Antioxidant effects of proanthocyanidin‐rich natural extracts from grape seed and cupuassu on gastrointestinal mucosa

Pinent, Montserrat; Castell-Auví, Anna; Genovese, Maria Inês; Serrano, Joan; Casanova, Angela Oliveira; Blay, Mayte; Ardévol, Anna

doi:10.1002/jsfa.7079

Cited by 42 publications

(28 citation statements)

References 28 publications

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“…Catechin and proanthocyanidin were reported to possess a strong effect on ROS to reduce peroxidation . In this study, the levels of total polyphenols in the liver did not increase after 7 days of pretreatment with the Ao diet.…”

Section: Discussionmentioning

confidence: 42%

Preventive Effect of Antioxidative Nutrient‐Rich Enteral Diet Against Liver Ischemia and Reperfusion Injury

Miyauchi

Uchida

Kadono

et al. 2018

J Parenter Enteral Nutr

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Section: Discussionmentioning

confidence: 42%

Preventive Effect of Antioxidative Nutrient‐Rich Enteral Diet Against Liver Ischemia and Reperfusion Injury

Miyauchi

Uchida

Kadono

et al. 2018

J Parenter Enteral Nutr

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“…Bioactive compounds have shown promising anti‐inflammatory, antimicrobial and other beneficial health effects due to their antioxidant role, and seeds are one of the main food sources of such compounds . As previously mentioned, all the seven trial extracts presented a high content of total phenolic compounds (Table ).…”

Section: Resultsmentioning

confidence: 82%

“…Grape seeds comprise 38% to 52% of the grape pomace, on a dry mater basis, being characterized as a complex matrix composed of approximately 40% fiber, 16% oil, 11% protein, and other components including phenolic compounds, sugars and minerals . According to the scientific literature, grape seeds are a rich source of natural antioxidants and their extracts have different health benefits …”

Section: Introductionmentioning

confidence: 99%

Grape seed pomace as a valuable source of antioxidant fibers

et al. 2019

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BACKGROUND Grape seed pomace is a valuable by‐product from winery/oil extraction industries and a potential source of bioactive compounds. Hot water extraction is the most widely used technology for polysaccharide recovery from plant and seed sources. To obtain an antioxidant fiber‐rich extract (AFE) from defatted grape seed pomace, seed:water ratio (1:10–1:20) and extraction temperature (70–90 °C) effects on extraction yield, total sugars, total phenolic compounds and condensed tannins were investigated. RESULTS The best extraction results were achieved at the highest seed:water ratio and temperature. At these conditions, the extraction yield and total sugar content of the freeze‐dried AFE were 100.1 g kg−1 and 725.3 g kg−1, respectively. The AFE presented high total phenolic content (16.2 g GAE kg−1), condensed tannins (515.1 mg CAT kg−1), soluble (219.1 g kg−1) and insoluble fibers (132.4 g kg−1), besides protein (171.1 g kg−1) and ash (152.6 g kg−1). The antioxidant capacity of the AFE was 382.7, 823.7 and 1439.4 μmol Trolox g−1 for DPPH, ABTS and ORAC methods. CONCLUSION The AFE was shown to be not only an interesting source of fiber with antioxidant capacity, which could become a potential foodstuff, but also an ecofriendly and sustainable alternative to use grape seed pomace. © 2019 Society of Chemical Industry

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“…Health beneficial properties have been proposed for cupuassu, being the antioxidant capacity one of the most studied (Santos et al, 2010;Pinent et al, 2015). Antidiabetic potential was also evaluated and cupuassu fruit showed the most potent inhibition of α-amylase activity among sixteen Brazilian native fruits and six commercial frozen pulps .…”

Section: -O-β-d-glucuronides and The Corresponding 3"-sulfates Of Ismentioning

confidence: 99%

“…Ex Spreng) Shum. is a native fruit from the Amazon region phylogenetically close to cocoa, which contains flavanols and other phenolic compounds that are known by their antioxidant capacity and by their potent inhibition of α-amylase activity in vitro Pinent et al, 2015). Moreover, the effects of chronic daily intake of cupuassu liquor upon metabolic alterations associated to type1 diabetes or to a high fat diet were recently evaluated, showing improvement of plasma lipid profile, antioxidant defenses and glucose tolerance Rogero, & Genovese, 2013;.…”

