympanic membrane occurred at the end of 15 days of use. If an antioxidant were to be added to the treatment protocol of tympanic membrane defects, ALA may be a good candidate.

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Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy

Abstract: Our results indicate that oral pomegranate extract decreases reactive oxygen species concentration and acute inflammation in the tympanic membrane after myringotomy.

Cited by 9 publications

References 23 publications

Potent health effects of pomegranate

Potent health effects of pomegranate

Anti-rheumatoid Arthritis Effect of Kaejadan via Analgesic and Antiinflammatory Activityin vivoandin vitro

The Effect of Alpha-Lipoic Acid on Myringosclerosis in a Rat Model

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