Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice

Noh, Jung‐Ran; Gang, Gil-Tae; Kim, Yong‐Hoon; Yang, Keum Jin; Hwang, Jung-Hwan; Lee, Hyun-Sun; Oh, Wook; Song, Kyung‐Sik; Lee, Chul‐Ho

doi:10.1016/j.fct.2010.08.018

Cited by 66 publications

(53 citation statements)

References 29 publications

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“…The antioxidant compounds such as scoparone and scopoletin isolated from CCP are known to possess anti-oxidant properties and antiinflammatory activities [20][21][22]. CCP was reported to suppress the liver cytotoxicity induced by chronic ethanol administration due to its potent antioxidant effects [17,18]. Reports also revealed that CCP possess neuroprotective activity and anti-amnesic activities by attenuating the ROS and oxidative stress in neuronal cells [8].…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of lipopolysaccharide-induced neuroinflammatory events in Bv-2 microglia by chestnut peel extract

Kang¹

2014

Trop. J. Pharm Res

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Purpose: To evaluate the protective effects of chestnut (Castenea cranata Siebold & Zucc., Fagaceae) peel extract on stimulated BV-2 microglial cells as well as its anti-oxidant properties. Methods: The ethyl acetate fraction of C.cranata peel (CCP) extract was used in the study to evaluate the anti-neuroinflammatory effects in BV-2 microglial cells. Cell viability was performed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. Lipopolysaccharide (LPS) is used to activate BV-2 microglia. Nitric oxide (NO) levels were measured using Griess assay. Inducible NO synthase (iNOS) expressional levels were measured by Western blot analysis. Tumor necrosis factoralpha (TNF-α) production was evaluated by enzyme-linked immunosorbent assay (ELISA

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Section: Discussionmentioning

confidence: 99%

“…It was well known that DPPH radical assay as one of the widely used methods for evaluating the free radical scavenging activities of several antioxidants [9]. Earlier reports revealed that CCP possessed strong antioxidant compounds [17,18]. It has been demonstrated that chestnut fruits contain several phenolic compounds [19].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of lipopolysaccharide-induced neuroinflammatory events in Bv-2 microglia by chestnut peel extract

Kang¹

2014

Trop. J. Pharm Res

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“…Particularly, its leaves have been applied in treatment of whooping cough and lacquer poisoning in folk medicine [2]. Furthermore, the inner skins of chestnuts have long been used in East Asia, especially in Korea, as an ingredient in cosmetics [5]. …”

Section: Introductionmentioning

confidence: 99%

Phenolic Compositions and Antioxidant Properties in Bark, Flower, Inner Skin, Kernel and Leaf Extracts of Castanea crenata Sieb. et Zucc

et al. 2017

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In this study, different plant parts (barks, flowers, inner skins, kernels and leaves) of Castanea crenata (Japanese chestnut) were analyzed for total phenolic, flavonoid, and tannin contents. Antioxidant properties were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), reducing power, and β-carotene bleaching methods. The highest total phenolic and tannin contents were found in the inner skins (1034 ± 7.21 mg gallic acid equivalent/g extract and 253.89 ± 5.59 mg catechin equivalent/g extract, respectively). The maximum total flavonoid content was observed in the flowers (147.41 ± 1.61 mg rutin equivalent/g extract). The inner skins showed the strongest antioxidant activities in all evaluated assays. Thirteen phenolic acids and eight flavonoids were detected and quantified for the first time. Major phenolic acids were gallic, ellagic, sinapic, and p-coumaric acids, while the principal flavonoids were myricetin and isoquercitrin. The inner skin extract was further fractionated by column chromatography to yield four fractions, of which fraction F3 exhibited the most remarkable DPPH scavenging capacity. These results suggest that C. crenata provides promising antioxidant capacities, and is a potential natural preservative agent in food and pharmaceutical industries.

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“…In pre-incubation experiments, in which cells are exposed to the toxic agent (tBHP) in fresh medium after removal of test compounds, it is expected that reduction of tBHP-induced damage will be due to cellular mediated effects, such as increased enzymatic (e.g. SOD) (Huang et al, 2006;Noh et al, 2010) and non-enzymatic cellular antioxidants, as glutathione (Alía et al, 2006;Izigov et al, 2011). Note that the extract and fraction, by themselves, had no effect on superoxide radical anion production (Fig.…”

Section: Measurement Of Superoxide Radical Scavenging Capacity Of Cormentioning

confidence: 95%

Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells

Dias¹,

Liu²,

Jones³

et al. 2012

Journal of Ethnopharmacology

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Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice

Cited by 66 publications

References 29 publications

Inhibition of lipopolysaccharide-induced neuroinflammatory events in Bv-2 microglia by chestnut peel extract

Inhibition of lipopolysaccharide-induced neuroinflammatory events in Bv-2 microglia by chestnut peel extract

Phenolic Compositions and Antioxidant Properties in Bark, Flower, Inner Skin, Kernel and Leaf Extracts of Castanea crenata Sieb. et Zucc

Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells

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