Section: Introductionmentioning

confidence: 99%

Efeito dos compostos fenólicos do camu-camu e do cupuaçu no desenvolvimento da obesidade e diabetes mellitus tipo 2

Barros¹

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Efeito dos compostos fenólicos do camu-camu e do cupuaçu no desenvolvimento da obesidade e diabetes mellitus tipo 2Ao meu marido Edgard, por seu amor, sua compressão e seu apoio em todas as fases deste trabalho. Você foi a pessoa que mais acreditou desde o começo, e seu incentivo foi fundamental! Obrigada por mudar sua vida para poder realizar um sonho meu! Aos meus pais Marina e Luiz Carlos e à minha irmã e amiga Marta pelo carinho, apoio incondicional e por sempre demonstrarem orgulho desta jornada.À minha querida prima e amiga Camila e ao meu irmão Roberto, mesmo que distantes fisicamente, por me tranquilizarem nos momentos difíceis e por me inspiraram como pesquisadores.Aos meus colegas de laboratório e amigos queridos: Alice, Carlos, Ciça, Daniel, Diully, Flavinha, Gabi Cunha, Gabi Pedrosa, Helô, Luana, Marcela, Marcio, Renata e Taty pela companhia, amizade e troca de conhecimentos, obrigada a todos vocês! À Fernanda Santana, por sua amizade e ajuda com as análises de lipídeos.À Beatriz Mendonça, "minha filhinha" querida, pela participação na parte experimental, sempre com comprometimento e alegria.À Joana, por nos ajudar a manter o "antigo" laboratório em ordem. The incidence of obesity and type 2 diabetes reached epidemic proportions in recent years, arriving to billions of people around the world. The discovery of innovative ways that can reduce the metabolic abnormalities associated with these diseases is essential to minimize its impact on the population's quality of life and the economy of the countries. Many studies have demonstrated that food bioactive compounds have beneficial health effects. Camu-camu and cupuassu are native fruits of the Amazon region with unexplored agroeconomic potential, which contain a large number of phytochemical compounds that can act on body metabolism.Thus, the objective of this study was verify the effects of phenolic compounds of camu-camu and cupuassu extracts on the development of obesity and type 2 diabetes in vivo and in vitro, and identfy the possible metabolites involved in these effects. The phenolic compound-rich extracts were obtained from commercial frozen fruit pulps by solid phase extraction, characterized by high-performance liquid chromatography (HPLC/DAD) and evaluated for inhibition of digestive enzymes activities in vitro. Then, the extracts were tested at two different doses (2.25 and 4.5 mg catechin equivalents/kg body weight for cupuassu; 7 and 14 mg of gallic acid equivalents/kg body weight for camu camu) in an animal model (C57BL/6J mice) of obesity and insulin resistance induced by high fat high sucrose diet. The effects of extract supplementation on glucose and lipid homeostasis were assessed by serum analysis, insulin and glucose tolerance tests in mice, and contents of fat in liver and fecal samples.Camu camu extract presented flavonols, ellagic acid and ellagitannins in its composition.Supplementation with camu camu phenolic extract reduced weight gain and decreased glucose and insulin intolerance independent of the dose administered. However...

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Antioxidant effects of proanthocyanidin‐rich natural extracts from grape seed and cupuassu on gastrointestinal mucosa

Abstract: Natural proanthocyanidin-rich extracts have an antioxidant effect in the GI tract, acting on absorptive cells and enterohormone-secreting cells, although the effects depend on the dose and period of treatment. © 2015 Society of Chemical Industry.

Cited by 42 publications

References 28 publications

Preventive Effect of Antioxidative Nutrient‐Rich Enteral Diet Against Liver Ischemia and Reperfusion Injury

Preventive Effect of Antioxidative Nutrient‐Rich Enteral Diet Against Liver Ischemia and Reperfusion Injury

Grape seed pomace as a valuable source of antioxidant fibers

Efeito dos compostos fenólicos do camu-camu e do cupuaçu no desenvolvimento da obesidade e diabetes mellitus tipo 2

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