Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling

Kagan, Valerian E.; Serbinova, E. A.; Packer, Lester

doi:10.1016/0006-291x(90)91971-t

Cited by 338 publications

(147 citation statements)

References 10 publications

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“…Cholesterol ester hydroperoxides were the major species formed (mean -± SD, 2.9 +_ 1.8 btM for 3 different plasma samples after 6 h exposure to NO]), whereas levels of phospholipid hydroperoxides in the saree experiments were only 0.03-0.18/IM. There was also loss of ubiquinol, another lipid-soluble antioxidant [30,31], in NO.X-exposed plasma. For example, whereas 6 h of exposure to NO.~ depleted ~Xotocopherol in haman plasma from 40.6 + 5.7 /.tM (mean + SD, 5 different plasma samples) to 20.5 +_ 4.0/.tM, ubiquinol was completely lost (0.95 + 0.05 buM to zero; n = 3).…”

Section: Resultsmentioning

confidence: 96%

Interaction of nitrogen dioxide with human plasma Antioxidant depletion and oxidative damage

et al. 1992

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Nitrogen dioxide (NO'.,) is often present in inhaled air and ,nay be generated in viva from tfitrie oxide. Exposure of human blood plasma to NO~ caused rapid los~es of as¢orbic acid, uric acid and protein thiol groups, as well as lipid peroxidation and depletions ofcz-to¢opherol, bilirabia and ubiqninol-10. No increase in protein carbonyls was detected. $ttpplementation of plasma with ascorbate decreased the rules of lipid pero~idation, 0:-tocopherol del~letion and 1o~5 of uric acid. Uric acid supplementation decreased rat¢~ of lipid peroxidation but not the loss ofcx-toeopherol, We conclude Ihat a~corbic acid, protein -SH groups, uric a~:id and ~z-tocophcrol may be important agents protecting against NO~ in viva. If these antioxidants are depleted, peroxidation of lipids occurs and might contribute to the toxicity of NO'.,.

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Section: Resultsmentioning

confidence: 96%

Interaction of nitrogen dioxide with human plasma Antioxidant depletion and oxidative damage

et al. 1992

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“…Alpha-lipoic acid inclusion in vivo increases the level of ubiquinol, which is the substance known to recycle vit. E under oxidative stress circumstances (Götz et al, 1994;Kagan et al, 1990). A study showed that 500 mg vit.…”

Section: Discussionmentioning

confidence: 99%

Growth performance, intestinal morphology, and meat quality in relation to alpha-lipoic acid associated with vitamin C and E in broiler chickens under tropical conditions

Yoo

Koo

et al. 2016

R. Bras. Zootec.

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-This study was conducted to examine the effect of alpha-lipoic acid with vitamin C and E on growth performance, intestinal morphology, and meat quality in broiler chickens under tropical conditions. A total of 288 one-day-old male ROSS 308 chicks (40±0.1 g) were used in a completely randomized design and allotted to one of six dietary treatments to form sixe replicates per treatment (eight birds per cage). The six dietary treatments were: a corn-soybean meal-based diet (NC; no antimicrobial compounds added) with 8 ppm alpha-lipoic acid (ALA); 150 ppm vitamin C and 75 ppm vitamin E (E-75); E-75 plus ALA (E-75-ALA); 150 ppm vitamin C and 50 ppm vitamin E (E-50) plus ALA (E-50-ALA); and 150 ppm vitamin C and 25 ppm vitamin E (E-25) plus ALA (E-25-ALA). All dietary treatments were continuously provided in liquid form, dissolved in water. Birds were housed in a battery cage (n = 36), and were offered dietary treatments on an ad libitum basis. The ambient temperature was maintained at 32±1 ºC for the first three weeks and reduced gradually to 28 ºC by the end of the experiment (day 35) to induce moderate tropical condition. One bird per pen (n = 6), and another bird per pen (n = 6) were euthanized via cervical dislocation to obtain terminal ileum to measure villus height and crypt depth at day 21, and to harvest breast meat and drumsticks to evaluate meat quality traits at day 35, respectively. Dietary treatment E-75-ALA improved body weight and average daily gain compared with birds fed other dietary treatments from day 1 to day 35. Birds fed dietary treatment E-75-ALA and E-50-ALA had higher villus height than those fed the other dietary treatments at day 21. Dietary treatments E-75-ALA and E-50-ALA reduced thiobarbituric acid reactive substance (TBARS) in drumsticks compared with other dietary treatments, but only treatment E-75-ALA decreased TBARS in breast meat at day 35. Liquid form of antioxidant compounds such as E-75-ALA can improve growth performance, histology of terminal ileum, and meat quality traits in broiler chickens under moderate tropical condition for 35 days.

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“…With tocopherol, ubiquinol acts as an antioxidant to stem lipid peroxidation in the inner mitochondrial membrane (Kagan et al 1990;ForsmarkAndree et al 1995;Lass & Sohal 1998;James et al 2004). Ubiquinol can rescue tocopheryl radicals produced by the reactions with lipid or oxygen radicals by a direct reduction back to tocopherol (Arroyo et al 2000).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Nourishing and health benefits of coenzyme Q<sub>10</sub>

Borekova¹,

Hojerová²,

Koprda³

et al. 2008

Czech J. Food Sci.

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Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling

Cited by 338 publications

References 10 publications

Interaction of nitrogen dioxide with human plasma Antioxidant depletion and oxidative damage

Interaction of nitrogen dioxide with human plasma Antioxidant depletion and oxidative damage

Growth performance, intestinal morphology, and meat quality in relation to alpha-lipoic acid associated with vitamin C and E in broiler chickens under tropical conditions

Nourishing and health benefits of coenzyme Q<sub>10</sub>

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