Antioxidant Effect on Urinary Excretion of Malondialdehyde in Non-Athletes During Aerobic Training

Hadley, M.; Visser, Marleen; Steen, Travis Vander

doi:10.1024/0300-9831.79.1.5

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Previous research by Hadley et al28 found an increase in urinary MDA excretion following exercise in the unsupplemented group and a decrease in urinary MDA following exercise in the supplemented (vitamins C and E) group. Similarly, we found no significant difference in serum MDA between quercetin and placebo before training.…”

Section: Discussionmentioning

confidence: 75%

Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners

Scholten¹,

Сергеев²

2013

OAJSM

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PurposeTo evaluate the effects of chronic quercetin supplementation on endurance performance and antioxidant status in long distance runners. We hypothesized that an improved antioxidant status can be associated with enhanced performance.MethodsDuring 6 weeks of supplementation utilizing a double blind, randomized design, young male subjects received quercetin (1000 mg/day) or placebo while maintaining their current training schedules.ResultsFollowing the end of the supplementation period, there was a significant time × supplement interaction for serum malondialdehyde (MDA), an indicator of lipid peroxidation. There were no significant pre- to post-supplement changes in parameter values employed for measuring total antioxidant capacity, superoxide dismutase activity, and protein oxidation (protein carbonyl) in serum. There were also no significant pre- to post-supplement differences in VO2peak, running economy, heart rate, and rating of perceived exertion (RPE) during the 10 km time trial.ConclusionThe findings obtained indicate that there is a relationship between quercetin supplementation and the statistically significant decreasing trend in MDA levels following 6 weeks of supplementation and training. This evidence suggests that quercetin can reduce oxidative stress (lipid peroxidation). However, performance improvements were not significant (as measured by VO2peak, running economy, heart rate, and RPE).

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Section: Discussionmentioning

confidence: 75%

Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners

Scholten¹,

Сергеев²

2013

OAJSM

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“…In another study urine samples obtained from rats challenged with oxidative stress by treatement with iron nitrilotriacetate or carbon tetrachloride or vitamin E deficiency were found to have MDA present on proteins, nucleic acid bases, and phospholipids as measured by HPLC (Draper et al, 2000) A similar excretion pattern, albeit in much smaller amounts, was observed in urine samples obtained from humans (Draper et al, 2000). Additionally, it has been shown that MDA levels in human urine can be modulated by diet, physical exercise, and smoking (Hadley, Visser, & Vander Steen, 2009; Mellor, Hamer, Smyth, Atkin, & Courts, 2010).…”

Section: Generation Of Mda Epitopesmentioning

confidence: 99%

Malondialdehyde Epitopes as Targets of Immunity and the Implications for Atherosclerosis

Papac-Miličević

Busch

Binder

2016

Advances in Immunology

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Accumulating evidence suggests that oxidation-specific epitopes (OSEs) constitute a novel class of damage-associated molecular patterns (DAMPs) generated during high oxidative stress but also in the physiological process of apoptosis. To deal with the potentially harmful consequences of such epitopes, the immune system has developed several mechanisms to protect from OSEs and to orchestrate their clearance, including IgM natural antibodies and both cellular and membranebound receptors. Here, we focus on malondialdehyde (MDA) epitopes as prominent examples of OSEs that trigger both innate and adaptive immune responses. First, we review the mechanism of MDA generation, the different types of adducts on various biomolecules and provide relevant examples for physiological carriers of MDA such as apoptotic cells, microvesicles (MV) or oxidized low-density lipoproteins (LDL). Based on recent insights, we argue that MDA epitopes contribute to the maintenance of homeostatic functions by acting as markers of elevated oxidative stress and tissue damage. We discuss multiple lines of evidence that MDA epitopes are proinflammatory and thus important targets of innate and adaptive immune responses. Finally, we illustrate the relevance of MDA epitopes in human pathologies by describing their capacity to drive inflammatory processes in atherosclerosis and highlighting protective mechanisms of immunity that could be exploited for therapeutic purposes. Keywords inflammation; atherosclerosis; oxidative stress; immunity; malondialdehyde; oxidized low density lipoprotein; oxidation-specific epitopes; damage-associated molecular pattern OverviewCellular stress, senescence, and cell death are tightly associated with oxidative stress. A major consequence of increased oxidative stress is the peroxidation of membrane lipids resulting in the generation of various oxidation specific epitopes (OSEs). OSEs and the immune responses targeting them have been implicated in many acute and chronic inflammatory diseases, most prominently atherosclerosis. Studies of the biological activities of oxidized LDL (OxLDL), which is a key pathogenic driver of atherosclerosis, have helped identify OSE as a novel class of damage-associated molecular patterns (DAMPs). In this

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“…There are reports of impairment of physical performance due to long-term vitamin deficiency, in support of the importance of vitamin supplementation in physical activity [2]. Athletes are often recommended to take vitamin/mineral supplements for better performance [3].…”

Section: Introductionmentioning

confidence: 99%

Elements in Sera of Elite Taekwondo Athletes: Effects of Vitamin E Supplementation

Patlar

Boyali

Baltacı

et al. 2010

Biol Trace Elem Res

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Many researchers have emphasized the relation between nutrition and development and sustaining performance. Two methods are commonly employed to identify the interaction between physical activity and nutrition. The first consists of administering food with a variety of contents to people engaged in physical activity and observing their performance responses, and the other is concerned with determining the effects of physical activity on nutrition. Therefore, it can be said that there has been a growing interest in the explorations into the relation between exercise and vitamins, minerals, and elements. The present study reports the effects of 6 weeks administration of 300 mg/day vitamin E on the distribution of serum elements in elite taekwondo athletes. Seven male athletes, mean ages 22.1 ± 0.5 years weighing on average 66.4 ± 2.4 kg were included in the study. The athletes had been practicing taekwondo for 10-12 years. Resting blood samples were collected in duplicate before and after supplementation for determination of serum levels of cobalt, boron, cadmium, chromium, nickel, manganese, sulfur, copper, iron, zinc, phosphorus, sodium, potassium, and calcium. Supplementation resulted in significant increases of all elements relative to values before supplementation (p < 0.001), with the exception of boron and sulfur, which remained without change. The results of the present study demonstrate that vitamin E supplementation crucially influences the element and mineral metabolism in elite athletes.

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Antioxidant Effect on Urinary Excretion of Malondialdehyde in Non-Athletes During Aerobic Training

Cited by 4 publications

References 29 publications

Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners

Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners

Malondialdehyde Epitopes as Targets of Immunity and the Implications for Atherosclerosis

Elements in Sera of Elite Taekwondo Athletes: Effects of Vitamin E Supplementation

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