Antioxidant Effects of Calcium Antagonists in Rat Brain Homogenates.

Yao, Kozo; Ina, Y.; Nagashima, Ken; Ohmori, Kenji; Ohno, Tetsuji

doi:10.1248/bpb.23.766

Cited by 42 publications

(30 citation statements)

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“…Moreover, vascular smooth muscles contracted by potassium were reported to be inhibited by nilvadipine (13). It antagonizes both L-and T-type Ca 2+ channels (14) and exerts an antioxidant effect (15) that is reported to be greater than the effects of nimodipine, nicardipine, and amlodipine (16). It has also been reported that nilvadipine (but not amlodipine) increased striatal dopamine and DOPAC contents and protected against motor deficits in mice (17).…”

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confidence: 99%

Effect of Nilvadipine on the Cerebral Ischemia-Induced Impairment of Spatial Memory and Hippocampal Apoptosis in Rats

et al. 2003

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Abstract. We investigated the effects of nilvadipine and amlodipine on the cerebral ischemiainduced impairment of spatial memory in 8-arm radial maze performance and hippocampal CA1 apoptosis in rats. Single cerebral ischemia impaired memory without inducing apoptosis. In these rats, neither nilvadipine nor amlodipine at 3.2 mg / kg, i.p. improved the impaired memory. On the other hand, repeated cerebral ischemia (10 min ischemia ´2, 1 h interval) impaired spatial memory and induced hippocampal apoptosis 7 days after the final occlusion / reperfusion. Moreover, repeated ischemia increased the apoptotic cell number, an effect observed after 3 days and peaked after 7 days. However, mRNA expression of the apoptosis-related early oncogene bax and CPP 32 (caspase-3) was observed after 24 h. In these rats, nilvadipine, but not amlodipine, significantly improved memory, concomitantly decreased hippocampal apoptosis, and suppressed both bax and CPP 32 expression. These results suggest that nilvadipine improved the memory impairment in repeated ischemia by reducing bax and CPP 32 expression and suppressing the induction of apoptosis in the hippocampus. Nilvadipine may have a neuroprotective effect and could be a useful pharmacotherapeutic agent for cerebrovascular dementia.

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Section: +mentioning

confidence: 99%

Effect of Nilvadipine on the Cerebral Ischemia-Induced Impairment of Spatial Memory and Hippocampal Apoptosis in Rats

et al. 2003

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“…Numerous reports have referred to the antioxidant effect of benidipine, 30 which is more potent than that of diltiazem or verapamil. 31 Decreased free radicals contribute to the prolongation of NO. This antioxidant effect of benidipine may contribute to the improvement of endothelial function.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Calcium-Channel Blockers on Vascular Endothelial Function in Patients With Coronary Spastic Angina

Miwa

Masai

Shimizu

2009

Circ J

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“…36) Thus, anti-oxidative property based on chemical structure of benidipine, 10,11) one of the pleiotrophic actions, may be involved in the normalization of dysautoregulation of cerebral circulation.…”

Section: Discussionmentioning

confidence: 99%

“…5) Moreover, benidipine has pleiotrophic pharmacological actions, such as up-regulation of endothelial NO synthase [6][7][8][9] and anti-oxidative property based on chemical structure, 10,11) distinct from VDCC blockade. These favorable pleiotrophic actions can offer additional benefits in clinical usage of benidipine.…”

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confidence: 99%

Effects of Benidipine, a Long-Lasting Dihydropyridine-Ca2+ Channel Blocker, on Cerebral Blood Flow Autoregulation in Spontaneously Hypertensive Rats

Ikeda

Yao

Matsubara

2006

Biological & Pharmaceutical Bulletin

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Chronic hypertension shifts cerebral blood flow (CBF) autoregulation towards higher blood pressure. We examined whether or not benidipine, a long-lasting dihydropyridine calcium channel blocker (CCB), improves the CBF autoregulation in spontaneously hypertensive rats (SHRs). CBF was analyzed by laser-Doppler flowmetry during stepwise hypotension by controlled bleeding. The lower limit of CBF autoregulation was calculated as the mean arterial blood pressure at which CBF decreased by 10% of the baseline. Mean arterial blood pressure and cerebral vascular resistance in SHRs were higher than those in normotensive Wistar rats. Oral administration of benidipine (3 mg/kg) for 8 d lowered the mean arterial blood pressure and cerebral vascular resistance, which were equivalent to the effects of amlodipine (3 mg/kg), another CCB, or candesartan (1 mg/kg), an Angiotensin II type-1 receptor blocker. The lower limit of CBF autoregulation in SHRs (142؎4 mmHg) was significantly shifted to a higher-pressure level compared with Wistar rats (59؎2 mmHg). The lower limit of CBF autoregulation was significantly lower in the benidipine-treated group (91؎4 mmHg) than that in the control SHRs, and similar to that of the amlodipine group (97؎6 mmHg). Benidipine reduced the lower limit of CBF autoregulation more effectively than candesartan (109؎4 mmHg). In conclusion, benidipine shifted the limit of CBF autoregulation towards lower blood pressure in SHRs under hypotensive conditions by hemorrhage. These results suggest that benidipine may be useful for the treatment of hypertensive patients with the elderly or cerebrovascular disorders, in whom autoregulation of CBF is impaired.

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Antioxidant Effects of Calcium Antagonists in Rat Brain Homogenates.

Cited by 42 publications

References 0 publications

Effect of Nilvadipine on the Cerebral Ischemia-Induced Impairment of Spatial Memory and Hippocampal Apoptosis in Rats

Effect of Nilvadipine on the Cerebral Ischemia-Induced Impairment of Spatial Memory and Hippocampal Apoptosis in Rats

Differential Effects of Calcium-Channel Blockers on Vascular Endothelial Function in Patients With Coronary Spastic Angina

Effects of Benidipine, a Long-Lasting Dihydropyridine-Ca2+ Channel Blocker, on Cerebral Blood Flow Autoregulation in Spontaneously Hypertensive Rats

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